The oralome and its dysbiosis: New insights into oral microbiome-host interactions

Radaic, Allan; Kapila, Yvonne

doi:10.1016/j.csbj.2021.02.010

Cited by 194 publications

(143 citation statements)

References 376 publications

(402 reference statements)

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“…The "Keystone-Pathogen Hypothesis", of which Porphyromonas gingivalis ( P. gingivalis) plays a key role, postulates that specific bacteria in limited quantities can influence the host immune system and switch the microbiota from symbiotic to dysbiotic to induce inflammatory disorder [ 14 ]. The virulence characteristics assigned to these specific periodontal pathogens make them potential contributors in adverse pregnancy outcomes [ 13 , 15 ]. As well, increased proportion of bleeding periodontal sites would induce hematological dissemination of periodontal pathogens and their products, and subsequently would later lead to an immune/inflammatory reaction in the feto-placental unit [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Periodontal Conditions and Pathogens Associated with Pre-Eclampsia: A Scoping Review

Gare

Kanouté

Méda

et al. 2021

IJERPH

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Background: Pre-eclampsia, the second most frequent direct source of maternal mortality, is a multisystem gestational disorder characterized by proteinuria and maternal hypertension after the 20th gestational week. Although the causes of pre-eclampsia are still discussed, research has suggested that the placenta has a central place in the pathogenesis of this disease. Moreover, current surveys indicated that periodontal disorders observed during the pregnancy and more particularly, periodontal pathogens could be link to the risk of pre-eclampsia. Objectives: This article aims to review recent studies focusing on periodontal conditions and pathogens associated with pre-eclampsia. Methods: The process followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. Results: Metabolic conditions, immunological changes, fluctuating progesterone and estrogen levels of the pregnant woman induce a dysbiosis of the oral microbiota and contribute to increase inflammation of periodontal tissues. Periodontal pathogens could diffuse through the bloodstream inducing a placenta inflammatory response as well as inflammatory molecules produced in response to periodontopathogens could migrate through the bloodstream leading to a placenta inflammatory response. Also, periodontopathogens can colonize the vaginal microbiota through the gastrointestinal tract or during oro-genital contacts. Conclusion: A cumulative bi-directional relationship between periodontal conditions, pathogens and the pre-eclampsia exists.

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Section: Introductionmentioning

confidence: 99%

Periodontal Conditions and Pathogens Associated with Pre-Eclampsia: A Scoping Review

Gare

Kanouté

Méda

et al. 2021

IJERPH

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“…The ecological niches occupied by bifidobacteria are not limited to the intestines of mammals, birds, and social insects [8][9][10][11][12]. Bifidobacteria are also found in the human oral cavity and play a dual role there in relation to dental and gum health [13,14]. B. dentium is associated with caries and tooth decay [15].…”

Section: Introductionmentioning

confidence: 99%

The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host’s Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19

Nezametdinova

Yunes

Dukhinova

et al. 2021

IJMS

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Bifidobacteria are some of the major agents that shaped the immune system of many members of the animal kingdom during their evolution. Over recent years, the question of concrete mechanisms underlying the immunomodulatory properties of bifidobacteria has been addressed in both animal and human studies. A possible candidate for this role has been discovered recently. The PFNA cluster, consisting of five core genes, pkb2, fn3, aaa-atp, duf58, tgm, has been found in all gut-dwelling autochthonous bifidobacterial species of humans. The sensory region of the species-specific serine-threonine protein kinase (PKB2), the transmembrane region of the microbial transglutaminase (TGM), and the type-III fibronectin domain-containing protein (FN3) encoded by the I gene imply that the PFNA cluster might be implicated in the interaction between bacteria and the host immune system. Moreover, the FN3 protein encoded by one of the genes making up the PFNA cluster, contains domains and motifs of cytokine receptors capable of selectively binding TNF-α. The PFNA cluster could play an important role for sensing signals of the immune system. Among the practical implications of this finding is the creation of anti-inflammatory drugs aimed at alleviating cytokine storms, one of the dire consequences resulting from SARS-CoV-2 infection.

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“…The mammalian gut microbiota is dominated by anaerobic bacteria belonging to the Bacteroides and Firmicutes phyla [ 10 ]. In addition to the intestinal microbiome, the oral microbiome represents a highly diverse ecosystem that likewise affects mucosal remodeling processes [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis

et al. 2021

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The gastrointestinal tract is a functionally and anatomically segmented organ that is colonized by microbial communities from birth. While the genetics of mouse gut development is increasingly understood, how nutritional factors and the commensal gut microbiota act in concert to shape tissue organization and morphology of this rapidly renewing organ remains enigmatic. Here, we provide an overview of embryonic mouse gut development, with a focus on the intestinal vasculature and the enteric nervous system. We review how nutrition and the gut microbiota affect the adaptation of cellular and morphologic properties of the intestine, and how these processes are interconnected with innate immunity. Furthermore, we discuss how nutritional and microbial factors impact the renewal and differentiation of the epithelial lineage, influence the adaptation of capillary networks organized in villus structures, and shape the enteric nervous system and the intestinal smooth muscle layers. Intriguingly, the anatomy of the gut shows remarkable flexibility to nutritional and microbial challenges in the adult organism.

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The oralome and its dysbiosis: New insights into oral microbiome-host interactions

Abstract: Graphical abstract

Cited by 194 publications

References 376 publications

Periodontal Conditions and Pathogens Associated with Pre-Eclampsia: A Scoping Review

Periodontal Conditions and Pathogens Associated with Pre-Eclampsia: A Scoping Review

The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host’s Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19

The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis

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