The Occurrence of Immunoglobulins in the Dermo-Epidermal Junction of the Skin in Lupus Erythematosus and Related Syndromes

Kalsbeek, G.L.; Cormane, R. H.

doi:10.1159/000254182

Cited by 38 publications

(9 citation statements)

References 10 publications

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“…Eurthermore immunofluorescence findings showed features of both diseases. Deposits of immunogiobulins, C3 and fibrin at the dermo-epidermal junction as seen in our three patients are typical of LE (Kalsbeek & Cormane, 1967). However, Cases i and 3 showed colloid body staining for IgM and fibrin, a finding seen in both LE and LP (Michel, 1973, Abell et al, 1975.…”

Section: Test For Active Epidermal Cell Movement In Vitromentioning

confidence: 50%

Is there a relationship between lupus erythematosus and lichen planus?

et al. 1977

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Section: Test For Active Epidermal Cell Movement In Vitromentioning

confidence: 50%

Is there a relationship between lupus erythematosus and lichen planus?

et al. 1977

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“…The ANA test was performed in Rothfield's 12 cases and was positive in i case. Kalsbeek & Cormane (1967) reported that the LE clot test was negative in their 12 patients, whereas the ANA test was positive in 3. In the 12 patients, direct IF procedure showed immunoglobulin deposition at the dermalepidermal juncdon in lesional skin, whereas only 3 padents had a similar finding in uninvolved skin.…”

Section: Discussionmentioning

confidence: 99%

A Study of lupus erythematosus with particular reference to generalized discoid lupus

1978

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SUMMARY The classification of lupus erythematosus (LE) is difficult because of variable and multisystem involvement, occurrence of transitional forms, and overlapping with connective tissue disorders. One of the earliest attempts at classification was made by O'Leary (1934), who classified LE clinically into four main types: (1) chronic discoid lupus erythematosus (DLE), or fixed type with the typical erythematous, scaly, well‐demarcated eruption, usually showing follicular plugging and atrophy, confined to the head region; (2) generalized DLE, or chronic disseminated type differing from the localized discoid type in that the erythematous plaques are found not only on the head area but also below the neck region (O'Leary considered that constitutional systems were generally lacking in these two types); (3) subacute disseminated LE; and (4) acute disseminated LE. The last two categories reflect what we now call systemic lupus erythematosus (SLE) of varying severity. Many authors have used O'Leary's clinical classification, but progress in laboratory medicine—in particular the discovery of the LE cell—has led to other schemes, the most widely accepted at present being that related to the American Rheumatism Association's (ARA) preliminary criteria for the diagnosis of SLE (Cohen et al., 1971). These criteria have been criticized by many authorities because they do not include important data, such as those relative to the antinuclear antibody test, serum anti‐native‐DNA, serum complement levels, many neurological abnormalities, renal biopsy changes, and cutaneous immunofluorescent (IF) findings. However, Dubois (1974b) pointed out that all categorizations of LE are arbitrary, and he accepted the ARA criteria as a successful method for differentiating LE. This report involves the clinical and laboratory findings in 123 patients with LE seen at the Mayo Clinic during the 3‐year period 1971–1974 and an assessment of the validity and usefulness of O'Leary's classification.

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“…4 The prevalence of positive LBT is much higher in lesional than in non-lesional skin, as well as in clinically normal sun-exposed skin than in clinically normal non-sun-exposed skin. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] In particular, Fabre et all 8 found a bright continuous band of Igs along the DEJ in 10 out of 50 sun-exposed skin specimens (20%) of normal healthy adults; this band was composed of only IgG in one patient, only IgA in two patients, IgG and IgA in two patients, and IgG, There are many studies in which the LBT was performed on SPNL skin in SLE patients,19-36 but only few of these stated whether cutaneous involvement was present at the time of the biopsy.20-24 Four studies20-23 analysed the LBT in patients with localized and generalized DLE and only one study examined the immunologic characteristics of LBT in subacute cutaneous lupus erythematosus (SCLE) patients. 24 As is known, LE is a chronic, autoimmune, inflammatory disease characterized by a broad spectrum of clinical varieties.…”

Section: Introductionmentioning

confidence: 99%

The composition of the lupus band test (LBT) on the sun-protected non-lesional (SPNL) skin in patients with cutaneous lupus erythematosus (CLE)

Cardinali

Caproni²,

Fabbri

1999

Lupus

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The objective of this study was to analyse the different immunoreactants at the dermo-epidermal junction (DEJ) of patients with cutaneous lupus erythematosus (CLE). Sun-protected non lesional (SPNL) skin biopsies from 65 patients with specific cutaneous manifestations of LE and from 18 patients with other dermatologic diseases were tested using the direct immunofluorescence (DIF) technique. Nineteen out of 65 patients with CLE were affected by systemic LE (SLE). We used the conventional chi-squared test to analyse statistical differences between CLE-SLE and CLE-non-SLE groups in the immunological composition of lupus band test (LBT).C3 was the most common component while IgM were the most frequent immunoglobulins (Igs) of LBT in LE patients. No immunoreactants could be demonstrated at the DEJ in patients with other dermatologic diseases. No statistical differences could be found between CLE-SLE and CLEnon-SLE groups as regards the detection of the different immunoreactants at the DEJ. A positive LBT (even for the presence of only one immunoreactant at the DEJ) performed on SPNL skin represents a useful and specific criterion to distinguish patients with lupus erythematosus (LE) from those without LE. We also believe in a prognostic value of a positive LBT on SPNL skin when the deposition of at least two immunoreactants is demonstrated, and especially if the deposits are composed of IgG.

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The Occurrence of Immunoglobulins in the Dermo-Epidermal Junction of the Skin in Lupus Erythematosus and Related Syndromes

Cited by 38 publications

References 10 publications

Is there a relationship between lupus erythematosus and lichen planus?

Is there a relationship between lupus erythematosus and lichen planus?

A Study of lupus erythematosus with particular reference to generalized discoid lupus

The composition of the lupus band test (LBT) on the sun-protected non-lesional (SPNL) skin in patients with cutaneous lupus erythematosus (CLE)

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