Is there a relationship between lupus erythematosus and lichen planus?

Davies, Morton R.; Górkiewicz, A; Knight, Arthur; Marks, R.

doi:10.1111/j.1365-2133.1977.tb12536.x

Cited by 56 publications

(16 citation statements)

References 22 publications

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“…Lichen planus may occasionally appear clinically similar to lupus erythematosus and histologically both diseases are characterized by an erosive process affecting the lower epidermis. Copeman et al (1970) and Davies et al (1977) have described cases showing features of both lupus erythematosus and lichen planus together and it has been suggested that these may result from common pathophysiological pathways (Davies et al, 1977). Further corroborative evidence that lichen planus may have an immunopathological aetiology is obtained from reports that lichen planus can occur in association with diseases associated with immunological disturbances.…”

Section: Immunopathological Findings In Lichen Planusmentioning

confidence: 96%

What is going on in lichen planus?

Black

1977

Clin Exp Dermatol

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Section: Immunopathological Findings In Lichen Planusmentioning

confidence: 96%

What is going on in lichen planus?

Black

1977

Clin Exp Dermatol

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“…The signs in LP and in lupus erythematosus may be difficult to distinguish and in each disease be so variable that the overlap might be blamed on a common aetiological agent (Davies et al, 1977), the pathological consequences of which are being expressed in different genetic backgrounds. The genotypic associations are unproven, but seemingly systemic lupus erythematosus is allied to HLA-B7 (Millard, Rowell & Rajah, 1977).…”

Section: P Wmcopeman Et Almentioning

confidence: 99%

Familial lichen planus ANOTHER DISEASE OR A DISTINCT PEOPLE?

et al. 1978

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When lichen planus strikes families, a very rare happening, it is likely to afflict younger members, to erupt more acutely, extensively, and gravely, attacking also nails and mucous membranes, and to recur. Ten patients with familial lichen planus, two each from five distinct Caucasian families, the parents of whom were unrelated by birth, were found to be carrying HLA-B7 statistically more frequently than in the normal population or in those with the characteristic forms of lichen planus. We hint that their genotype might have rendered them susceptible to a pathogen that precipitated their disease.

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“…The clinical presentation of OLP seems to be influenced by the concomitant disease: the erosive form has been reported as more commonly associated with CLD (Bagan et al, 1992 Bologa and Valda, 1971;Grupper et al, 1972Tan, 1974a,b Okoki et al, 1990Cottoni etal., 1991Davies et al, 1977Van der Horst et al, 1983Brenner et al, 1979Connelly et al, 1985Tan, 1972Aronson et al, 1978;Miller, 1971;Samman, 1974Neuman-Jensen et al, 1980Neuman-Jensen et al, 1980Lotem et al, 1989;Lee, 1987Shultleworth et al, 1986Rustin, 1986;Lundstr6m et al, 1982Blasberg et al, 1984Kaplan et al, 1995Zijdenbos et al, 1985Gart, 1994;Bermejo Fenoll andLopez Jornet, 1991 Parodi et al, 1995;Brenner et al, 1979Coltoni et al, 1988Tan, 1974;Mann et al, 1982;Porter et al, 1994;Brenner et al, 1979(Rebora et al, 1978. The results obtained from later research carried out in southern Europeans, particularly in Spain and Italy (Ayala et al, 1986;Cottoni et al, 1988;del Olmo et al, 1989;GISED, 1990), and also in Japanese (Nagao et al, 1995a) (Powell et al, 1983;Mobacken et al, 1984c;…”

Section: (3) Drugsmentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

467

461

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Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

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Is there a relationship between lupus erythematosus and lichen planus?

Cited by 56 publications

References 22 publications

What is going on in lichen planus?

What is going on in lichen planus?

Familial lichen planus ANOTHER DISEASE OR A DISTINCT PEOPLE?

Update On Oral Lichen Planus: Etiopathogenesis and Management

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