The osmotic laxative magnesium sulphate activates the ileal brake

Abstract

Background: Alterations in gastrointestinal motility and hormone secretion, especially activation of the ileal brake, have been documented in malabsorption. Aim: To investigate whether artificially‐induced accelerated small intestinal transit activates the ileal brake mechanism. Methods: Eight healthy volunteers (four female, four male; age 21 ± 3 years) participated in four experiments: (a) meal with either oral magnesium sulphate (MgSO4) or placebo; and (b) fasting with either oral MgSO4 or placebo. Antroduodenal motility was recorded by perfusion manometry. Duodenocaecal transit time was determined by the lactulose H2 breath test. Gall‐bladder volume was measured by ultrasound at regular intervals, and blood samples were drawn for determination of cholecystokinin and peptide YY (RIA). Twenty‐four hour faecal weight and fat excretion were determined. Results: MgS04 significantly accelerated duodenocaecal transit time and increased faecal fat and weight in all subjects. MgSO4 significantly delayed the reoccurrence of phase III and affected antroduodenal motility during fasting but not after meal ingestion. Postprandial gall‐bladder relaxation and postprandial peptide YY release were significantly increased during the MgSO4 experiment compared to placebo. Conclusions: The osmotic laxative MgS04 accelerates intestinal transit both in the fasting and fed state. MgS04 activates the ileal brake mechanism only in the fed state, with peptide YY release and inhibition of gall‐bladder emptying.

Development and physiology of gastric dilation air sacculitis in Chinook salmon, Oncorhynchus tshawytscha (Walbaum)

“…Once this chyme reaches the proximal intestine, an intestinal brake is activated via nutritive chemoreception (Jobling 1987;Olsson & Holmgren 2001). This has been demonstrated in mammals (Vu, Nouens, Biemond, Lamers & Masclee 2000) and fish (Olsson & Holmgren 2001) and it is thought that the intestinal brake in fish parallels the ileal brake in mammals (Olsson, Aldman, Larsson & Holmgren 1999). The data presented in the current study suggest an overactive intestinal brake mechanism may be at work in the pathological development of GDAS.…”

Antacid attenuates the laxative action of magnesia in cancer patients receiving opioid analgesic

“…[22] They also showed that the fluid retention induced in the intestinal lumen as well as the diarrhoea induced by magnesium sulfate are inhibited by L-NAME. [22] On the other hand, Vu et al [23] showed in healthy volunteers that magnesium sulfate given in combination with a fatty meal causes diarrhoea with a concomitant increase in postprandial plasma peptide YY and cholecystokinin.…”

Functional Gastrointestinal Disorders: Future Use Medical Mineral Water

“…Известно, что соли магния, например сульфат магния, оказывают влияние на осмотические процессы, ускоряю-щие время прохождения содержимого через кишечник и приводящие к улучшению консистенции стула [16,17].…”