The OpenFlexure Block Stage: sub-100 nm fibre alignment with a monolithic plastic flexure stage

Meng, Qingxin; Harrington, Kerrianne; Stirling, Julian; Bowman, Richard

doi:10.1364/oe.384207

Cited by 18 publications

(15 citation statements)

References 10 publications

(10 reference statements)

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“…The 3D-printing technique for the microfluidic mold comes with beneficial tools such as the rapid process and complex 3D creations with high height and high resolution, via a mask-free layer-by-layer fabrication . A variety of applications have been demonstrated because of the rapid and convenient assembly process through 3D-printed block assembly. − With regard to microfluidics, 3D-printed microfluidic molds provide an aligned channel due to the block assembly process. A microfluidic mold featuring alignment pillars was designed and printed with a valve switch alignment block, which was created for the alignment cavity of the valve switch arms.…”

Section: Resultsmentioning

confidence: 99%

Programmable DNA-Based Boolean Logic Microfluidic Processing Unit

Lee

Lim

et al. 2021

ACS Nano

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As molecular computing materials, information-encoded deoxyribonucleic acid (DNA) strands provide a logical computing process by cascaded and parallel chain reactions. However, the reactions in DNA-based combinational logic computing are mostly achieved through a manual process by adding desired DNA molecules in a single microtube or a substrate. For DNA-based Boolean logic, using microfluidic chips can afford automated operation, programmable control, and seamless combinational logic operation, similar to electronic microprocessors. In this paper, we present a programmable DNA-based microfluidic processing unit (MPU) chip that can be controlled via a personal computer for performing DNA calculations. To fabricate this DNA-based MPU, polydimethylsiloxane was cast using double-sided molding techniques for alignment between the microfluidics and valve switch. For a uniform surface, molds fabricated using a three-dimensional printer were spin-coated by a polymer. For programming control, the valve switch arms were operated by servo motors. In the MPU controlled via a personal computer or smartphone application, the molecules with two input DNAs and a logic template DNA were reacted for the basic AND and OR operations. Furthermore, the DNA molecules reacted in a cascading manner for combinational AND and OR operations. Finally, we demonstrated a 2-to-1 multiplexer and the XOR operation with a three-step cascade reaction using the simple DNA-based MPU, which can perform Boolean logic operations (AND, OR, and NOT). Through logic combination, this DNA-based Boolean logic MPU, which can be operated using programming language, is expected to facilitate the development of complex functional circuits such as arithmetic logical units and neuromorphic circuits.

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Section: Resultsmentioning

confidence: 99%

Programmable DNA-Based Boolean Logic Microfluidic Processing Unit

Lee

Lim

et al. 2021

ACS Nano

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“…Building on this kind of flexure, it is possible to 3D print a sub-100nm fiber alignment stage. [40] This is impressive if you think that the stage is a single block of 3D-printed plastic. Another recently developme 3D printable microscope is the PUMA.…”

Section: Phase 2: Designingmentioning

confidence: 99%

A 3D Printer in the lab: not only a toy

Saggiomo

2022

Preprint

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Although 3D printers are becoming more common in households, they are still underrepresented in many laboratories worldwide and regarded as toys rather than as laboratory equipment. This short review wants to change this conservative point of view. This mini-review focuses on Fused Deposition Modeling (FDM) printers and what happens after acquiring your first 3D printer. In short, these printers melt plastic filament and deposit it layer by layer to create the final object. They are getting cheaper and easier to use, and nowadays it is not difficult to find good 3D printers for less than 500€. At such a price, a 3D printer is one, if not the most, versatile piece of equipment you can have in a laboratory.

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“…Building on this kind of flexure, it is possible to 3D print a sub-100nm fiber alignment stage. [33] This is impressive if you think that the stage is a single block of 3D-printed plastic. The use of 3D printers has also opened the field to the fabrication of Do-It-Yourself microscopes, where various 3D printed optical blocks can be put together for different microscopy set-ups.…”

Section: Phase 2: Designingmentioning

confidence: 99%