The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV)

Micol, Vicente; Caturla, Nuria; Pérez-Fons, Laura; Más, Vicente; Pérez, Luis; Estepa, A.

doi:10.1016/j.antiviral.2005.02.005

Cited by 231 publications

(129 citation statements)

References 35 publications

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“…Oleuropein, the major polyphenolic constituent of olive oil, is another structurally different phenolic compound. [7] All these compounds have demonstrated a host of biological activities, displaying excellent antioxidant, [8,9] antitumor, [10,11] antiviral, [12] antimicrobial, [13] and anti-atherogenic [14,15] properties.…”

Section: Introductionmentioning

confidence: 99%

Combining Computational and Biochemical Studies for a Rationale on the Anti‐Aromatase Activity of Natural Polyphenols

et al. 2007

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Aromatase, an enzyme of the cytochrome P450 family, is a very important pharmacological target, particularly for the treatment of breast cancer. The anti‐aromatase activity of a set of natural polyphenolic compounds was evaluated in vitro. Strong aromatase inhibitors including flavones, flavanones, resveratrol, and oleuropein, with activities comparable to that of the reference anti‐aromatase drug aminoglutethimide, were identified. Through the application of molecular modeling techniques based on grid‐independent descriptors and molecular interaction fields, the major physicochemical features associated with inhibitory activity were disclosed, and a putative virtual active site of aromatase was proposed. Docking of the inhibitors into a 3D homology model structure of the enzyme defined a common binding mode for the small molecules under investigation. The good correlation between computational and biological results provides the first rationalization of the anti‐aromatase activity of polyphenolic compounds. Moreover, the information generated in this approach should be further exploited for the design of new aromatase inhibitors.

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Section: Introductionmentioning

confidence: 99%

Combining Computational and Biochemical Studies for a Rationale on the Anti‐Aromatase Activity of Natural Polyphenols

et al. 2007

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“…All plant organs contain flavonoids; however, their quantity varies depending on the plant species or ecological and genetic factors [10][11][12][13][14][15]. Bioactive compounds isolated from O. europaea leaves have antiviral, antimicrobial, antioxidant, anticancer, anti-inflammatory and hypoglycaemic properties [16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Ecological variability of the phenolic compounds of Olea europaea L. leaves from natural habitats and cultivated conditions

Stanković

Ćurčić

Zlatić

et al. 2017

Biotechnology & Biotechnological Equipment

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Many compounds from the phenolic group, flavonoids in particular, are well-known antioxidants, although their role in plant response to stress is debatable. The aim of this study was to determine the variability of the phenolic content and the antioxidant activity of Olea europaea leaf samples from different habitats. The determination included measurement of the total quantity of phenolics, the flavonoid content, as well as the antioxidant activity of the two types of methanolic leaf extracts of O. europaea from several natural habitats in the Mediterranean region (Tunisia, Malta and Montenegro) and from cultivated conditions (France and Serbia). The results showed that both the total quantity of phenols and flavonoids as well as the intensity of antioxidant activity in the two types of extracts largely depended on the type of habitat. The total quantity of phenols and flavonoids was greater in the samples from cultivated plants which demonstrated the significance of certain conditions in terms of the correlation between the intensity of primary and secondary metabolism. However, the values of antioxidant activity in both types of extract were higher in the samples from natural habitats. The results showed that plants from natural habitats contain secondary metabolites with high biological activity. It could be speculated that these active substances play an important role in the adaptation of plants to the stress caused by arid conditions.

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“…For example, antiviral activities of many phytochemicals have been described for vesicular stomatitis virus (VSV) (Chiba et al, 1992;Eo et al, 1999Eo et al, , 2001. Similarly, gall extract from Guiera senegalensis J. F. Gmel (Combretaceae) inhibits fowlpox virus-(FPV) (Lamien et al, 2005a,b), olive leaf extract inhibits hemorrhagic septicemia rhabdovirus-(VHSV) (Micol et al, 2005), and the extract of Dunbaria bella Prain (Fabaceae) and Euphorbia thymifolia have been found to be active against herpes viruses (Yang et al, 2005;Akanitapichat et al, 2006). Babul is one of the popular medicinal plants in India and is widely used as an ethno-veterinary therapeutic agent.…”

Section: Resultsmentioning

confidence: 99%

Potential Effect ofAcacia arabica. onPeste des Petits Ruminants. Virus Replication

Balamurugan

Saravanan

Bhanuprakash

et al. 2008

Pharmaceutical Biology

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The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV)

Cited by 231 publications

References 35 publications

Combining Computational and Biochemical Studies for a Rationale on the Anti‐Aromatase Activity of Natural Polyphenols

Combining Computational and Biochemical Studies for a Rationale on the Anti‐Aromatase Activity of Natural Polyphenols

Ecological variability of the phenolic compounds of Olea europaea L. leaves from natural habitats and cultivated conditions

Potential Effect ofAcacia arabica. onPeste des Petits Ruminants. Virus Replication

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