The ocular pulse amplitude at different intraocular pressure: a prospective study

Abstract

. Purpose: To investigate changes in ocular pulse amplitude (OPA) during a short‐term increase in intraocular pressure (IOP) and to assess possible influences of biometrical properties of the eye, including central corneal thickness (CCT) and axial length. Methods: In a prospective, single centre study, OPA and IOP as measured by dynamic contour tonometry (DCT) were taken before baseline‐ and post‐OPA (delta) intravitreal injection of 0.05 ml anti‐vascular endothelial growth factor agents. Analysis was performed employing linear regression with baseline‐ and post (delta)‐OPA differences as the dependent and post‐IOP as well as delta IOP as the independent variable. A multilinear regression analysis with delta OPA as the dependent variable and baseline IOP, post‐IOP, CCT and axial length as independent variables was conducted. Results: Forty eyes of 40 patients were included. IOP and OPA increased significantly after injection (IOP mean increase ± SD: 17.83 ± 9.83 mmHg, p < 0.001; OPA mean increase ± SD: 1.39 ± 1.16 mmHg, p < 0.001). For every mmHg increase in IOP, the OPA showed a linear increase of 0.05 mmHg (slope 0.05, 95% CI: 0.02–0.09, p = 0.003, r2 = 0.20). Multiple regression analysis with delta OPA as the dependent variable revealed a partial correlation coefficient of 0.47 (p = 0.003) for post‐IOP as the only significant contribution. Conclusion: A clear positive relationship between OPA measurements and IOP levels was shown in a clinical routine setting using DCT focusing on baseline and postinterventional comparisons of OPA values after intravitreal injections in patients with exudative age related macular degeneration. When considering the OPA for diagnostic purposes, we recommend indication of corresponding IOP values.

Stellenwert der okulären Pulsamplitude beim Glaukom

“…mmHg) berichten. Der direkte Zusammenhang zwischen der OPA und dem Augeninnendruck konnte auch bei augengesunden Probanden durch eine medikamentöse Drucksenkung[7] oder Steigerung unmittelbar nach intravitrealen Injektionen[8] gezeigt werden. Keine der anderen untersuchten Parameter (Alter, Hornhautdicke, Vorderkammertiefe, Hornhautradius, Astigmatismus, systolischer oder diastolischer Blutdruck, Blutdruckamplitude oder Puls) zeigten einen signifikanten Einfluss auf die OPA.…”

Modeling the Origin of the Ocular Pulse and Its Impact on the Optic Nerve Head

“…This phenomenon has been observed in both population-based measurements 1 (0.12 mm Hg of OPA / 1 mm Hg of IOP) and in experiments where saline was injected into the eye to artificially increase IOP (0.05-0.073 mm Hg of OPA / 1 mm Hg of IOP). 9,66 We also observed a decreased pulse volume for a higher baseline IOP, which could be due to a decreased ocular perfusion pressure. This has also been reported in experimen-tal measurements (29% pulse volume decrease as IOP increased from 20 to 40 mm Hg).…”

Effect of selective laser trabeculoplasty on ocular haemodynamics in primary open‐angle glaucoma

“…Ocular pulse amplitude (OPA) was not influenced by IOP change following SLT in this group of glaucoma patients. Previous studies have shown that there is a positive correlation between IOP and OPA in healthy subjects (Kaufmann et al 2006;Knecht et al 2011). This is necessary to maintain a relatively constant level of blood flow when IOP changes and is a sign of functioning autoregulation.…”

“…Previous studies have shown that there is a positive correlation between IOP and OPA in healthy subjects (Kaufmann et al 2006;Knecht et al 2011). Previous studies have shown that there is a positive correlation between IOP and OPA in healthy subjects (Kaufmann et al 2006;Knecht et al 2011).…”