The orthomolecular treatment of cancer II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer

Cameron, Ewan; Campbell, Allan

doi:10.1016/0009-2797(74)90019-2

Cited by 293 publications

(205 citation statements)

References 8 publications

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“…Similar results were found by El-Nahas, Mattar and Mohamed (1993), who found that vitamins C and E (100 and 300 mg.kg -1 .day -1 ), in a six month-treatment, showed no cytotoxic or mutagenic activity in albino rats. Cameron and Campbell (1974) also reported good clinical response on palliative treatment in 55 advanced cancer patients with the continuous administration of high doses of ascorbic acid.…”

Section: Bone Marrow Cells Of Wistar Ratsmentioning

confidence: 93%

Investigation of cytotoxic and mutagenic effects of Malpighia glabra L. (barbados cherry) fruit pulp and vitamin C on plant and animal test systems

et al. 2012

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Fruits are important sources of nutrients in human diet, and Barbados Cherry (Malpighia glabra L.) is of particular interest due to its high content of antioxidants. Diets rich in fruits and vegetables protect individuals against diseases and cancer, but excessive intake of vitamins may act as pro-oxidant and generate changes in DNA. To evaluate the effect of different in natura (BAN) and frozen (BAF) Barbados Cherry pulp concentrations and synthetic vitamin C in liquid form (VC) on the chromosome level and the cell cycle division, root meristeme cells of Allium cepa L. and bone marrow cells of Wistar rats Rattus norvegicus, were used as test system. In Allium cepa L., BAN, at the highest concentration (0.4 mg.mL-1) and BAF, at the lowest concentration (0.2 mg.mL-1), inhibited cell division, and there was recovery of cell division after the recovery period in water only for BAN. In the Wistar rats, all treatments with Barbados Cherry, either acute or subchronic, were not cytotoxic or mutagenic; only the highest concentration of VC increased significantly the rate of chromosomal abnormalities. The data obtained are important to reinforce the use of Barbados Cherry fruit in the diet.

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Section: Bone Marrow Cells Of Wistar Ratsmentioning

confidence: 93%

Investigation of cytotoxic and mutagenic effects of Malpighia glabra L. (barbados cherry) fruit pulp and vitamin C on plant and animal test systems

et al. 2012

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“…It was demonstrated by Cameron et al [133][134][135], that high-dose vitamin C improved the survival of patients with terminal cancer. However, the first documented study in which vitamin C was administered to cancer patients was carried out in the 1970s, by Pauling and Cameron.…”

Section: Vitamin C and Cancermentioning

confidence: 99%

Vitamin C in Disease Prevention and Cure: An Overview

et al. 2013

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The recognition of vitamin C is associated with a history of an unrelenting search for the cause of the ancient haemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential for the development and maintenance of connective tissues. It plays an important role in bone formation, wound healing and the maintenance of healthy gums. Vitamin C plays an important role in a number of metabolic functions including the activation of the B vitamin, folic acid, the conversion of cholesterol to bile acids and the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. It is an antioxidant that protects body from free radical damage. It is used as therapeutic agent in many diseases and disorders. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight off infections. However the significance and beneficial effect of vitamin C in respect to human disease such as cancer, atherosclerosis, diabetes, neurodegenerative disease and metal toxicity however remains equivocal. Thus further continuous uninterrupted efforts may open new vistas to understand its significance in disease management.

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“…This poor correction, due to grossly inadequate maternal daily intakes of ascorbate, continues throughout the lifetime of the victims, exposing them constantly to the deleterious physiological insults of Chronic Subclinical Scurvy (the CSS Syndrome)…" [23].…”

Section: Source Of Every Diseasementioning

confidence: 99%

“…We and other workers in this field haven't really realized the enormous size of daily dosage of ascorbate required for therapy and survival in cancer!" [23,24].…”

Section: Mega-doses Of Vitamin C and Cancermentioning

confidence: 99%

The Cure from Nature: The Extraordinary Anticancer Properties of Ascorbate (Vitamin C)

Milardi¹,

Massai²

2016

J Integr Oncol

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The anticancer properties of Vitamin C (ascorbic acid o sodium ascorbate) are known since at least four decades, However, being a cheap and "natural" product, Vitamin C is not patentable and therefore has never been developed as an anticancer molecule.Recent in vitro investigations have confirmed the extraordinary antitumor properties of high doses of Vitamin C (sodium ascorbate), particularly when administered by the intravenous route, and phase I/II randomized, controlled clinical trials have been started to verify its anticancer properties in vivo.Unfortunately, the controlled clinical trials performed so far, do not confirm the extraordinary results obtained with Vitamin C (sodium ascorbate) in vitro. However, this may depend on a number of different factors, such as the pharmaceutical preparation (Sodium ascorbate may be more suitable than buffered ascorbic acid), the schedule of administration (slow infusion better than rapid infusion), tumor tissue oxygenation (Cancer tissue oxygenation is lower that oxygenation of tumor cell lines, in vitro), etc., which deserve further in depth investigation.Even with these limitations, Vitamin C (sodium ascorbate) in high doses, administered by intravenous route, beyond being extremely effective in vitro, against a number of human tumor cell lines, is safe, has minimal contraindications, improves the quality of life of patients, and is highly selective for cancer cells.The Authors discuss these important aspects and suggest possible solutions to improve the in vivo anticancer effects of Vitamin C (sodium ascorbate).

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The orthomolecular treatment of cancer II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer

Cited by 293 publications

References 8 publications

Investigation of cytotoxic and mutagenic effects of Malpighia glabra L. (barbados cherry) fruit pulp and vitamin C on plant and animal test systems

Investigation of cytotoxic and mutagenic effects of Malpighia glabra L. (barbados cherry) fruit pulp and vitamin C on plant and animal test systems

Vitamin C in Disease Prevention and Cure: An Overview

The Cure from Nature: The Extraordinary Anticancer Properties of Ascorbate (Vitamin C)

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