1982
DOI: 10.1002/1097-0142(19821201)50:11<2388::aid-cncr2820501126>3.0.co;2-k
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Neuroblastomas and neuroendocrine carcinomas of the nasal cavity. A proposed new classification

Abstract: The histologic characteristics of 29 nasal tumors previously diagnosed as neuroblastomas, unclassified carcinomas, or unclassified malignant neoplasms were reviewed. Electron microscopy was performed in 17. Nine tumors were neuroblastomas; six of these were classical neuroblastomas while the other three exhibited olfactory differentiation in addition to the classical neuroblastoma component. Areas of ganglioneuroblastoma were found in the metastasis of one of the three olfactory neuroblastomas. Twenty tumors w… Show more

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Cited by 184 publications
(110 citation statements)
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“…These were supplemented by another 19 relevant publications found in references cited. 4,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] The studies were divided into three types, according to their principal objectives: origin and aetiology of ENB, 9,11,15,[17][18][19]21,24,[27][28][29][30][31][32][33][34][35][36][37][38][39][40] histopathological diagnosis; 10,[12][13][14]23,37,[41][42][43][44]…”
Section: Search Strategy and Selection Criteriamentioning
confidence: 99%
See 1 more Smart Citation
“…These were supplemented by another 19 relevant publications found in references cited. 4,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] The studies were divided into three types, according to their principal objectives: origin and aetiology of ENB, 9,11,15,[17][18][19]21,24,[27][28][29][30][31][32][33][34][35][36][37][38][39][40] histopathological diagnosis; 10,[12][13][14]23,37,[41][42][43][44]…”
Section: Search Strategy and Selection Criteriamentioning
confidence: 99%
“…23 Another aggressive neoplasm that must be distinguished from ENB is neuroendocrine sinonasal carcinoma, as originally suggested by Silva and colleagues. 10 Cytokeratin immunopositivity, especially in a punctate paranuclear distribution is the main diagnostic marker for differentiation from ENB. 51 Electron microscopy may be useful in demonstrating junctional complexes and tonofilaments.…”
Section: Histopathological Diagnosismentioning
confidence: 99%
“…These cells contain membrane bound granules in the cytoplasm which can be demonstrated by Grimelius stain [4], electron microscopy [6] and their endocrine differentiation can be demonstrated by immunohistochemistry [4,7]. The tumour cells originate from the basal cells in the olfactory mucosa [8].…”
Section: Discussionmentioning
confidence: 99%
“…For staging of neuroendocrine tumours of sinonasal tract, the Kadish staging system is often used [8]. Accordingly the tumours are reported as stage-A (tumours limited to nasal cavity), stage-B (tumours localized in the nasal cavity and paranasal sinuses) and stage-C (tumours extending beyond nasal cavity and paranasal sinuses).…”
Section: Discussionmentioning
confidence: 99%
“…The development of a clinically meaningful and pathologically reproducible classification of NSNECs has been precluded by their rarity and confusion with other neoplasms such as ONB [9]. In its 2005 Classification of Head and Neck Tumors, the WHO categorized these neoplasms as ''typical carcinoid tumor'', ''atypical carcinoid tumor'', and neuroendocrine carcinoma ''not otherwise specified'' [1].…”
Section: Discussionmentioning
confidence: 99%