The origin of certain non‐medullated nerve fibres which form synapses in the inferior mesenteric ganglion of the rabbit

McLennan, H.; Pascoe, Judith

doi:10.1113/jphysiol.1954.sp005093

Cited by 39 publications

(17 citation statements)

References 11 publications

(12 reference statements)

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“…There have been a number of previous studies which suggest that enteric neurones may give rise to axons which synapse in the IMG (Garry, 1933;Lawson, 1934;Lawson & Holt, 1937;Kuntz, 1940;Kuntz & Saccomanno, 1944;Job & Lundberg, 1952;McLennan & Pascoe, 1954). Our electrophysiological observations at the single unit level strongly support this hypothesis.…”

Section: Discussionsupporting

confidence: 81%

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Excitatory input from the distal colon to the inferior mesenteric ganglion in the guinea‐pig

Crowcroft¹,

Holman²,

Szurszewski³

1971

The Journal of Physiology

164

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4. The excitatory activity was irreversibly abolished when the lumbar colonic nerves were cut and reversibly abolished when tetrodotoxin (5 x 1O-7 g/ml.) was added to the colon side of a two-compartment organ bath.5. Addition of dihydro-,8-erythroidine (5 x 10-g/ml.) to the ganglion side of the bath abolished the synaptic activity of colonic origin and the synaptic responses to stimulation of any of the nerve trunks connected to the IMG.6. Addition of dihydro-fi-erythroidine (1 x 10-5 g/ml.) to the colon side of the bath markedly depressed the synaptic input of colonic origin but had no effect on synaptic responses produced by preganglionic nerve stimulation.7. Distension of the colonic segment and the application of 5-HT (1 x 10-5 g/ml.) to the mucosal surface of the colon increased the frequency of synaptic input. P. J. CR0 WOROFT AND OTHERS 8. The synaptic input from the colon was transiently blocked following repetitive stimulation of any of the nerve trunks connected to the IMG. The discharge of miniature synaptic potentials was unaffected.

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Section: Discussionsupporting

confidence: 81%

“…16 that they may receive input from peripheral cholinergic neurones other than those within the wall of the colon. This possibility follows from the work of McLennan & Pascoe (1954) who found evidence in the rabbit that IMG cells could be excited by fibres which did not appear to be of central origin.…”

Section: Discussionmentioning

confidence: 87%

Excitatory input from the distal colon to the inferior mesenteric ganglion in the guinea‐pig

Crowcroft¹,

Holman²,

Szurszewski³

1971

The Journal of Physiology

164

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“…Even the slow C fibres that run in the sympathetic nerves from the colon to the inferior mesenteric ganglion conduct at about 250 cm/sec (Brown & Pascoe, 1952;McLennan & Pascoe, 1954). There is, however, another possibility, that of conduction in the smooth muscle of the vessel wall.…”

Section: Resultsmentioning

confidence: 94%

A peripheral arterial conducting mechanism underlying dilatation of the femoral artery and concerned in functional vasodilatation in skeletal muscle

Hilton¹

1959

The Journal of Physiology

200

105

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The concept of vasodilator metabolites diffusing through the interstitial fluid to act directly on the vessel walls has never accounted adequately for the vasodilatation observed in a contracting muscle; for this dilatation is not confined to the capillaries and arterioles, but extends to the small intramuscular arteries and even to the larger arteries outside the muscle. In previous experiments, in which the vasodilatation was registered by the increase in venous outflow from the muscle, the post-contraction hyperaemia was thought to be produced in the main by an axon reflex in vasodilator nerve fibres, for it was grossly impaired by local anaesthetics, botulinum toxin or large, 'paralysing' doses of nicotine (Hilton, 1953(Hilton, , 1954. However, the nature of any nerve fibres involved remained obscure, since the post-contraction hyperaemia was not affected by chronic lumbar sympathectomy or posterior root ganglionectomy.It was shown over twenty years ago that the femoral artery itself dilates after contraction of the muscles of the lower leg, even when all the nerves to the limb are divided (Schretzenmayr, 1933;Fleisch, 1935). This reaction therefore had also been thought to be due to an axon reflex. It was abolished by local application to the artery, below the site of measurement, of phenol or cocaine, hence the responsible conducting elements appeared to run in the artery wall. Experiments now carried out on this dilator response of the femoral artery have confirmed these findings. Further, the femoral artery response has been found to be affected by drugs and surgical procedures in exactly the same way as the major part of the post-contraction hyperaemia. They both appear to be part of one and the same vascular reaction with a common conducting mechanism, and, since no known system of nerve fibres can be shown to be responsible, it is suggested that the conduction is effected by the smooth muscle of the artery wall.

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“…However, the response recorded in the side branch did not contain a hexamethonium-sensitive late component that would correspond to excitation of the post-ganglionic neurones in the intestinal nerve and conduction of an efferent discharge along their collaterals (see, for example, Fig. 2, McLennan & Pascoe, 1954).…”

Section: Discussionmentioning

confidence: 99%

Evidence That Enteric Cholinergic Neurones Project Orally in the Intestinal Nerve of the Chicken

Hodgkiss

1984

Exp Physiol

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SUMMARYThe intestinal nerve of the chicken, which runs almost the whole length of the small and large intestine, was studied in vitro, using suction electrodes for stimulation and recording. Lengths of nerve with side branches intact in the region of the ileum and rectum were used. The spike discharges that were evoked by supramaximal stimulation of a side branch were recorded at oral and aboral ends of the main nerve trunk. Exposure of the preparation to hexamethonium (550 /tM) reversibly abolished or greatly reduced the amplitude of the largest component of the evoked oral response in eighteen experiments, but was without effect on the evoked aboral response in ten experiments. No evidence of a nicotinic cholinergic component to the evoked aboral response was obtained at distances up to 12 5 mm along the nerve. There was also no evidence for a projection of post-ganglionic neurones along the stimulated side branch. The mean conduction velocity of the preganglionic nerve fibres was 0 25 + 0-02 m . s-1 while that for the post-ganglionic nerve fibres was 0 66+0-11 m. s-. These results suggest that both groups of nerve fibres are non-myelinated. 8-16 d after side branch transection, stimulation of the side branch evoked no oral response in five experiments and a hexamethonium-insensitive response in seven others. In a further four experiments a hexamethonium-sensitive component was seen, but it constituted only a small part of the evoked oral response. It is postulated that transection results in the degeneration of cholinergic nerves in the intestinal nerve. The results suggest that enteric cholinergic nerves form part of a pathway which projects orally along the ileal and rectal segments of the intestinal nerve.

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The origin of certain non‐medullated nerve fibres which form synapses in the inferior mesenteric ganglion of the rabbit

Cited by 39 publications

References 11 publications

Excitatory input from the distal colon to the inferior mesenteric ganglion in the guinea‐pig

Excitatory input from the distal colon to the inferior mesenteric ganglion in the guinea‐pig

A peripheral arterial conducting mechanism underlying dilatation of the femoral artery and concerned in functional vasodilatation in skeletal muscle

Evidence That Enteric Cholinergic Neurones Project Orally in the Intestinal Nerve of the Chicken

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