The Occurrence of L.E. Cells and Hematoxylin Bodies in the Naturally Occurring Cutaneous Lesions of Systemic Lupus Erythematosus

Rm, Wilson; Rr, Abbott; Dk, Miller

doi:10.1097/00000441-196101000-00005

Cited by 15 publications

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“…I n one patient with terminal systemic lupus erythematosus, LE cells were found in direct peripheral blood smears (4). LE cells also were seen on histologic examination of a cutaneous lesion of a patient with systemic lupus erythematosus (5). I n the present study, LE cells were frequently found in synovial effusions of patients whose blood LE clot tests (1) showed LE cells.…”

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confidence: 60%

In Vivo LE Cell Formation in Synovial Fluid

Hunder

Pierre

1970

Arthritis & Rheumatism

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Smears of synovial fluid specimens from 7 of 10 selected patients were found to contain lupus erythematosus (LEI cells. In 1 patient, LE cells were found in smears of synovial fluid but not of blood. Direct smears of synovial fluid immediately after aspiration from 2 patients contained LE cells, thus suggesting that in vivo these cells form in synovial fluid.Usually, the formation of lupus erythematosus (LE) cells is considered an in vitro phenomenon (1-3).Only in rare instances has it been demonstrated that LE cells formed in vivo. I n one patient with terminal systemic lupus erythematosus, LE cells were found in direct peripheral blood smears (4). LE cells also were seen on histologic examination of a cutaneous lesion of a patient with systemic lupus erythematosus (5). I n the present study, LE cells were frequently found in synovial effusions of patients whose blood LE clot tests (1) showed LE cells. Evidence was obtained showing that in some patients, LE cells form in vivo. MATERIALS AND METHODSSynovial fluid was obtained from the knees of 4 women and 5 men, between the ages of 32 and 69 years, whose peripheral blood LE cell clot tests showed LE cells. A tenth patient, a woman, was From the

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confidence: 60%

In Vivo LE Cell Formation in Synovial Fluid

Hunder

Pierre

1970

Arthritis & Rheumatism

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“…In patients with systemic lupus erythematosus, hematoxylin bodies may be found in lymph nodes and sometimes other sites, such as kidney and skin. 53 -57 In lymph nodes, hematoxylin bodies are found predominantly in sinusoids but also in the nodal parenchyma or around blood vessels. Hematoxylin bodies are pathognomonic of systemic lupus erythematosus when present.…”

Section: Colors Of Extracellular Substancesmentioning

confidence: 99%

The Wonderful Colors of the Hematoxylin–Eosin Stain in Diagnostic Surgical Pathology

2014

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The hematoxylin-eosin (H&E) stain has stood the test of time as the standard stain for histologic examination of human tissues. This simple dye combination is capable of highlighting the fine structures of cells and tissues. Most cellular organelles and extracellular matrix are eosinophilic, while the nucleus, rough endoplasmic reticulum, and ribosomes are basophilic. This review discusses the spectrum, intensity, and texture of colors observed in H&E-stained slides to illustrate their value in surgical pathology diagnosis. Changes in color of the nuclei occur in the presence of nuclear pseudoinclusions (such as papillary thyroid carcinoma) or inclusions (such as viral infection, surfactant, immunoglobulin, and biotin). The color of the cytoplasm of spindly cells can provide clues to their nature, such as basophilic (fibroblast), eosinophilic (smooth muscle and others), and amphophilic (myofibroblast). Eosinophilic globules have diagnostic value for sclerosing polycystic adenosis of salivary gland, low-grade B-cell lymphoma, solid pseudopapillary tumor of pancreas, and inclusion body fibromatosis. Eosinophilic granules are characteristic of granular cells (lysosome-rich), oncocytic cells (mitochondria-rich), and cells with secretory products (including neuroendocrine cells). Eosinophilic crystals can be diagnostic of lymphoma/plasmacytoma and crystal-storing histiocytosis. Basophilic granules or inclusions are diagnostic of acinic cell carcinoma and malakoplakia (Michaelis-Gutmann bodies). Yellow or brown inclusions are characteristic of hyalinizing trabecular adenoma of thyroid (yellow bodies), brown bowel syndrome, and malignant melanoma. Extracellular eosinophilic deposits can be produced by many conditions, but amyloid and monoclonal immunoglobulin deposition disease are important considerations. Extracellular basophilic deposits may be seen in small cell carcinoma and systemic lupus erythematosus, but they differ in that the former is blue (nuclear material) while the latter is purple (nuclear material plus immunoglobulin).

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“…In vivo L E cells have been found primarily in serous effusions from patients with SLE, including pleural (38)(39)(40)(41)(42), pericardial (43,44), peritoneal (49, and synovial fluids (37,46). There are also isolated, rare reports of their presence in cerebrospinal fluid (47) and in certain body tissues (48,49). In addition, Chomet et al, in 1953 (50), reported the discovery of LE cells in smears of untreated, freshly drawn peripheral blood obtained from a "terminal" lupus patient shortly before her death.…”

Section: Discussionmentioning

confidence: 99%

Synovial fluid characteristics and the lupus erythematosus cell phenomenon in drug‐induced lupus. Findings in three patients and review of pertinent literature

Vivino

Schumacher

1989

Arthritis & Rheumatism

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The characteristics of synovial fluid obtained from 3 patients with drug-induced lupus erythematosus are described. Two patients had "inflammatory" counts of synovial leukocytes, in the range of 2,500-39,000/ mm3, with mononuclear predominance in 1 patient and neutrophil predominance in the other. The third patient had "noninflammatory" fluid, with mononuclear predominance. Lupus erythematosus cells formed in vivo were observed in the synovial fluid of 2 of the patients. Biopsy of the synovium of 1 patient showed nonspecific chronic inflammatory changes. Our findings in these patients with drug-induced lupus are indistinguishable from those previously described in patients with idiopathic lupus erythematosus.

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The Occurrence of L.E. Cells and Hematoxylin Bodies in the Naturally Occurring Cutaneous Lesions of Systemic Lupus Erythematosus

Cited by 15 publications

References 0 publications

In Vivo LE Cell Formation in Synovial Fluid

In Vivo LE Cell Formation in Synovial Fluid

The Wonderful Colors of the Hematoxylin–Eosin Stain in Diagnostic Surgical Pathology

Synovial fluid characteristics and the lupus erythematosus cell phenomenon in drug‐induced lupus. Findings in three patients and review of pertinent literature

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