The optimal cut-off of blood pressure related to left ventricular diastolic dysfunction and remodeling in Asian diabetic patients

Jung, Ju Young; Park, Sung Keun; Ryoo, Jae‐Hong; Oh, Chang‐Mo; Kang, Jeong Gyu; Moon, Kanghee; Lee, Keum Ok; Choi, Joong-Myung

doi:10.1016/j.jjcc.2017.06.008

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…Recent studies have reported that LV diastolic dysfunction is caused by inflammation and oxidative stress, which are known to be induced by several factors, including diabetes, hypertension, and age [16,17]. Clinical studies also reported that diabetes, hypertension, and age showed independent associations with LV diastolic dysfunction [18,19]. In the current study, age, hypertension, and some medications for hypertension were independently associated with LV diastolic dysfunction.…”

Section: Discussionsupporting

confidence: 56%

The impact of peripheral artery disease on left ventricular diastolic function

Yanaka

Akahori

Imanaka

et al. 2019

Journal of Cardiology

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Background: Peripheral artery disease (PAD) is often accompanied by heart failure with preserved ejection fraction (HFpEF). Left ventricular (LV) diastolic dysfunction is related to HFpEF. The aim of this study was to compare LV diastolic function between patients with or without PAD. Methods: One thousand one hundred twenty-one patients (male 56%, mean age 68 AE 13 years) with available preserved LV systolic function assessed by echocardiography (ejection fraction !50%) were enrolled from a single-center database between January 2013 and May 2015. PAD was defined as ankle brachial index <0.9 or previous history of lower extremity bypass and/or endovascular therapy. Diagnosis of LV diastolic dysfunction was based on the American Society of Echocardiography and European Association of Cardiovascular Imaging guidelines. The prevalence of LV diastolic dysfunction was compared between patients with PAD and those without PAD.Multivariate analysis was performed by logistic regression analyses to assess predictors of LV diastolic dysfunction. Results: Two hundred patients (18%) had PAD. Patients with PAD had higher E/e 0 (15.3 AE 7.4 vs 11.8 AE 5.5, p < 0.01), tricuspid regurgitation velocity (2.37 AE 0.33 vs 2.19 AE 0.28 m/s, p < 0.01), left atrial volume index (40.6 AE 20.2 vs 32.1 AE 13.6 mL/m 2 [ 1 _ T D $ D I F F ] , p < 0.01), and lower e 0 (5.68 AE 1.70 vs 6.38 AE 2.07 cm/s, p < 0.01) than patients without PAD. The prevalence of LV diastolic dysfunction was higher (31% vs 12%, p < 0.01) in patients with PAD compared to patients without PAD. Multivariate analysis showed that PAD was an independent predictor of LV diastolic dysfunction (adjusted odds ratio: 1.77, 95% confidence interval: 1.13-2.65, p = 0.01). Conclusion:The prevalence of LV diastolic dysfunction was higher in patients with PAD than patients without PAD.

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Section: Discussionsupporting

confidence: 56%

The impact of peripheral artery disease on left ventricular diastolic function

Yanaka

Akahori

Imanaka

et al. 2019

Journal of Cardiology

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“…Previous studies observed that systolic blood pressure was associated with an increased risk of diastolic dysfunction 17,18 . Interestingly, in our study, we found that FH+ was independent predictor of diastolic dysfunction despite lower systolic blood pressure compared to those of FH–.…”

Section: Characteristics All Subjects (N = 1011) Fh+ (N = 251) Fh− (N...supporting

confidence: 52%

“…Previous studies observed that systolic blood pressure was associated with an increased risk of diastolic dysfunction. 17 , 18 Interestingly, in our study, we found that FH+ was independent predictor of diastolic dysfunction despite lower systolic blood pressure compared to those of FH–. Based on our multivariate analysis, it seems that FH+ impact on diastolic dysfunction surpassed that of systolic blood pressure.…”

Section: Tablementioning

confidence: 45%

Chronic complications risk among type 2 diabetes patients with a family history of diabetes

Tahapary,

Wafa,

Tricaesario

et al. 2023

Chronic Diseases and Translational Medicine

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“…Blood pressure <120 mm of Hg systolic and <80 mm of Hg diastolic was considered as normal. 22 Blood samples were collected and all the biochemical and laboratory investigations were performed for both PCOS patients and healthy controls. Pelvic ultrasound was also done for all study groups.…”

Section: Methodsmentioning

confidence: 99%

Oxidative stress in polycystic ovary syndrome: a case- control study

Syeda Samira Azim,

Zeba Haque,

Sadaf Khan

et al. 2024

J Pak Med Assoc

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Objective: To compare the serum levels of biochemical and oxidative stress markers i.e., malondialdehyde (MDA) and paraoxonase-1(PON1) in polycystic ovary syndrome (PCOS) patients and healthy female individuals of reproductive age group (18-40 years). Methods: This case-control study was conducted in Dow University of Health Sciences (DUHS), Karachi from June 2019 to October 2020. Seventy Subjects including 35 PCOS patients that have primary subfertility problem (cases) and 35 healthy and fertile females (controls) were recruited. Serum samples were collected for analysis of insulin, sex hormone-binding globulin, testosterone, fasting blood glucose and lipid profile. PON 1 and MDA levels were estimated by ELISA. Comparison between the two groups was done using independent t-test. Result: The patients had significantly increased mean body mass index (28.5+4.6 kg/m2 vs 25.7+4.5 kg/m2, p=0.014), systolic (129.6±13.9 mm of Hg vs 113±7.7 mm of Hg, p< 0.001) and diastolic (78.7±8.8 mm of Hg vs 74.6±6.7 mm of Hg, p=0.032) blood pressures compared to controls. The high-density lipoprotein cholesterol levels were significantly lower in PCOS (42.2±8.6mg/dl) than controls (48.8±11.8mg/dl, p=0.009, p=0.009). Serum insulin (14.3±5.8 µIU/mL) vs (10.0±5.2 µIU/mL), p=0.002 and testosterone levels (1.3±0.9 nmol/L) vs (0.82±0.3 nmol/L), p<0.001 were significantly higher whereas sex hormone binding globulin (SHBG) levels (35.2±19.7nmol/L vs 58.8±31.0 nmol/L) were significantly lower in patients than healthy controls (p<0.001). Both oxidative stress markers, paraoxonase 1 (7.7±2.4 vs 6.4±2.6 µg/mL, p=0.04) and malondialdehyde (2.5±1.0 vs 1.9+0.51µg/mL, p=0.034) levels were significantly elevated in PCOS patients than controls. No significant correlation was found between dietary habits and life style between cases and controls. Conclusion: The study reported significantly elevated levels of oxidative stress markers in PCOS patients. Keywords: Blood Glucose, Blood Pressure, Testosterone, Oxidative stress, Malondialdehyde, Lipoproteins, Cholesterol, Lipids, Enzyme.

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The optimal cut-off of blood pressure related to left ventricular diastolic dysfunction and remodeling in Asian diabetic patients

Abstract: Our study showed the adverse influence of prehypertension and hypertension on subclinical LV deterioration. This finding suggested the potential clinical benefits of intensive BP control (<130/80mmHg) in patients with DM.

Cited by 4 publications

References 35 publications

The impact of peripheral artery disease on left ventricular diastolic function

The impact of peripheral artery disease on left ventricular diastolic function

Chronic complications risk among type 2 diabetes patients with a family history of diabetes

Oxidative stress in polycystic ovary syndrome: a case- control study

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