The orientation of the neuronal growth process can be directed via magnetic nanoparticles under an applied magnetic field

Riggio, Cristina; Calatayud, Mp; Giannaccini, Maria Elena; Sanz, Beatriz; Torres, Te; Fernández-Pacheco, Rodrigo; Ripoli, A; Ibarra,; Dente, Luciana; Cuschieri, Alfred; Goya, G.F.; Raffa, Vittoria

doi:10.1016/j.nano.2013.12.008

Cited by 94 publications

(127 citation statements)

References 49 publications

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“…Transplanting cells loaded with SPIONs can be successfully delivered to the specific injury tissue using applied fields (Nishida et al, 2006; Song et al, 2010; Fujioka et al, 2012). In addition, a more recent study has confirmed that the orientation of the neuronal growth process can be directed via magnetic nanoparticles under an applied MF (Riggio et al, 2014). Thus, if SPIONs are incorporated into SCs, a strong magnet could exert force upon the intracellular SPIONs and thus direct the migration of SCs into the astrocyte-rich area and increase the intermingling of SCs and astrocytes.…”

Section: Introductionmentioning

confidence: 89%

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Superparamagnetic Iron Oxide Nanoparticle-Mediated Forces Enhance the Migration of Schwann Cells Across the Astrocyte-Schwann Cell Boundary In vitro

Huang

Xia

Liu

et al. 2017

Front. Cell. Neurosci.

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Schwann cells (SCs) are one of the most promising cellular candidates for the treatment of spinal cord injury. However, SCs show poor migratory ability within the astrocyte-rich central nervous system (CNS) environment and exhibit only limited integration with host astrocytes. Our strategy for improving the therapeutic potential of SCs was to magnetically drive SCs to migrate across the astrocyte-SC boundary to intermingle with astrocytes. SCs were firstly magnetized with poly-L-lysine-coated superparamagnetic iron oxide nanoparticles (SPIONs). Internalization of SPIONs showed no effect upon the migration of SCs in the absence of a magnetic field (MF). In contrast, magnetized SCs exhibited enhanced migration along the direction of force in the presence of a MF. An inverted coverslip assay showed that a greater number of magnetized SCs migrated longer distances onto astrocytic monolayers under the force of a MF compared to other test groups. More importantly, a confrontation assay demonstrated that magnetized SCs intermingled with astrocytes under an applied MF. Furthermore, inhibition of integrin activation reduced the migration of magnetized SCs within an astrocyte-rich environment under an applied MF. Thus, SPION-mediated forces could act as powerful stimulants to enhance the migration of SCs across the astrocyte-SC boundary, via integrin-mediated mechanotransduction, and could represent a vital way of improving the therapeutic potential of SCs for spinal cord injuries.

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Section: Introductionmentioning

confidence: 89%

“…Then, the specimens were dehydrated in ascending alcohols. After drying, specimens were embedded in a solution of TAAB resin (TAAB Laboratories, England, UK) and cut in 70 nm thin slices (Riggio et al, 2014). The ultrathin sections were examined under a transmission electron microscope (HITACHI, Japan).…”

Section: Methodsmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticle-Mediated Forces Enhance the Migration of Schwann Cells Across the Astrocyte-Schwann Cell Boundary In vitro

Huang

Xia

Liu

et al. 2017

Front. Cell. Neurosci.

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“…Under the infl uence of a magnetic fi eld, these nanoparticles provide tension to specifi c areas inside the cell that encourages growth along the axis of the magnetic fi eld (Riggio et al 2014 ). Nanoparticles doped with cell adhesion molecules, which can be localized to the cell membrane, have been used to apply tension to the surface of a cell.…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Neural Engineering

2016

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“…With this construction in mind we proceeded to show that systems with homogenous neurons and a fixed number of such neurons (albeit large at the moment) are universal. This is a significant result in the area as we are moving closer to a wet-lab implementation of these results: recent reports in the area of nanotechnology applied to neurons (the real cells in the human or mouse body) show that we can re-wire a neuronal network and influence the axon and synapse growth and even design networks with different topologies of real neurons, glia and synapses between neurons by using nanoparticles such as gallium phosphide, magnetic fields and other techniques [1], [18], [16]. This, combined with recent simulation techniques [20], [21] and HPC resources [11] might eventually lead to implementations of networks of real neurons.…”

Section: Introductionmentioning

confidence: 99%

Three Universal Homogeneous Spiking Neural P Systems Using Max Spike

Păun

Sosík

2014

Fundamenta Informaticae

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We improve and extend a recent result showing that spiking neural P systems with the same rules in all neurons of the system (homogenous) and working in the max sequential manner are universal. The previous work in this area reported by the group led by Dr. Linqiang Pan did not put any bound on the number of neurons used. We believe this is an important question for any future practical implementation of such systems that deserves investigation, and we provide some results in this direction. Extending the aforementioned construction with the work of Korec on small register machines one could estimate the size of the previous construction at 105 neurons. We are able to improve this result and to show that an SNP system with 83 neurons having homogenous rules and working in the max sequential manner is universal. Several related results with respect to max-pseudo sequentiality mode are also obtained: 83 neurons are necessary for this case, too. When considering the case of systems without weighted synapses, we show that one needs at most 244 homogenous neurons for reaching universality in the max-pseudo sequentiality case.

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The orientation of the neuronal growth process can be directed via magnetic nanoparticles under an applied magnetic field

Cited by 94 publications

References 49 publications

Superparamagnetic Iron Oxide Nanoparticle-Mediated Forces Enhance the Migration of Schwann Cells Across the Astrocyte-Schwann Cell Boundary In vitro

Superparamagnetic Iron Oxide Nanoparticle-Mediated Forces Enhance the Migration of Schwann Cells Across the Astrocyte-Schwann Cell Boundary In vitro

Neural Engineering

Three Universal Homogeneous Spiking Neural P Systems Using Max Spike

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