The Occurrence and Treatment of Neurologic Changes in Pernicious Anemia

Goldhamer, S. M.

doi:10.1001/jama.1934.02750480001001

Cited by 29 publications

(4 citation statements)

References 13 publications

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“…Exactly which psychiatric effects of hypovitaminosis B 12 could be reversed? The list of symptoms that were reported to abate with vitamin B 12 replacement therapy from a combined series of 371 patients from several studies 18–39 are as follows:…”

Section: Specific Psychiatric Conditions That Were Noted To Improvementioning

confidence: 99%

“…Many of these reports between 1928 and 1960 18–39 were descriptive and dealt with a variety of related issues. Table 1 is a compilation of specific instances of improvement in a patient's status during this era, constructed with two goals: to suggest the commonality of symptoms among these studies, and to illustrate each symptom's relative reported frequency.…”

Section: Specific Psychiatric Conditions That Were Noted To Improvementioning

confidence: 99%

“…There was not one patient described whose dementia improved with vitamin B 12 therapy, yet already this literature 18–39 made repeated reference to dementia as the probable outcome of chronically unrecognized and untreated vitamin B 12 deficiency. The clinical implication was simply that demented patients had progressed too far for recovery.…”

Section: Specific Psychiatric Conditions That Were Noted To Improvementioning

confidence: 99%

See 2 more Smart Citations

What are the Psychiatric Manifestations of Vitamin B₁₂ Deficiency?

Hector¹,

Burton²

1988

J American Geriatrics Society

145

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Psychiatric symptoms attributable to vitamin B12 deficiency have been described for decades. The earlier reports are for the most part in accord with more recent ones, despite being diagnostically less specific in psychiatric and hematologic terms. These symptoms seem to fall into several clinically separate categories: slow cerebration; confusion; memory changes; delirium, with or without hallucinations and/or delusions; depression; acute psychotic states; and (more rarely) reversible manic and schizophreniform states. While there still remain abundant hematologic, psychiatric, neurologic, or nutritional reasons for obtaining a serum vitamin B12 level, its use in the investigation of the etiology of a patient's dementia seems unjustified. However, acute or subacute changes in a demented patient's mental status, specifically a clouding of their consciousness, may make such testing advisable as part of the complete workup of their delirium regardless of a normal hematologic picture.

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Section: Specific Psychiatric Conditions That Were Noted To Improvementioning

confidence: 99%

Section: Specific Psychiatric Conditions That Were Noted To Improvementioning

confidence: 99%

Section: Specific Psychiatric Conditions That Were Noted To Improvementioning

confidence: 99%

See 1 more Smart Citation

What are the Psychiatric Manifestations of Vitamin B₁₂ Deficiency?

Hector¹,

Burton²

1988

J American Geriatrics Society

145

View full text Add to dashboard Cite

show abstract

“…The neurologic disorders associated with pernicious anemia were well described in the literature of the late nineteenth century and the first decade of this century [1][2][3][4][5][6][7]. Certain limitations including uncertainty as to underlying diagnosis and problems in evaluating therapy are noted in previous studies.…”

Section: Introductionmentioning

confidence: 99%