The odontogenic cyst as a potential carcinoma: a clinicopathologic appraisal

Gardner, Alvin F.

doi:10.14219/jada.archive.1969.0290

Cited by 125 publications

(35 citation statements)

References 17 publications

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“…The so-called kerato-ameloblastoma is a rare variant of ameloblastoma that contains prominent keratinizing cysts that may cause some alarm and distract the pathologist from the otherwise ameloblastomatous feature (6,14). An additional consideration in the differential diagnosis is the squamous cell carcinoma arising in the lining of an odontogenic cyst (15). Thus, the term ameloblastic carcinoma can be applied to our case, which showed focal histologic evidence of malignant disease including cytologic atypia and mitoses with indisputable features of classic ameloblastoma.…”

Section: Discussionmentioning

confidence: 96%

Ameoblastic carcinoma of mandible - A rare case report with review of literature

Mubeen¹,

Shakya²,

Jigna³

2010

J Clin Exp Dent

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Ameloblastic carcinoma is a rare malignant lesion with characteristic histologic features and behavior that dictates more aggressive surgical approach than that of a simple ameloblastoma. However, reliable evidence of its biologic activity is currently unavailable due to the scarcity of well-documented cases. It occurs primarily in the mandible in a wide range of age groups; no sex or race predilection has been noted. It may present as a cystic lesion with benign clinical features or as a large tissue mass with ulceration, significant bone resorption and tooth mobility. Because the lesion is usually found unexpectedly after an incisional biopsy or the removal of a cyst, a guide to differential diagnosis is not usually useful. The identifying features of ameloblastic carcinoma must be known and recognized by dental practitioners. The tumour cells resemble the cells seen in ameloblastoma, but they show cytologic atypia. Moreover, they lack the characteristic arrangement seen in ameloblastoma. Direct extensions of the tumour, lymph node involvement and metastasis to various sites (frequently the lung) have been reported. We present a case of ameloblastic carcinoma of the mandible with a clinical course of typical aggressiveness and extensive local destruction in a 27 year old male patient.

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Section: Discussionmentioning

confidence: 96%

Ameoblastic carcinoma of mandible - A rare case report with review of literature

Mubeen¹,

Shakya²,

Jigna³

2010

J Clin Exp Dent

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“…Relatively few metastases to the lymph node have been found. There were no metastasis associated with squamous cell carcinomas derived from odontogenic cysts among 25 cases with central squamous carcinoma of the jaw, investigated by Gardener 30,31) . On the other hand, Waldron et al 36 Table 2 Histological types of malignant tumors arising from a dentigerous cyst J.Hard Tissue Biology Vol.…”

Section: Discussionmentioning

confidence: 98%

“…The three diagnostic criteria of Gardner 30,31) are widely accepted: 1) a microscopic transition area from benign cystic epithelial lining to invasive malignant squamous cell carcinoma; 2) no carcinoma changes in the overlying epithelium; 3) no source of carcinoma in the adjacent structures. In our case, in accordance with criterion 1, CK17-positive and CK19-negative findings that corresponded to an in situ lesion were detected as illustrated by histopathological findings (Fig.…”

Section: Discussionmentioning

confidence: 99%

Primary Intraosseous Odontogenic Carcinoma Arising from a Dentigerous Cyst

Uchida

Ochiai

Sinohara

et al. 2013

J. Hard Tissue Biology.

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Malignant tumors arising from dentigerous cysts are classified as primary squamous cell carcinoma derived from an odontogenic cyst or as odontogenic carcinoma according to the 2005 WHO classification and are extremely rare. We report a malignant tumor arising from a dentigerous cyst in the right maxillary anterior teeth , together with a literature review. The patient was a 75-year-old man who visited a hospital with complaining of discomfort in the lingual part of the right maxillary anterior teeth. On panoramic radiography and plain computed tomography (CT), dentigerous cyst, keratocystic odontogenic tumor or ameloblastoma was suspected. The extirpated material was histopathologically diagnosed as an odontogenic carcinoma (in situ) arising from the dentigerous cyst. Postoperative ultrasonography (US) and contrast enhanced CT revealed no metastasis to the cervical lymph nodes. The patient is currently being followed up without resection or anticancer drug administration. Neither local recurrence nor metastases were observed 18 month after surgery.

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“…It remains difficult for the diagnostician to differentiate between cancers that arise de novo or as carcinoma ex-odontogenic cysts/KCOT. Criteria proposed by Gardner [46,58,59] could be used to identify 'carcinomas ex-odontogenic cysts', which may also be applicable for diagnosing malignant transformation in KCOT (Table 4).…”

Section: Prognosis Recurrence and Malignant Transformationmentioning

confidence: 99%