“…We identified 61 articles from our search of the databases: 30 from PubMed [1, 11, 15–42], six from Cochrane [43–48], and 25 from EMBASE [4–7, 9, 11, 31, 37, 49–65]. Three of these studies were found in both the PubMed and EMBASE databases [11, 31, 37]. Twenty-two studies [21, 23, 24, 31–35, 38, 39, 41, 46, 51, 52, 54–56, 58–61, 64] were excluded because they reported closed tibia fractures exclusively or in addition to open tibia fractures, and not enough data was supplied to analyze the open tibia fractures separately.…”