The opera prevention project

Muscogiuri, Giovanna; Barrea, Luigi; Laudisio, Daniela; Pugliese, Gabriella; Framondi, Lydia; Matteo, Rossana Di; Riccio, Pasquale Antonio; Savastano, Silvia; Colao, Annamaria

doi:10.1080/09637486.2020.1765152

Cited by 25 publications

(15 citation statements)

References 9 publications

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“…In agreement with these findings, data coming from the OPERA (Obesity, Programs of nutrition, Education, Research and Assessment of the best treatment) Prevention Project pointed out that individuals with the evening chronotype were, when compared to intermediate and morning chronotypes, more prone to follow an unhealthy lifestyle, performing less regular activity and being more frequent smokers [7,8]. In addition, they showed the lowest adherence to the Mediterranean Diet (MD) compared to the morning and intermediate chronotypes, and the lower their chronotype score, the higher the Body Mass Index (BMI) values in all populations, thus suggesting that the highest chronotype score was more commonly detected in subjects with obesity [9].…”

Section: Introductionsupporting

confidence: 52%

The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?

et al. 2021

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Chronotype is defined as the behavioral manifestation of circadian rhythms related to the external light–dark cycle. Evening chronotype has been associated with an increased risk of developing cardiometabolic diseases in obesity. Menopause is a lifestage associated with an increased risk of developing cardiometabolic diseases and a change in circadian rhythmicity compared to pre-menopause. However, the prevalence of chronotype categories in menopause and their role in determining menopause-related cardiometabolic risk, mostly in obesity, have not been investigated. Thus, we aimed to investigate the prevalence of chronotype categories in post-menopausal women with obesity and their role in menopause-related cardiometabolic risk. In this cross-sectional study we enrolled 49 pre-menopausal and 74 post-menopausal women with obesity. Anthropometric parameters, lifestyle habits, adherence to the Mediterranean Diet (MD), sleep quality, chronotype and the presence of type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD) were studied. No significance differences were detected in terms of lifestyle and adherence to the MD between pre- and post-menopausal women. Chronotype was classified as morning in 66 (53.6%), evening in 20 (16.3%) and intermediate in 37 (30.1%) women. In addition, pre-menopausal women with obesity showed a significantly higher chance to have an intermediate chronotype (OR = 2.21, 95% CI 1.28–3.83; p = 0.004), whereas post-menopausal women with obesity showed a trend to have a higher morning chronotype (OR = 1.42, 95% CI 0.98–2.06; p = 0.051), although this did not reach statistical significance. No significant differences were detected in terms of prevalence of evening chronotype between the two groups. However, the evening chronotype had a significantly higher risk to have T2DM compared to the morning (OR = 17.29, 95% CI 2.40–124.27; p = 0.005) and intermediate chronotypes (OR = 30.86, 95% CI 2.05–464.32; p = 0.013) in both pre- and post-menopausal women with obesity. In conclusion, the intermediate chronotype was significantly more prevalent in pre-menopausal women with obesity compared to post-menopausal women. Evening chronotype was associated to T2DM in both pre- and post-menopause. These results support the importance of including the assessment of chronotype in the management of women with obesity in post-menopause.

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Section: Introductionsupporting

confidence: 52%

The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?

et al. 2021

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“…and EASO center) at the Unit of Endocrinology, Clinical Medicine and Surgery Department, University “Federico II” of Naples. Some of the participants were also recruited during the OPERA prevention project [ 32 ]. This research was approved by Ethical Committee Federico II (n. 239/11) and was conducted following the Code of Ethics of the World Medical Association (Declaration of Helsinki) for human studies.…”

Section: Methodsmentioning

confidence: 99%

Phase Angle as an Easy Diagnostic Tool of Meta-Inflammation for the Nutritionist

et al. 2021

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Phase angle (PhA), a noninvasive bioimpedance marker, is a useful tool for nutritional screening in several diseases. C-reactive protein (CRP), a strong risk factor for metabolic and cardiovascular diseases, is a commonly used biomarker of meta-inflammation. As both PhA and CRP are influenced by age, BMI, and nutritional status, and exhibit a clear sex dimorphism, we examined the association between PhA and CRP levels in 1855 subjects (680 males and 1175 females), aged 18–59 years, with BMIs ranging from 19.5 to 69.4 kg/m2, stratified according to sex. PhA values and CRP levels were significantly lower in females than males (p < 0.001), while the adherence to the Mediterranean diet (MD) was lower in males compared to females (p < 0.001). After adjusting for age, physical activity, BMI, waist circumference, and adherence to the MD, PhA remained negatively associated with CRP levels in both genders (p < 0.001). In the ROC analysis, PhA ≤ 5.5° in males and ≤5.4° in females were the threshold values predicting increased hs-CRP levels. These results suggested that PhA might represent a valid predictor of CRP levels in both sexes regardless of body weight and adherence to the MD, which avoids the collection of blood sampling and expensive biochemical assays.

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“…Two hundred forty-seven Caucasian adult subjects aged between 20 and 68 years of both sexes were consecutively enrolled in the same urban area in Naples in Italy among patients of our clinic, volunteers, hospital employees, and participants in the Obesity, Programs of nutrition, Education, Research and Assessment of the best treatment (OPERA) project [ 22 ]. It was confirmed that all women were neither pregnant nor lactating.…”

Section: Methodsmentioning

confidence: 99%

Association of the Chronotype Score with Circulating Trimethylamine N-Oxide (TMAO) Concentrations

Barrea

Muscogiuri²,

Pugliese³

et al. 2021

Nutrients

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Individual differences in the chronotype, an attitude that best expresses the individual circadian preference in behavioral and biological rhythms, have been associated with cardiometabolic risk and gut dysbiosis. Up to now, there are no studies evaluating the association between chronotypes and circulating TMAO concentrations, a predictor of cardiometabolic risk and a useful marker of gut dysbiosis. In this study population (147 females and 100 males), subjects with the morning chronotype had the lowest BMI and waist circumference (p < 0.001), and a better metabolic profile compared to the other chronotypes. In addition, the morning chronotype had the highest adherence to the Mediterranean diet (p < 0.001) and the lowest circulating TMAO concentrations (p < 0.001). After adjusting for BMI and adherence to the Mediterranean diet, the correlation between circulating TMAO concentrations and chronotype score was still kept (r = −0.627, p < 0.001). Using a linear regression analysis, higher chronotype scores were mostly associated with lower circulating TMAO concentrations (β = −0.479, t = −12.08, and p < 0.001). Using a restricted cubic spline analysis, we found that a chronotype score ≥59 (p < 0.001, R2 = −0.824) demonstrated a more significant inverse linear relationship with circulating TMAO concentrations compared with knots <59 (neither chronotype) and <41 (evening chronotype). The current study reported the first evidence that higher circulating TMAO concentrations were associated with the evening chronotype that, in turn, is usually linked to an unhealthy lifestyle mostly characterized by low adherence to the MD.

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The opera prevention project

Cited by 25 publications

References 9 publications

The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?

The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?

Phase Angle as an Easy Diagnostic Tool of Meta-Inflammation for the Nutritionist

Association of the Chronotype Score with Circulating Trimethylamine N-Oxide (TMAO) Concentrations

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