The number of optic neuritis attacks is a potential confounder when comparing patients with NMO vs. controls by voxel-based neuroimaging analysis

Catasús, Carlos Sánchez; Cabrera-Gómez, José Antonio; Melián, William Almaguer; Bosch-Bayard, Jorge; Rodríguez‐Rojas, Rafael; Valdés‐Sosa, Pedro A.

doi:10.1177/0284185115610935

Cited by 2 publications

(3 citation statements)

References 23 publications

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“…In patients with MS, a reduction in cerebral perfusion was observed in perfusion‐weighted MRI (Law et al 2004; Adhya et al 2006; Varga et al 2009; Papadaki et al 2012; D'Haeseleer et al 2013). Alterations in perfusion have also been reported in NMO, and these changes were suggested to play an important role in the pathophysiology (Sanchez‐Catasus et al 2013; Sanchez‐Catasus et al 2016). There were ten patients with NMOSD, two patients with anti‐MOG‐IgG and one patient with MS in this study.…”

Section: Discussionmentioning

confidence: 98%

Peripapillary and parafoveal microvascular changes in eyes with optic neuritis and their fellow eyes measured by optical coherence tomography angiography: an Exploratory Study

Lee

Park

et al. 2020

Acta Ophthalmologica

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This study aimed to evaluate parafoveal and peripapillary microvascular alterations in eyes with optic neuritis (ON) along with their fellow eyes compared to healthy control eyes using optical coherence tomography angiography (OCT-A). Methods: We included 31 ON-affected eyes and 31 fellow eyes of 31 patients who had experienced unilateral ON and 33 eyes of 33 healthy controls in this exploratory retrospective cross-sectional study. Optical coherence tomography angiography (OCT-A) was used to generate microvascular structural images and quantify the vessel density of the superficial retinal capillary plexus (SRCP), the deep retinal capillary plexus (DRCP) and radial peripapillary capillary (RPC) segments. We used the Kruskal-Wallis test for the comparison of OCT-A results between the three groups and generalized estimating equation models for the pairwise comparisons. Results: There were significant differences of SRCP (p = 0.0003) and RPC segment (p < 0.0001) vessel densities between the three groups. Specifically, there was a reduction in parafoveal and peripapillary vessel density in the ONaffected eyes compared to fellow eyes (SRCP, estimates, À1.97, 95% confidence interval [CI], À3.

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Section: Discussionmentioning

confidence: 98%

Peripapillary and parafoveal microvascular changes in eyes with optic neuritis and their fellow eyes measured by optical coherence tomography angiography: an Exploratory Study

Lee

Park

et al. 2020

Acta Ophthalmologica

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“…Therefore, we believe that the disappearance of significant CBF differences in several brain regions after GMV correction indicates that the altered CBF in these regions is possibly caused by GMV changes. However, the number of optic neuritis attacks may be a potential confounder, so limited reproducibility across VBM studies has been shown in regard to NMO ( 16 ). It should be noted that the relationship between CBF and GMV is rather complex and needs to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

“…Over the past few decades, brain MRI techniques have greatly improved our understanding of the brain damage in these two disorders. In addition to the extensive white matter damage, both disorders have shown the involvement of gray matter ( 6 – 16 ). However, the absence of cortical lesions and atrophy or deep gray matter abnormalities has also been reported in NMO or NMO spectrum disorder (NMOSD) with aquaporin-4 antibody-positive (AQP4 Ab-positive) ( 17 – 20 ).…”

Section: Introductionmentioning

confidence: 99%

Cerebral Blood Flow Changes in Multiple Sclerosis and Neuromyelitis Optica and Their Correlations With Clinical Disability

et al. 2018

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Distinguishing relapsing-remitting multiple sclerosis (RRMS) and neuromyelitis optica (NMO) is clinically important because they differ in prognosis and treatment. This study aimed to identify perfusion abnormalities in RRMS and NMO and their correlations with gray matter volume (GMV) atrophy and clinical parameters. Structural and arterial spin labeling MRI scans were performed in 39 RRMS patients, 62 NMO patients, and 73 healthy controls. The gray matter cerebral blood flow (CBF) values were voxel-wisely compared among the three groups with and without GMV correction. The regional CBF changes were correlated with the Expanded Disability Status Scale scores in the corresponding patient groups. Although multiple brain regions showed CBF differences among the three groups without GMV correction, only three of these regions remained significant after GMV correction. Specifically, both the RRMS and NMO groups showed reduced CBF in the occipital cortex and increased CBF in the right putamen compared to the control group. The RRMS group had increased CBF only in the medial prefrontal cortex compared to the other two groups. The occipital CBF was negatively correlated with clinical disability in the NMO group; however, the CBF in the right putamen was positively correlated with clinical disability in both patient groups. These findings suggest that there are perfusion alterations independent of GMV atrophy in RRMS and NMO patients. The regional CBF in the occipital cortex and putamen could be used as imaging features to objectively assess clinical disability in these patients.

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The number of optic neuritis attacks is a potential confounder when comparing patients with NMO vs. controls by voxel-based neuroimaging analysis

Abstract: These findings highlight the confounding effect of the number of ON attacks, providing a new methodological insight that could explain the limited reproducibility of previous VBM studies in NMO.

Cited by 2 publications

References 23 publications

Peripapillary and parafoveal microvascular changes in eyes with optic neuritis and their fellow eyes measured by optical coherence tomography angiography: an Exploratory Study

Peripapillary and parafoveal microvascular changes in eyes with optic neuritis and their fellow eyes measured by optical coherence tomography angiography: an Exploratory Study

Cerebral Blood Flow Changes in Multiple Sclerosis and Neuromyelitis Optica and Their Correlations With Clinical Disability

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