Çocukluk Çağında Periferik Lenfadenopatiler: Tek Merkezli Çalışma

Abstract

Cukurova Medical Journal 2015;40(3):418-429. ABSTRACTSPurpose: Lymphadenopathy is defined as an abnormality in the size and/or character of lymph node. In this study we aimed to describe the clinical and laboratory findings of benign and malignant causes of peripheral lymphadenopathy in childhood. Material and Methods: Two hundred and twenty four patients who were admitted to the clinic with peripheral LAP were evaluated. Age, gender, laboratory and radiologic findings, final diagnoses, and duration, localization, size, consistency, spread, and accompanying local and systemic symptoms of LAP were determined. Benign and malignant causes of peripheral lymphadenopathy were compared. Results: One hundred twenty-six patients (56.0%) were male and 98 patients (44.0%) were female. After the first evaluation the patients were divided into two groups. The first group included 186 patients with benign causes and the second group included 38 patients with malignant causes. One hundred and sixty four of 224 patients (73.2 %) had localized peripheral lymphadenopathy. The most frequent cause of localized lymphadenopathy in the benign group was acute lymphadenitis (34.8%). The most common cause of localized lymphadenopathy in the malignant group was Hodgkin's lymphoma (4.3%). Sixty of 224 (26.8%) patients had generalized peripheral lymphadenopathy. The most significant cause of generalized lymphadenopathy in the benign lymphadenopathy group was Epstein-Barr virus (10.0%), whereas Hodgkin's lymphoma (23.3%) was the most common cause in malign lymphadenopathy group. Localized and generalized lymph node enlargement was most frequently found in cervical region. The most frequent site of involvement among benign and malignant cases was the cervical area. The results revealed that findings such as chronic course, generalized LAP, supraclavicular, cervical and inguinal location, organomegaly, hilier LAP, abdominal LAP, and abnormal laboratory findings (thrombocytopenia and blasts on the peripheral blood smear) were associated with malignant diseases. Araştırma Makalesi / Research Article

Association Between Clinical, Laboratory, and Ultrasound Characteristics and Cancer Incidence of Peripheral Lymphadenopathy in Children

“…Various studies in the literature reported that lymphadenopathy was more common in the male gender (31). In a study, the mean age of these patients was reported to be 7.4±4.7 years (31). The findings regarding age and gender in our study are compatible with the literature.…”

“…In a study of children under the age of five, lymph nodes were found in 44% of healthy children and 64% of children evaluated for disease (30). Various studies in the literature reported that lymphadenopathy was more common in the male gender (31). In a study, the mean age of these patients was reported to be 7.4±4.7 years (31).…”

Clinical Caharacteristics Of And Cancer Incidence In Children Evaluated For Lymphadenoapthy Referred To Pediatrci Oncology Clinics

“…[13] In studies conducted in children of our country, the cancer rate has been reported in a wide range, such as 1-38%. [14][15][16][17][18][19][20][21] Incidence rates of cancer reported from pediatric oncology outpatient clinics range most prevalently between 1, and 38 percent. [14][15][16][17][18][19][20][21] The highest rates (>15%) have been generally reported in studies conducted in pediatric oncology polyclinics.…”

“…[14][15][16][17][18][19][20][21] Incidence rates of cancer reported from pediatric oncology outpatient clinics range most prevalently between 1, and 38 percent. [14][15][16][17][18][19][20][21] The highest rates (>15%) have been generally reported in studies conducted in pediatric oncology polyclinics. [14][15][16][17][18][19][20][21] In a study reporting only the results of patients undergoing biopsy, the rate of cancer reportedly increased up to 40.8%.…”

“…[14][15][16][17][18][19][20][21] The highest rates (>15%) have been generally reported in studies conducted in pediatric oncology polyclinics. [14][15][16][17][18][19][20][21] In a study reporting only the results of patients undergoing biopsy, the rate of cancer reportedly increased up to 40.8%. [22] In a study in our country, contrary to what is expected, only one of 98 patients who were sent to the pediatric oncology center was diagnosed with Hodgkin lymphoma.…”