“…Because it has been shown that gluconeogenesis is activated in liver of fasted obese human, ob / ob mice, and high-fat diet-fed mice ( Turner et al., 2005 ; Basu et al., 2005 ; Satapati et al., 2012 ), gluconeogenesis is likely to be relatively more dominant than glycolysis in liver of fasted ob / ob mice. Besides, it has been reported to increase the blood glucose level in fasted db / db mice, a leptin receptor-deficient mice ( Clementi et al., 2011 ; Liu et al., 2012 ), and high-fat diet-fed mice more than in wild-type mice and standard-chow-diet-fed mice ( Soto et al., 2018 ), respectively, by intraperitoneal pyruvate administration. These results also support our interpretation that gluconeogenesis is more dominant than glycolysis.…”