The origin of faecal fat.

Wiggins, H. S.; Howell, Kathryn E.; Kellock, T. D.; Stalder, J.‐F.

doi:10.1136/gut.10.5.400

Cited by 31 publications

(7 citation statements)

References 9 publications

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“…However, there are still small amounts of fat entering the large intestine as has been shown by ileostomy studies [16][17][18]. In addition, the fatty acid composition of ileostomy effluent resembles that of the diet [18]. A high fat diet can alter the composition of colonic microbiota.…”

Section: Effects Of High Fat Diet On Gut Microbiotamentioning

confidence: 98%

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Impact of high fat diets, prebiotics and probiotics on gut microbiota and immune function, with relevance to elderly populations

Liu¹,

Gibson²,

Walton

2016

NUA

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Abstract. According to WHO, the number of people over 60 years of age is set to rise to 2 billion by 2050. Dysbiosis of microbial composition and impaired immune function have been observed in elderly persons compared to younger adults. As a result, the aging population has a higher disease risk than other age groups. In addition, high fat intakes have been observed to exert negative effects on microbial composition and immune function in murine studies. Elderly people have higher fat intakes than recommended levels, and this may make them more vulnerable to disease risk. Therefore, the impact of high fat consumption on elderly populations may be of relevance. Prebiotics and probiotics have been shown to have positive effects on microbiota composition and immune function in the elderly. This review describes aged-related changes in gut microbiome of elderly persons. It will also summarise studies concerning the impact of prebiotics, probiotics and high fat diets on microbiota composition and immune function.

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Section: Effects Of High Fat Diet On Gut Microbiotamentioning

confidence: 98%

“…In addition, high fat diets have also been seen to have an impact on the microbiota [13][14][15]. Although most dietary fat is digested in the small intestine, there are still small amounts entering the large intestine [16][17][18].…”

Section: Microbiota Of the Gastrointestinal Tractmentioning

confidence: 99%

Impact of high fat diets, prebiotics and probiotics on gut microbiota and immune function, with relevance to elderly populations

Liu¹,

Gibson²,

Walton

2016

NUA

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“…Previously, it was thought that 93%-97% of this fat was absorbed and that this percentage capability extended up to an intake of 200 g/24 h [482]. This relationship was recognized not to hold for neonates, whose stool fat may normally exceed 10% of intake [11].…”

Section: Qualitative Fecal Fat Testsmentioning

confidence: 99%

Approach to the Patient with Diarrhea

Powell¹

2008

Principles of Clinical Gastroenterology

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“…A major factor indeterminingthedifferences is bacterial action within the colon (Wiggins, Howell, Kellock, and Stalder, 1969), and one product of this process is hydroxystearic acid (OHSA) which has been identified in the stools in normal subjects and in various disease states (Chipault, 1953;James, Webb, and Kellock, 1961;Rosenfeld and Hellman, 1962;Gompertz and Sammons, 1963). The proportion of OHSA varies in different conditions and it has been proposed that this may be of value in clinical diagnosis (Kim and Spritz, 1968a).…”

mentioning

confidence: 99%

Incidence and significance of faecal hydroxystearic acid in alimentary disease

Wiggins¹,

Pearson²,

Walker³

et al. 1974

Gut

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SUMMARY Three-day faecal collections were obtained from 87 patients with a variety of gastroenterological diagnoses and 12 control subjects while consuming normal diets. Faecal weight, total fatty acids, and the proportion of hydroxystearic (OHSA) acid were measured. All patients had some easily detectable hydroxystearic acid. It was found that in general the percentage of OHSA in the faecal fatty acids increased with increasing fat output. Thus most patients excreting less than 20 g of fat per day had less than 5 % OHSA while those with greater steatorrhoea had levels of 6 to 23 %. Exceptions were patients with mild steatorrhoea with ileal disease, ileal resections, or small intestinal bacterial colonization, who had more than 5 % OHSA whilst patients with colonic resection had much lower levels of OHSA than otherwise found. It is impossible to determine whether OHSA had a specific cathartic action from this study since the data implicated total fatty acids to the same extent.

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The origin of faecal fat.

Cited by 31 publications

References 9 publications

Impact of high fat diets, prebiotics and probiotics on gut microbiota and immune function, with relevance to elderly populations

Impact of high fat diets, prebiotics and probiotics on gut microbiota and immune function, with relevance to elderly populations

Approach to the Patient with Diarrhea

Incidence and significance of faecal hydroxystearic acid in alimentary disease

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