The olfactory neuroepithelial tumorsA review of the literature and report of six additional cases

Mendeloff, Joseph

doi:10.1002/1097-0142(195709/10)10:5<944::aid-cncr2820100513>3.0.co;2-g

Cited by 72 publications

(11 citation statements)

References 4 publications

(1 reference statement)

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“…I I . 14.49.53.54.56.58-61 cranial extension, 14.15.47,56.58.59.62-67 207 metastases, 11,14,49,53.56,58-61,67 187 1. Neuroblastomas with olfactory differentiation have a high incidence of metastases.…”

Section: Absentmentioning

confidence: 99%

Neuroblastomas and neuroendocrine carcinomas of the nasal cavity. A proposed new classification

Silva

Butler

Mackay

et al. 1982

Cancer

184

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The histologic characteristics of 29 nasal tumors previously diagnosed as neuroblastomas, unclassified carcinomas, or unclassified malignant neoplasms were reviewed. Electron microscopy was performed in 17. Nine tumors were neuroblastomas; six of these were classical neuroblastomas while the other three exhibited olfactory differentiation in addition to the classical neuroblastoma component. Areas of ganglioneuroblastoma were found in the metastasis of one of the three olfactory neuroblastomas. Twenty tumors were classified as neuroendocrine carcinoma because all showed a neuroendocrine pattern with remarkably uniform cells growing from benign glandular epithelium; membrane bound granules were present in the cytoplasm of cells of the ten cases in this group examined by electron microscopy. The mean age of the patients with neuroblastomas was 20 years; survival in this group was 75% at five and seven years, respectively, and 67% at ten years. Recurrences, metastasis, and death occurred within 3 years of diagnosis. There was a low percentage (25%) of multiple recurrences. The metastases were located in cervical lymph nodes, brain and spine. The mean age of the patients with neuroendocrine carcinoma was 50 years. Survival was 100% at five years, 88% at seven years, and 77% at ten years. Recurrences and metastasis in 70% of the cases occurred later than the third year. Multiple recurrences were present in 54% of the cases. The metastases affected lymph nodes, brain and spine in all cases except in one in which lungs and femur were involved. In the latter case adenocarcinoma was also present in addition to the neuroendocrine carcinoma. Three patients died, all more than five years from the time of diagnosis. No correlation was found between staging and prognosis in either group, except for Stage I disease.

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Section: Absentmentioning

confidence: 99%

Neuroblastomas and neuroendocrine carcinomas of the nasal cavity. A proposed new classification

Silva

Butler

Mackay

et al. 1982

Cancer

184

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“…Squamous cell carcinoma can be seldom observed in wounds of the postoperative maxillary sinus because removal of the maxillary mucosa membranes by Caldwell-Luc's method eliminates the place where squamous cell carcinoma arises. Silva 2 and Mendeloff 4 suggested olfactory epithelium as the original cell of neuroendocrine carcinoma, Schall 5 reported spheno-palatine nerve. A main aggressive finding in this case showed destructions of the posterior bone wall in the maxillary sinus.…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine Carcinoma Arising in a Wound of the Postoperative Maxillary Sinus

Kusunoki¹,

Ikeda²

2012

Clinics and Practice

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We report a case of a neuroendocrine carcinoma arising in a wound of the postoperative maxillary sinus that was difficult to distinguish from a postoperative maxillary cyst. The patient was a 65-year-old Japanese woman who complained of left exophthalmos with cheek swelling and eye movement disorders. In past history, she had, 40 years previously undergone operation on the bilateral maxillary sinus by Caldwell-Luc's method. In a preoperative computed tomography, a mass occupied the left maxillary sinus showing irregular densities with destruction of the posterior bone walls and invasion into the left orbital. Both TI and T2 weighted magnetic resonance imaging showed low intensities and unevenness in the mass. We performed a biopsy of the maxillary tumor according to Caldwell-Luc's method. Histological examination diagnosed neuroendocrine carcinoma. Radiation therapy (total 66Gy) resulted in partial response for this tumor. However, sinonasal neuroendocrine carcinoma has been identified as highly aggressive, with a high probability of recurrence and metastasis.

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“…However, cases do occur in childrea Seaman (1951) was the first to report a case in an eight-year-old female and he subsequently reported three other cases in children aged between 13 and 14 years. Mendeloff (1957) reviewed the literature and reported that the age-range of patients with olfactory neuroblastoma was between eight to 79 years. Olfactory neuroblastoma occurs with equal frequency in males and females.…”

Section: Discussionmentioning

confidence: 99%

“…Olfactory neuroblastoma occurs with equal frequency in males and females. The 28 cases reported by Mendeloff (1957) were equally distributed between the sexes.…”

Section: Discussionmentioning

confidence: 99%

Olfactory neuroblastoma: A case report in an African child

et al. 1983

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SummaryThe case is described of an eight-year-old Nigerian boy who died from olfactory neuroblastoma which presented with nasal obstruction and epistaxis. Autopsy showed intracranial extension of the tumour into the frontal lobe, and histology revealed undifferentiated neuroblasts, forming rosette in some areas and producing tangled neurofibrils in others. The histogenesis of the tumour and its diagnosis are briefly discussed.

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The olfactory neuroepithelial tumorsA review of the literature and report of six additional cases

Cited by 72 publications

References 4 publications

Neuroblastomas and neuroendocrine carcinomas of the nasal cavity. A proposed new classification

Neuroblastomas and neuroendocrine carcinomas of the nasal cavity. A proposed new classification

Neuroendocrine Carcinoma Arising in a Wound of the Postoperative Maxillary Sinus

Olfactory neuroblastoma: A case report in an African child

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