The occurrence of electron dense intercellular materials and gap junctions in the human intestinal epithelium.

Sano, Hiroshi; Konno, Tasuke; Igarashi, Yutaka; Yamamoto, T.

doi:10.1620/tjem.121.301

Cited by 5 publications

(1 citation statement)

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“…Adjacent IECs are connected by junctional complexes (10). Among these, tight junctions form belt-like structures that encircle the apical end of IECs and separate the surface of IECs into apical and basolateral surfaces (Fig.…”

Section: Overview Of the Siga Systemmentioning

confidence: 99%

Polymeric immunoglobulin receptor

Asano

Komiyama

2011

J Oral Sci

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Section: Overview Of the Siga Systemmentioning

confidence: 99%

Polymeric immunoglobulin receptor

Asano

Komiyama

2011

J Oral Sci

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Intercellular material in the basal and lateral folds of parotid serous cells in four species of bats

1998

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Background: Basal folds are slender plications at the basal surface of acinar cells in the salivary glands of many mammalian species. These largely organelle-free folds increase the surface area of the basal plasmalemma manyfold and are unquestionably involved in the translocation of organic and inorganic molecules and water into the acinar cells.Methods: Specimens of salivary glands were obtained from over 230 species of live-trapped bats from major areas of the globe. Tissues for electron microscopy were fixed and processed by conventional means.Results: A number of the bat species examined had dense material in the intercellular spaces between basal and lateral folds of serous cells in the parotid gland. This intercellular material was particularly prominent in three species of New World bats, viz., Pteronotus parnellii, P. quadridens, and Phyllostomus latifolius, and in one species of Old World bats, Chalinolobus argentatus. This dense material, which has a farinaceous texture, appears not to pass through tight junctions, so it is excluded from the lumina of intercellular canaliculi and acini. The dense material originates in the acinar cells-it is carried to the membranes of the folds via coated vesicles, which empty their dense content by exocytosis into the intercellular space. Similar dense material is present in the intercellular spaces of the basal labyrinth of striated ducts in the two species of Pteronotus. The manner in which this material accumulates in the striated duct is unclear.Conclusions: Although the function of the intracellular dense material is undetermined, it appears to be placed strategically to influence molecular traffic into acinar cells or to modulate the paracellular pathway. From a comparative evolutionary perspective, we hypothesize that, in bats, the combination of basal folds and extracellular densities is associated with insectivory. Similar morphologies appear to be lacking in frugivorous or nectarivorous species. Anat.

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Establishment and characterization of a human acute monocytic leukemia cell line (THP‐1)

Tsuchiya

Yamabe

Yamaguchi

et al. 1980

Intl Journal of Cancer

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A human leukemic cell line (THP-1) cultured from the blood of a boy with acute monocytic leukemia is described. This cell line had Fc and C3b receptors, but no surface or cytoplasmic immunoglobulins. HLA haplotypes of THP-1 were HLA-A2, -A9, -B5, -DRW1 and -DRW2. The monocytic nature of the cell line was characterized by: (1) the presence of alpha-naphthyl butyrate esterase activities which could be inhibited by NaF; (2) lysozyme production; (3) the phagocytosis of latex particles and sensitized sheep erythrocytes; and (4) the ability to restore T-lymphocyte response to Con A. The cells did not possess Epstein-Barr virus-associated nuclear antigen. These results indicate that THP-1 is a leukemia cell line with distinct monocytic markers. During culture, THP-1 maintained these monocytic characteristics for over 14 months.

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The occurrence of electron dense intercellular materials and gap junctions in the human intestinal epithelium.

Cited by 5 publications

References 19 publications

Polymeric immunoglobulin receptor

Polymeric immunoglobulin receptor

Intercellular material in the basal and lateral folds of parotid serous cells in four species of bats

Establishment and characterization of a human acute monocytic leukemia cell line (THP‐1)

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