The Oropharynx as a Distinct Colonization Site for<i>staphylococcus aureus</i>in the Community

Hanson, Blake; Kates, Ashley E.; E, Mills; Herwaldt, Loreen A.; Torner, James C.; Dawson, Jeffrey D.; Smith, Tara C.

doi:10.1101/137901

Cited by 3 publications

(5 citation statements)

References 37 publications

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“…These studies noted occurrence rates ranging from 10.5% to 26% (Amala et al, 2015;Onaolapo et al, 2015;Owaku et al, 2018;Abiose 2019;Akinrotoye et al, 2019) but lower than the 56.48% and 66.7% described in a 2017 study(Akinjogunla and Divine-Anthony, 2017). S. aureus in a known commensal carried in the nasopharyngeal region by up to 30% of the human population (Hanson et al,2017). The presence of this organism on door handles could therefore represent poor hygiene practices involving contact of the hand and nose and a lack of proper hand hygiene.…”

Section: Resultsmentioning

confidence: 99%

Assessment of Door Handles as Potential Reservoirs of Multidrug Resistant Staphylococcus aureus in Rivers State, Nigeria

Chukwunta¹

2021

Int.J.Curr.Microbiol.App.Sci

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Section: Resultsmentioning

confidence: 99%

Assessment of Door Handles as Potential Reservoirs of Multidrug Resistant Staphylococcus aureus in Rivers State, Nigeria

Chukwunta¹

2021

Int.J.Curr.Microbiol.App.Sci

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“…Colonization of S. aureus in the nose and pharynx is a multifactorial process that involves genetic aspects of the host, virulence factors of the pathogen, and possible interactions between the microbiota of the host [14], although in principle it is thinks that colonization of the pharynx is secondary to colonization of the nose, it is likely that both processes are independent [15].…”

Section: Introductionmentioning

confidence: 99%

Factors of Nasopharynx that Favor the Colonization and Persistence of Staphylococcus aureus

González-García¹,

Hamdan-Partida²,

Bustos-Hamdan³

et al. 2021

Pharynx - Diagnosis and Treatment

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Between 30 and 50% of the world population is permanently colonized in some anatomical site by Staphylococcus aureus, although the vast majority are asymptomatic carriers. The nose is its main niche and currently the colonization of S. aureus in the pharynx has become relevant due to the variety of reported carrier rates and the epidemiological importance of the dissemination of Methicillin-resistant S. aureus strains (MRSA) by pharyngeal carriers. For this bacterium to colonize a tissue successfully, it is necessary to establish many interactions with bacterial and host cell components such as bacterial wall teichoic acids (WTA) with the Scavenger SREC-1 host receptor and at the same time evade the defense mechanisms. On the other hand, there are host factors that will facilitate or complicate the colonization or persistence of S. aureus at these sites, such as physiological, genetic, immunological and microbiological factors.

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“…In the longitudinal study, 12 of the 129 adults were oropharynx only colonizers and 22 were colonized in both the nose and throat. In the longitudinal portion of this study, the throat was again found to be more sensitive than the nose in identifying S. aureus carriers (77.3% vs. 72.7% respectively) [41,42]. In this study, 72 participants (47.4%) were categorized as non-carriers, 49 (32.2%) were categorized as intermittent carriers, and 31 (20.4%) were categorized as persistent carriers [42].…”

Section: Colonization With S Aureusmentioning

confidence: 89%

“…However, this may be due to sampling bias as the number of studies examining the nose as a colonization site far exceeds any other body site. Other body sites known to carry S. aureus are: skin [39], perineum [40], oropharynx [39,[41][42][43][44] gastrointestinal tract [45][46][47], axilla [48], and vagina [39,48] (Figure 2-1 were colonized with S. aureus at baseline in either the nose or throat [42]. Thirty-three of the 79 were colonized only in their throat and 35 in both their nose and throat.…”

Section: Colonization With S Aureusmentioning

confidence: 99%

“…Additionally, in the Hanson et al prospective cohort study, it was found that adults persistently colonized with S. aureus preferentially colonized the oropharynx. This study found several risk factors that increased the risk of oropharyngeal colonization including, environmental contamination, family size, and race [41,42].…”

Section: Risk Factors For Colonization With S Aureusmentioning

confidence: 99%

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The human nasal and oropharyngeal microbiomes and Staphylococcus aureus colonization

Kates¹

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Staphylococcus aureus has been extensively studied, yet it remains unclear why certain individuals continually carry the bacteria while others do not. Livestock workers are known to be at an increased risk of S. aureus colonization, but have not been as studied as other high risk groups, including hospitalized patients, have been. Culture based studies have shown other bacteria may decrease the likelihood of S. aureus colonization. Here, we utilize 16s rRNA sequencing to better characterize the ecologic relationships between S. aureus and the other microbes in the nares and oropharynx in a population of livestock workers.A cross-sectional, epidemiological study was conducted enrolling 59 participants (26 of which had livestock contact) in Iowa. Participants were enrolled in one of four ways: from an existing prospective cohort study (n=38), from the Iowa Department of Natural Resources Animal Feeding Operations database (n=17), through Iowa county fairs (n=3), and through snowball sampling (n=1). We collected two sets of swabs from the nares and oropharynx of each participant. The first set of swabs was used to assess the microbiome via 16s rRNA sequencing and the second was used to culture S. aureus.We observed livestock workers to have greater diversity in their microbiomes compared to those with no livestock contact. In the nares, there were 26 operational taxonomic units found to be different between livestock workers and non-livestock workers with the greatest difference seen with Streptococcus and Proteobacteria. In the oropharynx, livestock workers with swine exposure were more likely to carry several pathogenic organisms. We also observed colonized livestock workers to be more likely to

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The Oropharynx as a Distinct Colonization Site forstaphylococcus aureusin the Community

Cited by 3 publications

References 37 publications

Assessment of Door Handles as Potential Reservoirs of Multidrug Resistant Staphylococcus aureus in Rivers State, Nigeria

Assessment of Door Handles as Potential Reservoirs of Multidrug Resistant Staphylococcus aureus in Rivers State, Nigeria

Factors of Nasopharynx that Favor the Colonization and Persistence of Staphylococcus aureus

The human nasal and oropharyngeal microbiomes and Staphylococcus aureus colonization

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