The Obstetric Importance of Obesity and “Benign” Glycosuria in Prediagnosis Diabetes

Pomeranze, Julius; Stone, Michael E.; KING, EDWARD J.

doi:10.1097/00006250-195902000-00007

Cited by 18 publications

(3 citation statements)

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“…Similar observations were made by a number of authors in the 1940s and 1950s (9-15). Pomeranze et a1 (16) found that in 643 women with established diabetes mellitus, the perinatal mortality rate was 24-30% in the 5 years immediately preceding the diagnosis of diabetes, and 12-16% in the period 5-20 years before this diagnosis. The current condition of gestational diabetes was first suggested by Jackson (17).…”

Section: Discussionmentioning

confidence: 98%

Identification and Treatment of Women With Hyperglycaemia Diagnosed During Pregnancy Can Significantly Reduce Perinatal Mortality Rates

Beischer

Wein

Sheedy

et al. 1997

Obstetrical & Gynecological Survey

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Summup:We wished to determine whether gestational diabetes was associated with an increased perinatal mortality rate, and to investigate the cause for the observed increase in the incidence of gestational diabetes. We therefore reviewed the results of glucose tolerance tests and pregnancy outcome in 116,303 pregnancies, 1971-1994, at the Mercy Hospital for Women. The main outcome measurements were the presence or absence of gestational diabetes, and perinatal mortality. Over the entire period of the study, gestational diabetes was associated with an increased risk of perinatal mortality (Mantel-Haenszel adjusted odds ratio 1.53, 95% CI 1.13-2.06, p=0.0069). Women with gestational diabetes that was only diagnosed retrospectively had a higher perinatal mortality rate than their contemporaries with normal glucose tolerance (OR 2.31,95% CI 1.37-3.91, p=0.0025). Women in whom a glucose tolerance test was not performed continued to have a higher perinatal mortality rate than women who were tested (adjusted OR 2.21,95% CI 1.56-3.12, p

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Section: Discussionmentioning

confidence: 98%

Identification and Treatment of Women With Hyperglycaemia Diagnosed During Pregnancy Can Significantly Reduce Perinatal Mortality Rates

Beischer

Wein

Sheedy

et al. 1997

Obstetrical & Gynecological Survey

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“…Unfortunately, more than one half of the diabetic patients are unaware of the genetic background of their families; 3 accordingly, it is most desirable to be able to recognize the metabolic disorder at a very early time, in the light of possible prophylactic measures. Though the means of diagnosing the "prediabetic state" are lacking at present, 4 ' 5 nevertheless it is suspect in those individuals with parents who are both diabetic, 6 given birth to abnormally large babies 7 " 20 and who present other obstetrical complications such as frequent abortions, 21 " 27 glucosurias, 28 ' 28 and exaggerated weight gain during pregnancy, 30 " 33 polyhydramnios or infants with serious congenital malformations. 34 In some of these reports it was not possible to determine whether the abnormalities were associated with prediabetes or with early undetected diabetes or both.…”

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confidence: 99%

A Triamcinolone-glucose Tolerance Test in the Early Diagnosis of Diabetes

Navarrete¹,

Torres²

1965

Diabetes

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A glucose tolerance test with the prior administration of triamcinolone (8 mg. at eleven and at one hour preceding glucose) was performed in two groups, (1) a control group of 163 normal individuals having no diabetic antecedents; and (2) a group of 301 “clinically prediabetic” patients so classified on obstetrical grounds orbecause both parents were diabetic, with a previously normal glucose tolerance test. Abnormal triamcinolone curves were found in 1.8 per cent of the control group, an additional 1.8 per cent were “suspicious,” contrasting with 80 per cent abnormal and 11.6 per cent “suspicious” curves in the clinically prediabetic group. A comparison of this test with the standard glucose tolerance, the tolbutamide or the glucose-cortisone test, reveals that the triamcinolone test had a higher correlation with the clinical findings; also, the disadvantages attributed to the glucose-cortisone test did not occur.

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“…Jackson and Woolf (1957) stated that latent or pre-diabetes is a very common cause of unexplained stillbirths, and that pre-diabetes is now a well-established entity. Pomeranze, Stone and King (1959) believe that the problem of diabetes in the sub-threshold state is not merely an academic one, and proper recognition may bring about increased foetal salvage. Rome (1960) has stressed that it is the diabetics diagnosed during pregnancy that have the lowest perinatal wastage, and that such patients often lose the condition within six months of confinement, although it may reappear in subsequent pregnancies.…”

mentioning

confidence: 99%