The onset of daily torpor is regulated by the same low body mass in lean mice and in mice with diet-induced obesity

Solymár, Margit; Pétervári, Erika; Balaskó, Márta; Szelényi, Zoltán

doi:10.1080/23328940.2015.1014250

Cited by 16 publications

(11 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Respectively, the placebo and the E2 groups lowered T b to a minimum of~26.6°C and~31.5°C (Supplementary Table 2). CR affected body weight of both placebo and E2 groups in a similar manner; ruling out the possibility that the hypothermic prevention observed in the E2 group was due to mass differences between groups instead of the hormone replacement itself [21] (Figure 2(b)).…”

Section: -ß Estradiol Severely Reduced the Hypothermic Response To mentioning

confidence: 86%

Gonadal hormones influence core body temperature during calorie restriction

et al. 2019

View full text Add to dashboard Cite

During calorie restriction (CR), endotherms adjust several physiological processes including the decrease of core body temperature (T b ) and reduction of energy expenditure. We recently found that CR-induced hypothermia is regulated in a sex-dependent manner in mice with lowered central insulin-like growth factor receptor signaling. Here, we describe the contribution of sex hormones to CR-induced hypothermia in wild type C57BL6 mice by measuring T b of female and male mice following bilateral gonadectomy and hormonal replacement. Specifically, we evaluated the effects of progesterone (P4), 17-ß estradiol (E2), a combination of both (P4 + E2) in females and of 5-α dihydrotestosterone (5-α DHT) in males. Gonadectomy resulted in an earlier and stronger CR-induced hypothermia in both sexes. These effects were fully antagonized in females by E2 replacement, but not by P4, which had only minor and partial effects when used alone and did not prevent the action of E2 during CR when both hormones were given in combination. 5-α-DHT had only minor and transient effects on preventing the reduction of T b during CR on gonadectomized male mice. These findings indicate that gonadal hormones contribute to sex-specific regulation of T b and energy expenditure when nutrient availability is scarce.

show abstract

Section: -ß Estradiol Severely Reduced the Hypothermic Response To mentioning

confidence: 86%

Gonadal hormones influence core body temperature during calorie restriction

et al. 2019

View full text Add to dashboard Cite

show abstract

“…By contrast, HFDobese mice do not undergo torpor following an overnight fast (present study and ref. 26) but do go into a state of profound torpor after injection of pyruvate, an energy-rich substrate. Finally, pyruvate induces torpor in genetically obese db/db and ob/ ob mice, but, in contrast to DIO mice and like lean mice, these mice also enter torpor upon fasting (even more severe than in lean mice).…”

Section: Discussionmentioning

confidence: 99%

Pyruvate induces torpor in obese mice

Soto

Orliaguet

Reyzer

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Mice subjected to cold or caloric deprivation can reduce body temperature and metabolic rate and enter a state of torpor. Here we show that administration of pyruvate, an energy-rich metabolic intermediate, can induce torpor in mice with diet-induced or genetic obesity. This is associated with marked hypothermia, decreased activity, and decreased metabolic rate. The drop in body temperature correlates with the degree of obesity and is blunted by housing mice at thermoneutrality. Induction of torpor by pyruvate in obese mice relies on adenosine signaling and is accompanied by changes in brain levels of hexose bisphosphate and GABA as detected by mass spectroscopy-based imaging. Pyruvate does not induce torpor in lean mice but results in the activation of brown adipose tissue (BAT) with an increase in the level of uncoupling protein-1 (UCP1). Denervation of BAT in lean mice blocks this increase in UCP1 and allows the pyruvate-induced torpor phenotype. Thus, pyruvate administration induces torpor in obese mice by pathways involving adenosine and GABA signaling and a failure of normal activation of BAT.

show abstract

“…That is what Solymár et al. 1 have investigated, for the first time. In the face of a complete fast, mice previously made obese did not enter torpor until their body mass approached that of the normal-mass mice, a process that took several weeks; the obese mice started with a body mass more than double that of the control lean mice Figure.…”

mentioning

confidence: 52%

“…I thank the editors of Temperature for the opportunity to provide an editorial comment on the recent article by Solymár et al. 1 We have known for some time that, when endothermic animals are fasted, their energy expenditure pathways are altered in a way that results in a decrease in core body temperature during the inactive phase of their daily activity cycle. 2 The decrease in body temperature generally is viewed as adaptive, since the closer the animal's body temperature is to ambient temperature, the less energy is required to defend body temperature.…”

mentioning

confidence: 99%

Energy signaling in obese mice delays the impact of fasting on thermoregulation

Maloney

2016

Temperature

View full text Add to dashboard Cite

The onset of daily torpor is regulated by the same low body mass in lean mice and in mice with diet-induced obesity

Cited by 16 publications

References 33 publications

Gonadal hormones influence core body temperature during calorie restriction

Gonadal hormones influence core body temperature during calorie restriction

Pyruvate induces torpor in obese mice

Energy signaling in obese mice delays the impact of fasting on thermoregulation

Contact Info

Product

Resources

About