Modeling the Origin of the Ocular Pulse and Its Impact on the Optic Nerve Head

Jin, Yuejiao; Wang, Xiaofei; Zhang, Liang; Jonas, Jost B.; Aung, Tin; Schmetterer, Leopold; Girard, M

doi:10.1167/iovs.17-23454

Cited by 18 publications

(32 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using FE modelling, we previously modelled the origin of the ocular pulse and its effect on the ONH. 19 We found that a change in arterial pressure (as that occurring from diastole to systole) resulted in choroidal swelling, which in turn induced a change in IOP (the OPA) due to the incompressibility of the vitreous. Both the OPA and choroidal swelling were responsible for deforming the ONH tissues, and a relatively large shearing of neural tissues was observed within the neuroretinal rim.…”

Section: Methodsmentioning

confidence: 80%

“…The geometry of the three-dimensional eye model was adapted from our previous studies. 12, 19, 24 In summary, the eye globe and optic nerve were reconstructed from magnetic resonance imaging images of a heathy subject. The corneoscleral shell was assumed to be spherical with an outer diameter of 24 mm and thickness of 1 mm.…”

Section: Methodsmentioning

confidence: 99%

“…Reconstructed geometry and FE mesh of the whole eye model adopted from Jin. 19 ONH structures (including the LC, sclera, neural tissues, choroid, BM, border tissue, pia and dura) were reconstructed using average measurements from the literature. 9, 19, 24, 26, 68 …”

Section: Methodsmentioning

confidence: 99%

“…blood) to allow for changes in blood pressure during the cardiac cycle and the movement of blood within the choroid. 19 All biomechanical parameters are listed in Table 1 .…”

Section: Methodsmentioning

confidence: 99%

“…ONH deformations can indeed be measured by using the ocular pulse as the load, 18 and from such data, modelling can help us interpret these deformation data to derive stiffness estimates for the ONH. 19…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head

Jin

Wang

Irnadiastputri

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

ABSTRACTPurposeTo study the effect of changing heart rate on the ocular pulse and the dynamic biomechanical behaviour of the optic nerve head (ONH) using a comprehensive mathematical model.MethodsIn a finite element model of a healthy eye, a biphasic choroid consisted of a solid phase with connective tissues and a fluid phase with blood, and the lamina cribrosa (LC) was viscoelastic as characterized by a stress-relaxation test. We applied arterial pressures at 18 ocular entry sites (posterior ciliary arteries) and venous pressures at four exit sites (vortex veins). In the model, the heart rate was varied from 60 bpm to 120 bpm (increment: 20 bpm). We assessed the ocular pulse amplitude (OPA), pulse volume, ONH deformations and the dynamic modulus of the LC at different heart rates.ResultsWith an increasing heart rate, the OPA decreased by 0.04 mmHg for every 10 bpm increase in heart rate. The ocular pulse volume decreased linearly by 0.13 µL for every 10 bpm increase in heart rate. The storage modulus and the loss modulus of the LC increased by 0.014 MPa and 0.04 MPa, respectively, for every 10 bpm increase in heart rate.conclusionsIn our model, the OPA, pulse volume, and ONH deformations decreased with an increasing heart rate, while the LC became stiffer. The effects of blood pressure / heart rate changes on ONH stiffening may be of interest for glaucoma pathology.SupportSingapore Ministry of Education, Academic Research Fund, Tier 2 (R-397-000-280-112).Commercial relationshipNone

show abstract

Section: Methodsmentioning

confidence: 80%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…blood) to allow for changes in blood pressure during the cardiac cycle and the movement of blood within the choroid. 19 All biomechanical parameters are listed in Table 1 .…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head

Jin

Wang

Irnadiastputri

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Effects of Tafluprost on Ocular Blood Flow

et al. 2022

View full text Add to dashboard Cite

Increasing evidence indicates that improving ocular blood flow (OBF) can be a therapeutic direction for glaucoma therapy. Tafluprost, a prostaglandin analogue which lowers the intraocular pressure (IOP), has been shown to improve OBF in animals and humans. Several animal experiments showed that topical tafluprost significantly increased optic nerve head and retinal blood flow. Clinical trials also showed a beneficial effect of tafluprost on optic nerve head and macula blood flow, and a good ocular pulse amplitude-lowering effect. But, there are still a few conflicting results. Overall, tafluprost seems to have a beneficial effect on OBF, and the positive effect is probably independent from its IOP-lowering effect, which also is expected to improve OBF. Moreover, reducing the intracellular free Ca 2+ concentration may be a possible mechanism of tafluprost’s effect on OBF. More well-designed studies are required to reveal the truth.

show abstract

Artificial intelligence and deep learning in glaucoma: Current state and future prospects

Girard

Schmetterer

2020

Progress in Brain Research

View full text Add to dashboard Cite

Modeling the Origin of the Ocular Pulse and Its Impact on the Optic Nerve Head

Abstract: Our models indicate that, during the cardiac cycle, the OPA and choroidal expansion can deform the ONH with a net shearing of neural tissues within the neuroretinal rim.

Cited by 18 publications

References 89 publications

Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head

Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head

Effects of Tafluprost on Ocular Blood Flow

Artificial intelligence and deep learning in glaucoma: Current state and future prospects

Contact Info

Product

Resources

About