The Obstetrician Gynecologist’s role in the screening of infants at risk of severe plagiocephaly: Prevalence and risk factors

Maniglio, Paolo; Noventa, Marco; Tartaglia, S.; Marco, Petracca; Bonito, Marco; Ricciardi, Enzo; Ambrosini, Guido; Buzzaccarini, Giovanni; Laganà, Antonio Simone

doi:10.1016/j.ejogrb.2022.03.011

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…First, to systemically assess the correlation between hyperglycemia in pregnancy and craniofacial malformation, we employed a meta-analysis ( Gurevitch et al, 2018 ) at the four typical steps (identification, screening, eligibility, and inclusion) on the literature available in PubMed, Embase, Cochrane Library and Web of Science databases ( Figure 1A ). In the final included studies ( Janssen et al, 1996 ; Moore et al, 2000 ; Åberg et al, 2001 ; Stott-Miller et al, 2010 ; Balsells et al, 2012 ; Trindade-Suedam et al, 2016 ; Yang et al, 2019 ; Tinker et al, 2020 ; Maniglio et al, 2022 ; Zhang et al, 2022 ), we selected all types of deformities involved in the development of head and facial bones, such as orofacial clefts, cleft lip and/or palate, and positional plagiocephaly. In the context of type I or II or gestational diabetes ( Figure 1B ).…”

Section: Resultsmentioning

confidence: 99%

Baicalin administration could rescue high glucose-induced craniofacial skeleton malformation by regulating neural crest development

Lu,

Luo,

Sun

et al. 2024

Front. Pharmacol.

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Hyperglycemia in pregnancy can increase the risk of congenital disorders, but little is known about craniofacial skeleton malformation and its corresponding medication. Our study first used meta-analysis to review the previous findings. Second, baicalin, an antioxidant, was chosen to counteract high glucose-induced craniofacial skeleton malformation. Its effectiveness was then tested by exposing chicken embryos to a combination of high glucose (HG, 50 mM) and 6 μM baicalin. Third, whole-mount immunofluorescence staining and in situ hybridization revealed that baicalin administration could reverse HG-inhibited neural crest cells (NCC) delamination and migration through upregulating the expression of Pax7 and Foxd3, and mitigate the disordered epithelial-mesenchymal transition (EMT) process by regulating corresponding adhesion molecules and transcription factors (i.e., E-cadherin, N-cadherin, Cadherin 6B, Slug and Msx1). Finally, through bioinformatic analysis and cellular thermal shift assay, we identified the AKR1B1 gene as a potential target. In summary, these findings suggest that baicalin could be used as a therapeutic agent for high glucose-induced craniofacial skeleton malformation.

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Section: Resultsmentioning

confidence: 99%

Baicalin administration could rescue high glucose-induced craniofacial skeleton malformation by regulating neural crest development

Lu,

Luo,

Sun

et al. 2024

Front. Pharmacol.

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“…Gender: Four studies demonstrated a significant association between male gender and DP [35, 38, 41, 45], one reported borderline significance [39], and seven reported no association between male gender and DP [9, 30–32, 34, 37, 40]. Of these 12 studies, six studies [31, 32, 35, 38, 41, 45] reported odds ratios which were analysed by meta-analysis, which revealed significant inter-study heterogeneity (I 2 , 68.5%; Q, 15.89; df, 6).…”

Section: Resultsmentioning

confidence: 99%

“…Maternal age: Three studies demonstrated an association between maternal age and DP [30, 34, 45]. Of these three, one study reported that mothers of infants with a diagnosis of DP were older than mothers of infants without DP (36.2; 95% CI 27.04-45.37 vs 34.0; 95% CI 22.89-45.12, respectively; P<0.01) [34]. Three further studies reported no significant association [32, 40, 42].…”

Section: Resultsmentioning

confidence: 99%

Non-obstetric risk factors for deformational plagiocephaly: A systematic review and meta-analysis

Hillyar,

Bishop,

Bell-Davies

et al. 2023

Preprint

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Plagiocephaly is defined as asymmetrical distortion of the skull resulting in an oblique trapezoid or parallelogram head shape. In the absence of skull growth restriction due to craniosynostosis, deformational plagiocephaly (DP) is caused by deformational forces acting on one side of the back of the head which distorts the normal symmetry of the skull. The aims of this systematic review and meta-analysis were to critically assess the evidence for non-obstetric risk factors for DP and to make evidence-based recommendations for reducing the prevalence of DP. A search of PubMed and Web of Science was performed covering 21 August 2010 to 21 August 2022. The searches yielded 159 articles, of which 18 articles were eligible for inclusion in this study. 43 non-obstetric factors were identified. Of these, a total of 17 factors were associated with DP. With the notable exceptions of maternal age, mechanical ventilation and tummy time, these associations were either supported by non-conflicting evidence or a meta-analysis that resolved conflicting evidence into a significant association. Thirteen factors had significant odds ratios that ranged from 1.10 (mechanical ventilation) to 7.15 (insufficient vitamin D intake). Of the five factors assessed by meta-analysis (male gender, reaching fewer motor milestones by six months of age, maternal education level, head position preference, sleeping position), only one (male gender) was associated with significant inter-study heterogeneity. No evidence of publication bias was detected. In summary, this study provides the most comprehensive meta-analytic assessment of non-obstetric factors associated with DP published to date. It provides 13 evidence-based recommendations which can be adopted by healthcare systems globally, to reduce the prevalence of DP and its impact on child development.

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“…Prenatal care is paramount for early diagnosis and management of several obstetric conditions [42][43][44]. An antenatal diagnosis of bilobed placenta may minimize pre-and postpartum complications.…”

Section: Discussionmentioning

confidence: 99%

Bilobed placenta and management choices: liture review and two cases studies

Calagna¹,

Polito²,

Schiattarella³

et al. 2023

It Journ Gyn Obs

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The Obstetrician Gynecologist’s role in the screening of infants at risk of severe plagiocephaly: Prevalence and risk factors

Cited by 4 publications

References 35 publications

Baicalin administration could rescue high glucose-induced craniofacial skeleton malformation by regulating neural crest development

Baicalin administration could rescue high glucose-induced craniofacial skeleton malformation by regulating neural crest development

Non-obstetric risk factors for deformational plagiocephaly: A systematic review and meta-analysis

Bilobed placenta and management choices: liture review and two cases studies

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