Polymeric immunoglobulin receptor

Asano, Masaharu; Komiyama, Kanki

doi:10.2334/josnusd.53.147

Cited by 98 publications

(96 citation statements)

References 80 publications

(79 reference statements)

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“…Most IgA in the proximal intestine of rodents results from the hepatobiliary transport of this antibody from blood to bile via pIgR transcytosis (Asano and Komiyama 2011;Brown and Kloppel 1989). The current results indicate that the present protocol of intermittent fasting (followed by 2 weeks of ad libitum feeding) enhanced hepatic pIgR mRNA levels to a greater extent on day 14 than day 7 post-infection, while increasing this parameter at the intestinal level on day 7.…”

Section: Discussionmentioning

confidence: 53%

“…Although expression of pIgR is constitutive, it also can be modulated by pro-inflammatory cytokines such as TNF-α (Asano and Komiyama 2011).…”

Section: Discussionmentioning

confidence: 99%

“…The dIgA-pIgR complex is internalized and transcytosed to the apical membrane. There, the extracellular region of pIgR is proteolytically cleaved and released into the lumen along with dIgA to render secretory IgA (SIgA) (Asano and Komiyama 2011). SIgA and pIgR have an essential role to the control of an S. typhimurium infection at the intestinal level by blocking luminal colonization, thus enabling bacterial clearance (Michetti et al 1992;Wijburg et al 2006).…”

Section: Introductionmentioning

confidence: 99%

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Intermittent fasting favored the resolution of Salmonella typhimurium infection in middle-aged BALB/c mice

Campos-Rodrı́guez

Godínez‐Victoria

Reyna-Garfias

et al. 2016

AGE

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Section: Discussionmentioning

confidence: 53%

“…Although expression of pIgR is constitutive, it also can be modulated by pro-inflammatory cytokines such as TNF-α (Asano and Komiyama 2011).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Intermittent fasting favored the resolution of Salmonella typhimurium infection in middle-aged BALB/c mice

Campos-Rodrı́guez

Godínez‐Victoria

Reyna-Garfias

et al. 2016

AGE

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“…PIGR is synthesized, delivered to basolateral plasma membranes and bound by polymeric IgA or IgM in secretory epithelia (7,10). PIGR is a type I transmembranous glycoprotein with extracellular, transmembranous and intracellular domains.…”

Section: Resultsmentioning

confidence: 99%

Epidermal polymeric immunoglobulin receptors: leads from intraepidermal neutrophilic IgA dermatosis‐type IgA pemphigus

Tsuchisaka

Ishii

Hamada

et al. 2015

Experimental Dermatology

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In this study, we attempted to identify unknown autoantigen for intraepidermal neutrophilic IgA dermatosis-type IgA pemphigus by novel IgA-specific immunoprecipitation. Massspectrometry study identified polymeric immunoglobulin receptor (PIGR) as the candidate protein, and we confirmed that PIGR expressed in both epidermis and cultured keratinocytes. Eukaryotic recombinant protein of PIGR expressed in COS7 cells was reacted with both patient and normal sera, indicating that PIGR binds physiologically to IgA. To detect antigen-specific binding by IgA autoantibodies, we performed several experiments using deglycosylated PIGR and F(ab) 2 fragments from patient sera. However, these analyses suggested that patient IgA bound physiologically, but not immunologically, to PIGR. Nevertheless, our study provided two important insights. Newly developed IgAimmunoprecipitation system should be a useful tool in the future study of identification of antigens for IgA autoantibodies. Detection of epidermal PIGR in this study confirmed previous results and indicated possible immunological role of PIGR in epidermis.

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“…Interplay between salivary epithelial cells and plasma cells in the salivary gland stroma is necessary for sIgA secretion (16). In plasma cells, two IgA molecules are dimerized with the J-chain and secreted; the secreted dimeric IgA (dIgA) is captured by the polymeric immunoglobulin receptor (pIgR) expressed on the basolateral membrane of salivary acinic or ductal cells.…”

Section: Figmentioning

confidence: 99%

Effects of bittern water on cariogenic bacteria and saliva secretion

et al. 2017

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The effects of bittern water (BW),obtained from the ocean floor, on cariogenic bacteria and saliva secretion were examined. Streptococcus mutans was mixed with BW for 1, 3, 5, 10, and 20 min to explore the bactericidal effects of BW against cariogenic bacteria. Bacterial viability was calculated by counting the number of colony-forming units on Brain Heart Infusion agar plates. The results indicated a bacterial viability of more than 35% even after 20 min of incubation. Subsequently, the effects of BW on saliva secretion and the salivary concentration of secretory IgA (sIgA) were examined. Gargling with BW significantly augmented saliva secretion. Although the sIgA concentration was reduced, the total sIgA secreted into saliva was increased significantly. Our findings indicate that the use of BW may be a new strategy for the treatment of various oral diseases, including dry mouth.

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Polymeric immunoglobulin receptor

Cited by 98 publications

References 80 publications

Intermittent fasting favored the resolution of Salmonella typhimurium infection in middle-aged BALB/c mice

Intermittent fasting favored the resolution of Salmonella typhimurium infection in middle-aged BALB/c mice

Epidermal polymeric immunoglobulin receptors: leads from intraepidermal neutrophilic IgA dermatosis‐type IgA pemphigus

Effects of bittern water on cariogenic bacteria and saliva secretion

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