The ongoing problem with peripheral lymphadenopathies: which ones are malignant?

Karaman, Ayşe; Karaman, Íbrahím; Çavuşoğlu, Yusuf Hakan; Erdoğan, Derya

doi:10.1007/s00383-009-2498-4

Cited by 12 publications

(23 citation statements)

References 7 publications

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“…LAP > 2 cm in size are suspicious for malignancies or granulomatous diseases and LAP < 1 cm in size suggest benign diseases 5,7,9 . Karaman et al reported that there is no significant difference between benign and malignant diseases with respect to LAP size similar to our findings 10 . On the other hand Kumral et al reported that LAP larger than 3 cm represent a greater risks for malignancies 5 .…”

Section: Discussionsupporting

confidence: 82%

“…Histopathologic examination showed granulomatous diseases in 10 patients (20%) and it was consistent with reactive lymphoid hyperplasia in 8 patients (16%). The malignancy rates in patients with persistent LAP were 30.0%, 27.0%, and 38.0% in studies conducted by Kumral et al , Karadeniz et al and Karaman et al respectively 5,9,10 . Excisional biopsy should be considered with LAP hard or matted, fixed to the surrounding tissue, increasing rapidly in size, unresponsive to antibiotic therapy over 4-8 weeks, localized cervical or supraclavicular region, presence of organomegali and mediastinel LAP, associated symptoms like fever of unknown origin, night sweeats, weight loss or difficulty in diagnosis [2][3][4][5]8,20 .…”

Section: Discussionmentioning

confidence: 99%

“…Age is an important factor in differentiating between benign and malignant LAP in childeren. The rate of malignant etiologies of peripheral LAP is low in children, but increases with age [8][9][10] . Soldes et al reported the risk of malignancy in peripheral LAP increases with the age of child, size of LAP and the number of involved sites 11 .…”

Section: Discussionmentioning

confidence: 99%

“…In the current study, the incidences of anemia, thrombocytopenia and leucopenia were significant in the malignant LAP group, but the white blood cell counts were not a diagnostic criterion. The peripheral smear constitutes the first step in the evaluation of patients with LAP 10 . An elevated ESR and CRP, also known as acute phase reactants, did not reveal any clinical significance in the differential diagnosis of patients with malignant LAP 5,7 .…”

Section: Discussionmentioning

confidence: 99%

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Çocukluk Çağında Periferik Lenfadenopatiler: Tek Merkezli Çalışma

Özkale¹,

Özkale²,

Sipahi³

2015

Cukurova Medical Journal

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Cukurova Medical Journal 2015;40(3):418-429. ABSTRACTSPurpose: Lymphadenopathy is defined as an abnormality in the size and/or character of lymph node. In this study we aimed to describe the clinical and laboratory findings of benign and malignant causes of peripheral lymphadenopathy in childhood. Material and Methods: Two hundred and twenty four patients who were admitted to the clinic with peripheral LAP were evaluated. Age, gender, laboratory and radiologic findings, final diagnoses, and duration, localization, size, consistency, spread, and accompanying local and systemic symptoms of LAP were determined. Benign and malignant causes of peripheral lymphadenopathy were compared. Results: One hundred twenty-six patients (56.0%) were male and 98 patients (44.0%) were female. After the first evaluation the patients were divided into two groups. The first group included 186 patients with benign causes and the second group included 38 patients with malignant causes. One hundred and sixty four of 224 patients (73.2 %) had localized peripheral lymphadenopathy. The most frequent cause of localized lymphadenopathy in the benign group was acute lymphadenitis (34.8%). The most common cause of localized lymphadenopathy in the malignant group was Hodgkin's lymphoma (4.3%). Sixty of 224 (26.8%) patients had generalized peripheral lymphadenopathy. The most significant cause of generalized lymphadenopathy in the benign lymphadenopathy group was Epstein-Barr virus (10.0%), whereas Hodgkin's lymphoma (23.3%) was the most common cause in malign lymphadenopathy group. Localized and generalized lymph node enlargement was most frequently found in cervical region. The most frequent site of involvement among benign and malignant cases was the cervical area. The results revealed that findings such as chronic course, generalized LAP, supraclavicular, cervical and inguinal location, organomegaly, hilier LAP, abdominal LAP, and abnormal laboratory findings (thrombocytopenia and blasts on the peripheral blood smear) were associated with malignant diseases. Araştırma Makalesi / Research Article

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Çocukluk Çağında Periferik Lenfadenopatiler: Tek Merkezli Çalışma

Özkale¹,

Özkale²,

Sipahi³

2015

Cukurova Medical Journal

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“…Matsumoto et al [14] performed cervical lymph node biopsy on 60 non-cancer patients and found that serum levels of lactate dehydrogenase, interleukin 2 receptor levels, age and lymph node size in the malignant lymphoma group were significantly higher than in the benign group. In another retrospective study including 84 children who underwent surgical lymph node excision, increasing age, shorter duration of lymphadenopathy, larger size, and supraclavicular location were found to be associated with malignancy [15]. Soldes et al [16] performed lymph node biopsies in 60 consecutive patients aged 18 years or below and found that risk of malignancy is correlated with increasing size, age, and number of involved sites.…”

Section: Discussionmentioning

confidence: 97%

Predictive factors for malignancy in patients with persistent cervical lymphadenopathy

Çelenk

Gülşen

Baysal

et al. 2015

Eur Arch Otorhinolaryngol

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The aim of this study was to identify clinical factors that can predict malignancy in patients with persistent cervical lymphadenopathy. This retrospective study included 575 patients with persistent cervical lymphadenopathy who underwent surgical excision. The patients were divided into two groups according to their ages: group 1 (≤18 years) and group 2 (>18 years). Multiple logistic regression models and univariate analysis were performed to determine the association between clinical factors and malignancy. Male gender [odds ratio (OR) 4.184, 95 % confidence interval (CI) 1.823-9.602, p = 0.001], increased age (OR 1.072, 95 % CI 1.001-1.148, p = 0.046), left-sided lesions (OR 3.423, 95 % CI 1.407-8.329, p = 0.007), and larger lymph node size (OR 1.445, 95 % CI 1.021-2.044, p = 0.038) were significantly associated with malignancy in group 1. Male gender (OR 3.761, 95 % CI 2.361-5.992, p = 0.001), increased age (OR 1.015, 95 % CI 1.003-1.027, p = 0.018), duration of the disease (OR 0.770, 95 % CI 0.668-0.888, p = 0.001), and the presence of B symptoms (OR 4.996, 95 % CI 2.862-8.721, p = 0.001) were significantly associated with malignancy in group 2. The sensitivity and specificity of the models were 84 and 61.5 % for group 1 and 77.9 and 67.9 % for group 2, respectively. Increasing age and male gender were found to be associated with malignancy in all age groups. Larger lymph node size and left-sided lymphadenopathy were significant predictors of malignancy in children. Presence of B symptoms was found to be associated with malignancy in adults. Our results indicated that increasing duration of lymphadenopathy and the presence of bilaterality render the lymph node more likely to be benign in adults. No significant association was found between the involved neck site and malignancy for all age groups.

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