Keratocystic odontogenic tumour (KCOT)—a cyst to a tumour

Bhargava, Darpan; Deshpande, Ashwini; Pogrel, M. Anthony

doi:10.1007/s10006-011-0302-9

Cited by 66 publications

(60 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Such findings can be explained by the high epithelial proliferation rate of these tumors, which is responsible for the growth mechanism of these lesions. 11,12 The smooth junction between the thin epithelium and the connective tissue of the capsule 12 may also be a likely source of stimulation for the desquamation process.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the cell block technique as an auxiliary method of diagnosing jawbone lesions

et al. 2012

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Evaluation of the cell block technique as an auxiliary method of diagnosing jawbone lesions

et al. 2012

View full text Add to dashboard Cite

“…In recent years, the World Health Organization (WHO) revised its name to keratocystic odontogenic tumor (KCOT). This reclassification is based on its aggressive behavior and high recurrence rate, emphasizing that KCOT is a benign tumor rather than a cyst [1-3]. Although the great majority of keratocysts occur in isolation as single, non-syndromic cysts, they may also present as multiple cysts as a feature of the nevoid basal cell carcinoma syndrome (Gorlin syndrome, OMIM#109400) [4].…”

Section: Introductionmentioning

confidence: 99%

Smoothened gene alterations in keratocystic odontogenic tumors

et al. 2014

View full text Add to dashboard Cite

BackgroundIt has been widely demonstrated that the hedgehog pathway is strongly associated with basal cell carcinoma of the skin (NBCCS). To assess potential DNA alterations related to keratocystic odontogenic tumors (KCOTs), we sequenced smoothened (SMO) genes in 12 sporadic KCOTs.MethodsPolymerase chain reaction (PCR), capillary electrophoresis and dideoxy chain-termination sequencing were used to examine potential DNA alterations in sporadic KCOTs.ResultsFive alterations in SMO genes were detected. Four of these mutations consisted of two synonymous and three missense mutations; two of which have not been reported to date (c.T776A, c.T1281G).ConclusionsSMO genes may play an important role in the sonic hedgehog (SHH) pathway and could also be responsible for generating KCOTs and NBCCS. However, their influence on SHH signaling remains to be elucidated.

show abstract

“…KCOTs are one of the most frequent odontogenic tumors and they receive significant attention due to their aggressive biological behavior and tendency for recurrence (8). Decompression is commonly employed as a conservative treatment for KCOT.…”

Section: Discussionmentioning

confidence: 99%

Differential expression of inducible nitric oxide synthase in keratocystic odontogenic tumors prior and subsequent to decompression

Song

Zhang

et al. 2016

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. The aim of the present study was to investigate the expression of inducible nitric oxide synthase (iNOS) in keratocystic odontogenic tumors (KCOTs) prior and subsequent to decompression and to explore the association between iNOS expression and changes in clinical features. Sixteen pairs of specimens obtained at the time of decompression and subsequent curettages were collected and immunohistochemically examined using an antibody against iNOS. The intensity of iNOS staining was evaluated semi-quantitatively for statistical analysis. Prior to decompression, 87.5% of KCOT samples showed no immunohistochemical reactivity for iNOS. Only 12.5% of samples exhibited slight staining for iNOS in the cytoplasm of cells in the epithelial layer. Subsequent to decompression, all the samples exhibited moderate to intense staining for iNOS in the cytoplasm and membrane of cells in the epithelial and fibrous layers. This increased expression of iNOS following decompression was statistically significant (P<0.01). The results demonstrated distinct expression of iNOS in KCOT samples prior and subsequent to decompression, indicating that iNOS may have a role in mediating changes in clinical features.

show abstract

Keratocystic odontogenic tumour (KCOT)—a cyst to a tumour

Cited by 66 publications

References 50 publications

Evaluation of the cell block technique as an auxiliary method of diagnosing jawbone lesions

Evaluation of the cell block technique as an auxiliary method of diagnosing jawbone lesions

Smoothened gene alterations in keratocystic odontogenic tumors

Differential expression of inducible nitric oxide synthase in keratocystic odontogenic tumors prior and subsequent to decompression

Contact Info

Product

Resources

About