The Older Finnish Twin Cohort — 45 Years of Follow-up

Kaprio, Jaakko; Bollepalli, Sailalitha; Buchwald, Jadwiga; Iso‐Markku, Paula; Korhonen, Tellervo; Kovanen, Vuokko; Kujala, Urho M.; Laakkonen, Eija K.; Latvala, Antti; Leskinen, Tuija; Lindgrén, Noora; Ollikainen, Miina; Piirtola, Maarit; Rantanen, Taina; Rinne, Juha O.; Rose, Richard J.; Sillanpää, Elina; Silventoinen, Karri; Sipilä, Sarianna; Viljanen, Anne; Vuoksimaa, Eero; Waller, Katja

doi:10.1017/thg.2019.54

Cited by 85 publications

(102 citation statements)

References 111 publications

(130 reference statements)

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“…Data on participants from three FTC (Old twin cohort, Finntwin16, and Finntwin12) (15,16) were included in this study (N = 11,528 for both genetic and self-reported PA data; mean age, 44 yr (range, 18-93 yr); 46% male participants). From a subgroup of the Old twin cohort, 765 individuals had both genetic and objectively measured PA data (MOBILETWIN study; mean age, 73 yr (range, 71-75 yr); 46% male participants) (17).…”

Section: Methodsmentioning

confidence: 99%

Polygenic Risk Scores and Physical Activity

Palviainen

Pesonen

Waller

et al. 2020

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose: Polygenic risk scores (PRS) summarize genome-wide genotype data into a single variable that produces an individual-level risk score for genetic liability. PRS has been used for prediction of chronic diseases and some risk factors. As PRS has been studied less for physical activity (PA), we constructed PRS for PA and studied how much variation in PA can be explained by this PRS in independent population samples. Methods: We calculated PRS for self-reported and objectively measured PA using UK Biobank genome-wide association study summary statistics, and analyzed how much of the variation in selfreported (MET-hours per day) and measured (steps and moderate-to-vigorous PA minutes per day) PA could be accounted for by the PRS in the Finnish Twin Cohorts (FTC; N = 759-11,528) and the Northern Finland Birth Cohort 1966 (NFBC1966; N = 3263-4061). Objective measurement of PA was done with wrist-worn accelerometer in UK Biobank and NFBC1966 studies, and with hip-worn accelerometer in the FTC. Results: The PRS accounted from 0.07% to 1.44% of the variation (R 2) in the self-reported and objectively measured PA volumes (P value range = 0.023 to <0.0001) in the FTC and NFBC1966. For both self-reported and objectively measured PA, individuals in the highest PRS deciles had significantly (11%-28%) higher PA volumes compared with the lowest PRS deciles (P value range = 0.017 to <0.0001). Conclusions: PA is a multifactorial phenotype, and the PRS constructed based on UK Biobank results accounted for statistically significant but overall small proportion of the variation in PA in the Finnish cohorts. Using identical methods to assess PA and including less common and rare variants in the construction of PRS may increase the proportion of PA explained by the PRS.

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Section: Methodsmentioning

confidence: 99%

Polygenic Risk Scores and Physical Activity

Palviainen

Pesonen

Waller

et al. 2020

Medicine &Amp; Science in Sports &Amp; Exercise

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“…The Older Finnish Twin Cohort includes twins born in Finland before 1958 where both twins in a pair are alive in 1975 [18,19]. As these pairs of the same gender were selected from the Central Population Registry of Finland in 1974, the Cohort is population-based and its overall mortality and cancer incidence does not differ from that of the general population [18,20].…”

Section: Population Samplementioning

confidence: 99%

Changes in self-reported sleep duration with age - a 36-year longitudinal study of Finnish adults

2020

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Background Sleep deprivation is often claimed to be increasingly common, but most studies show small changes in sleep duration over the last decades. Our aim was to analyze long-term patterns in self-reported sleep duration in a population-based cohort. Methods Members of the Older Finnish Twin Cohort have responded to questionnaires in 1975 (N = 30,915 individuals, response rate 89%, mean age 36 years), 1981 (24,535, 84%, 41 years), 1990 (12,450, 77%, 44 years), and 2011 (8334, 72%, 60 years). Weibull regression models were used to model the effects of follow-up time and age simultaneously. Results Sleep duration has decreased in all adult age groups and in both genders. The mean duration was in men 7.57 h in 1975 and 7.39 in 2011, and in women 7.69 and 7.37, respectively. The decrease was about 0.5 min in men and 0.9 in women per year of follow-up. In the age-group 18–34 years, mean sleep length was 7.69 h in 1975 and 7.53 in 1990. Among 35–54-year-old it was 7.57 h in 1975 and 7.34 in 2011, and in the age group of 55+ year olds 7.52 and 7.38, correspondingly. The change was largest in middle-aged group: about 23 min or about 0.6 min per year of follow-up. Conclusions There has been a slight decrease in mean sleep duration during the 36-year follow-up. Although the sleep duration was longer in 1970s and 1980s, the probable main cause for the change in this study population is the effect of aging.

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“…National Institute for Health and Welfare Biobank for those participants with biosamples, please see Kaprio et al (2019) for our review paper on the older Finnish Twin Cohort.…”

Section: Methodsmentioning

confidence: 99%

FinnTwin12 Cohort: An Updated Review

et al. 2019

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This review offers an update on research conducted with FinnTwin12 (FT12), the youngest of the three Finnish Twin Cohorts. FT12 was designed as a two-stage study. In the first stage, we conducted multiwave questionnaire research enrolling all eligible twins born in Finland during 1983–1987 along with their biological parents. In stage 2, we intensively studied a subset of these twins with in-school assessments at age 12 and semistructured poly-diagnostic interviews at age 14. At baseline, parents of intensively studied twins were administered the adult version of the interview. Laboratory studies with repeat interviews, neuropsychological tests, and collection of DNA were made of intensively studied twins during follow-up in early adulthood. The basic aim of the FT12 study design was to obtain information on individual, familial and school/neighborhood risks for substance use/abuse prior to the onset of regular tobacco and alcohol use and then track trajectories of use and abuse and their consequences into adulthood. But the longitudinal assessments were not narrowly limited to this basic aim, and with multiwave, multirater assessments from ages 11 to 12, the study has created a richly informative data set for analyses of gene–environment interactions of both candidate genes and genomewide measures with measured risk-relevant environments. Because 25 years have elapsed since the start of the study, we are planning a fifth-wave follow-up assessment.

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The Older Finnish Twin Cohort — 45 Years of Follow-up

Cited by 85 publications

References 111 publications

Polygenic Risk Scores and Physical Activity

Polygenic Risk Scores and Physical Activity

Changes in self-reported sleep duration with age - a 36-year longitudinal study of Finnish adults

FinnTwin12 Cohort: An Updated Review

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