The offspring of the diabetic mother – Short- and long-term implications

Mitanchez, Delphine; Yzydorczyk, Catherine; Siddeek, Bénazir; Boubred, Farid; Benahmed, Mohamed; Simeoni, Umberto

doi:10.1016/j.bpobgyn.2014.08.004

Cited by 161 publications

(124 citation statements)

References 96 publications

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“…GDM is associated with a higher incidence of maternal morbidity including cesarean deliveries, shoulder dystocia, birth trauma, hypertensive disorders of pregnancy (including preeclampsia), and subsequent development of type 2 diabetes [299,300]. Perinatal and neonatal morbidities also increase; the latter include macrosomia, birth injury, hypoglycemia, polycythemia, and hyperbilirubinemia [299,300]. Exposure to hyperglycemia in early pregnancy has also been associated with IUGR [300].…”

Section: Consensus Recommendationsmentioning

confidence: 99%

The Impact of Kidney Development on the Life Course: A Consensus Document for Action

Brenner

Charlton

Luyckx

et al. 2017

Nephron

115

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Hypertension and chronic kidney disease (CKD) have a significant impact on global morbidity and mortality. The Low Birth Weight and Nephron Number Working Group has prepared a consensus document aimed to address the relatively neglected issue for the developmental programming of hypertension and CKD. It emerged from a workshop held on April 2, 2016, including eminent internationally recognized experts in the field of obstetrics, neonatology, and nephrology. Through multidisciplinary engagement, the goal of the workshop was to highlight the association between fetal and childhood development and an increased risk of adult diseases, focusing on hypertension and CKD, and to suggest possible practical solutions for the future. The recommendations for action of the consensus workshop are the results of combined clinical experience, shared research expertise, and a review of the literature. They highlight the need to act early to prevent CKD and other related noncommunicable diseases later in life by reducing low birth weight, small for gestational age, prematurity, and low nephron numbers at birth through coordinated interventions. Meeting the current unmet needs would help to define the most cost-effective strategies and to optimize interventions to limit or interrupt the developmental programming cycle of CKD later in life, especially in the poorest part of the world.

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Section: Consensus Recommendationsmentioning

confidence: 99%

The Impact of Kidney Development on the Life Course: A Consensus Document for Action

Brenner

Charlton

Luyckx

et al. 2017

Nephron

115

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“…Los recién nacidos de madres diabéticas tiene mayor riesgo de desarrollar síndrome de dificultad respiratoria como resultado del hiperinsulinismo fetal que altera la síntesis de surfactante pulmonar incluso después de las 34 semanas de gestación (7). En un estudio realizado por Moore (8), en el que se incluyeron 295 pacientes diabéticas y 590 controles, se encontró que en las pacientes diabéticas la maduración pulmonar fetal está retrasada entre 1 y 1,5 semanas.…”

Section: Discussionunclassified

Desenlaces maternos, fetales y perinatales de las gestantes con diabetes en manejo con bomba de insulina en el Hospital Universitario San Ignacio

et al. 2016

Rev. chil. obstet. ginecol.

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“…31 In the HAPO study, there was a weak association between hyperbilirubinemia and maternal blood glucose levels on the OGTT, 10 but the risk of severe hyperbilirubinemia, such as seen in hemolysis, is low. 23 …”

Section: Premature Birthmentioning

confidence: 99%

“…22 The risks to the fetus and newborn arising from maternal GDM are related to both macrosomia and to other proposed pathophysiological effects of fetal hyperglycemia and hyperinsulinism. [23][24][25] intrauterine fetal death and perinatal asphyxia Increased fetal substrate uptake arising from chronic fetal hyperinsulinism increases tissue oxygen consumption. This gives rise to relative fetal hypoxia, which increases the risk of intrauterine fetal death, 26 although the risk of this is less compared to that in maternal type 1 and 2 diabetes mellitus (DM), 26 and it has been argued that the reported increased risk may be in fact be attributable to undiagnosed type 2 DM.…”

mentioning

confidence: 99%

Gestational diabetes and the neonate: challenges and solutions

Stewart¹,

Malhotra²

2015

RRN

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Abstract:The prevalence of gestational diabetes mellitus (GDM) is rising worldwide, along with overweight and obesity. In utero exposure to hyperglycemia increases perinatal complications including preterm birth, macrosomia, neonatal respiratory distress, hypoglycemia, and polycythemia. More significantly, GDM places the offspring at risk of insulin resistance and type 2 diabetes mellitus, obesity and cardiovascular disease. The relative contributory roles of the intrauterine environment, shared genes, and postnatal environment on long-term outcomes are not yet fully understood. Maternal obesity in particular remains a significant confounding factor. Opportunities for ameliorating both the perinatal effects and long-term and intergenerational effects of GDM exist at the level of prevention of GDM, screening for and treatment of GDM, and postnatal interventions in offspring.

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The offspring of the diabetic mother – Short- and long-term implications

Cited by 161 publications

References 96 publications

The Impact of Kidney Development on the Life Course: A Consensus Document for Action

The Impact of Kidney Development on the Life Course: A Consensus Document for Action

Desenlaces maternos, fetales y perinatales de las gestantes con diabetes en manejo con bomba de insulina en el Hospital Universitario San Ignacio

Gestational diabetes and the neonate: challenges and solutions

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