Baicalin administration could rescue high glucose-induced craniofacial skeleton malformation by regulating neural crest development
Jia-Qi Lu,
Zhi-Yan Luo,
Chengyang Sun
et al.
Abstract:Hyperglycemia in pregnancy can increase the risk of congenital disorders, but little is known about craniofacial skeleton malformation and its corresponding medication. Our study first used meta-analysis to review the previous findings. Second, baicalin, an antioxidant, was chosen to counteract high glucose-induced craniofacial skeleton malformation. Its effectiveness was then tested by exposing chicken embryos to a combination of high glucose (HG, 50 mM) and 6 μM baicalin. Third, whole-mount immunofluorescenc… Show more
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