The impact of peripheral artery disease on left ventricular diastolic function

Yanaka, Koji; Akahori, Hirokuni; Imanaka, Tadayuki; Miki, Kojiro; Yoshihara, Nagataka; Tanaka, Takamasa; Asakura, Masanori; Masuyama, Tohru; Ishihara, Masaharu

doi:10.1016/j.jjcc.2019.01.011

Cited by 12 publications

(12 citation statements)

References 31 publications

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“…As previously reported, low ABI has a poor prognosis [7][8][9][10]. In addition, lower ABI is associated with worse cardiac function [11], the severity of CAD [12,13], and moreover it is considered as an independent predictor of short-term clinical outcomes in patients who underwent PCI [14][15][16]. However, there is no report to examine the relationship between low ABI and long-term clinical outcomes after DES implantation.…”

Section: Introductionmentioning

confidence: 99%

Low ankle brachial index predicts poor outcomes including target lesion revascularization during the long-term follow up after drug-eluting stent implantation for coronary artery disease

Sasaki

Mitsutake

Ueno

et al. 2020

Journal of Cardiology

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Background: Peripheral arterial disease (PAD) frequently coexists with coronary artery disease (CAD). The ankle-brachial index (ABI) is widely used for the screening for PAD. Low ABI is associated with short-term clinical outcomes in patients receiving coronary drug-eluting stent (DES) implantation. However, there is no report to examine the relationship between lower ABI and long-term clinical outcomes after DES implantation. Thus, we investigated the clinical long-term impact of low ABI after DES implantation. Methods: This retrospective analysis included 181 CAD patients treated with DES from April 2010 to March 2013 in our institute. Based on ABI values, we divided the subjects into the low-ABI group(ABI [ 6 1 _ T D $ D I F F ] < 0.9, n = 29) and the normal ABI group(0.9 [ 6 2 _ T D $ D I F F ] ABI < 1.4, n = 152). The incidence of target lesion revascularization (TLR), all-cause mortality, and major adverse cardiac and cerebrovascular events (MACCE) defined as a composite of cardiac death, myocardial infarction, stroke, and any repeat revascularization, were compared between the 2 groups. Results: During the median follow-up period of 43 months, the incidences of TLR, all-cause mortality, and MACCE were significantly higher in the low ABI group than in the normal ABI group (TLR: 41.4% vs 9.9%, p [ 6 3 _ T D $ D I F F ] < 0.001, all-cause mortality: 31.0% vs 3.9%, p [ 6 3 _ T D $ D I F F ] < 0.001, MACCE: 48.3% vs 11.2%, p [ 6 3 _ T D $ D I F F ] < 0.001, respectively). Conclusions: Low ABI may predict poor long-term outcomes, including TLR, in CAD patients treated with DES.

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Section: Introductionmentioning

confidence: 99%

Low ankle brachial index predicts poor outcomes including target lesion revascularization during the long-term follow up after drug-eluting stent implantation for coronary artery disease

Sasaki

Mitsutake

Ueno

et al. 2020

Journal of Cardiology

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“…Recent studies have reported that patients with LEAD have an increased risk of LV diastolic dysfunction [12,13]. We evaluated whether LV diastolic dysfunction is associated with risk factors of MACCE.…”

Section: Discussionmentioning

confidence: 99%

Impact of left ventricular diastolic dysfunction on long-term outcome in patients with lower extremity artery disease

Yanaka

Akahori

Imanaka

et al. 2020

Journal of Cardiology

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The presence of lower extremity artery disease (LEAD) shows a high risk of coronary artery disease (CAD) and cerebrovascular diseases (CVD). LEAD is associated with significantly increased mortality and cardiovascular death [1][2][3][4][5]. LEAD is also a risk for heart failure (HF) [6]. Left ventricular (LV) systolic dysfunction, history of HF, and the presence of CAD were associated with an increased risk for mortality and cardiac events in patients with LEAD [7-9]. However, the impact of LV diastolic dysfunction on the long-term outcome of patients with LEAD has not been systematically studied. The aim of this study was to assess the impact of LV diastolic dysfunction on the long-term outcome in patients with LEAD. Materials and methods Study design and participantsThis study was a single center and retrospective analysis. Two hundred patients with LEAD whose ankle-brachial index (ABI) was measured within 3 months before or after echocardiography were enrolled between January 2013 and May 2015 from Hyogo College of Medicine. Exclusion criteria were ejection fraction (EF) <50 %, lack of data for echocardiography, or moderate-to-severe valvular disease. The 3-year cumulative incidence of primary and secondary endpoints was compared between LEAD patients with LV diastolic dysfunction and those without.

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“…Imaging guidelines for the diagnosis of LV diastolic dysfunction 19) . They showed a higher prevalence of LV diastolic dysfunction in patients with PAD (n = 200) regardless of the severity of PAD (non-PAD, n = 921).…”

Section: Diastolic Dysfunction and Padmentioning

confidence: 99%

Initial diastolic dysfunction is a powerful predictor of 5-year mortality in peripheral arterial disease patients undergoing percutaneous transluminal angioplasty

et al. 2021

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Background Peripheral arterial disease (PAD) and heart failure share common risks and are associated with increased morbidity and mortality. However, it is unknown whether cardiac function can be an independent predictor of long-term mortality in patients with PAD. Methods In total, 902 patients who underwent percutaneous transluminal angioplasty for PAD were enrolled. The patients were categorized into three groups according to the left ventricular ejection fraction (LVEF): reduced EF (< 40%, n = 62); mid-range EF (40-49%, n = 76); and preserved EF (≥ 50%, n = 764). Echocardiographic (EF, ratio of mitral in ow velocity to annular velocity E/e ≥ 15, and others) and clinical parameters were tested using stepwise logistic regression analysis to determine independent predictors of 5-year mortality. Results A higher proportion of patients with reduced EF had ischemic heart disease than those with preserved EF (77.4% vs. 56.8%, p < 0.001). Up to 5 years, patients with reduced EF and mid-range EF showed a higher incidence of total death than those with normal EF. However, there was no difference in the incidence of myocardial infarction, stroke, and revascularization among the three groups. After multivariable adjustment, the ratio of E/e ≥ 15 was the only strong predictor of total mortality (hazard ratio, 6.14; 95% con dence interval, 3.7-10.1;p < 0.01). Conclusion Patients with PAD and reduced EF undergoing PTA had a higher incidence of total death during the 5-year follow-up. Initial tissue Doppler E/e ≥ 15, a non-invasive estimate of left atrial lling pressure, was the only independent predictor of long-term mortality.

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The impact of peripheral artery disease on left ventricular diastolic function

Cited by 12 publications

References 31 publications

Low ankle brachial index predicts poor outcomes including target lesion revascularization during the long-term follow up after drug-eluting stent implantation for coronary artery disease

Low ankle brachial index predicts poor outcomes including target lesion revascularization during the long-term follow up after drug-eluting stent implantation for coronary artery disease

Impact of left ventricular diastolic dysfunction on long-term outcome in patients with lower extremity artery disease

Initial diastolic dysfunction is a powerful predictor of 5-year mortality in peripheral arterial disease patients undergoing percutaneous transluminal angioplasty

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