A Triamcinolone-glucose Tolerance Test in the Early Diagnosis of Diabetes

Abstract

A glucose tolerance test with the prior administration of triamcinolone (8 mg. at eleven and at one hour preceding glucose) was performed in two groups, (1) a control group of 163 normal individuals having no diabetic antecedents; and (2) a group of 301 “clinically prediabetic” patients so classified on obstetrical grounds orbecause both parents were diabetic, with a previously normal glucose tolerance test. Abnormal triamcinolone curves were found in 1.8 per cent of the control group, an additional 1.8 per cent were “suspicious,” contrasting with 80 per cent abnormal and 11.6 per cent “suspicious” curves in the clinically prediabetic group. A comparison of this test with the standard glucose tolerance, the tolbutamide or the glucose-cortisone test, reveals that the triamcinolone test had a higher correlation with the clinical findings; also, the disadvantages attributed to the glucose-cortisone test did not occur.

Triamcinolone Provocative Test in Offspring of Two Diabetic Parents

“…2 The cortisone glucose tolerance test (CGTT) Positive-The two-hour figure at or above 140 mg. 3 The triamcinolone glucose tolerance test (TGTT) Abnormal-Two figures at or above 115, 170, 135 and 120 mg. at o, 1, 2 and 3 hrs., respectively. Suspicious-• Only one altered figure.…”

“…per kilogram as established previously. 2 A cortisone glucose tolerance test, following the Fajans and Conn 3 method and interpretation was also performed in nineteen cases.…”

“…Suspicious-• Only one altered figure. 2 In both groups a TGTT was performed. In only nineteen cases was it possible to perform a comparative study of cortisone versus triamcinolone tests.…”

Hyperplasia of Endometrium and Glucose Metabolic Disorder

“…If the glucose tolerance test was normal, she was submitted to a TGTT. 10 A 3000-calorie diet was prescribed for at least 3 days prior to both types of tests. For the SGTT, a glucose load of 1.75 gm./kg.…”

Triamcinolone-augmented glucose tolerance in non-diabetic patients with chronic pancreatitis

“…test (GTT). A study was therefore designed to assess the diagnostic value of an oral GTT augmented with triamcinolone (Navarette and Torres, 1965) in a group of non-diabetic patients with chronic pancreatitis, with reference to their insulin secretory capacity.…”