The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age

Gregg, Randal K.; Smith, C. F. C.; Clark, Fiona; Dunnion, Debbie; Khan, Naeem; Chakraverty, Ronjon; Nayak, Laxman; Moss, Paul

doi:10.1111/j.1365-2249.2005.02798.x

Cited by 347 publications

(261 citation statements)

References 27 publications

Supporting

Mentioning

206

Contrasting

Unclassified

Order By: Relevance

“…This is paralleled by an increase in WBC count while further WBC subpopulation analysis is poorly feasible considering the wide variability of measurements, the small number of subjects and the number of potential confounding factors. 41 In conclusion, while our study has limitations, we note that the solid nutritional evaluation included in the study design minimized the impact of confounding factors that burden similar studies. 42 Our data suggest that Spirulina may counteract anemia and immunosenescence.…”

Section: Discussionmentioning

confidence: 99%

The effects of Spirulina on anemia and immune function in senior citizens

et al. 2011

View full text Add to dashboard Cite

Anemia and immunological dysfunction (i.e. immunosenescence) are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena. Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects. We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia. We enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases. Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study. Complete cell count (CCC) and indoleamine 2,3-dioxygenase (IDO) enzyme activity, as a sign of immune function, were determined at baseline and weeks 6 and 12 of supplementation. Thirty study participants completed the entire study and the data obtained were analyzed. Over the 12-week study period, there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes. In addition, mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants. Older women appeared to benefit more rapidly from Spirulina supplements. Similarly, the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation. Spirulina may ameliorate anemia and immunosenescence in older subjects. We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials.

show abstract

Section: Discussionmentioning

confidence: 99%

The effects of Spirulina on anemia and immune function in senior citizens

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Immunohistochemical analysis also verified a dramatic increase of FoxP3 ϩ cells and inflammatory cells infiltrating in the liver of CSHB patients. Increased Treg with age has recently been reported (44). Therefore, we analyzed the circulating Treg frequency of 10 healthy subjects age 40 -55 (47.3 Ϯ 5.6) years old from 42 healthy controls in our study.…”

Section: Discussionmentioning

confidence: 99%

Circulating and Liver Resident CD4+CD25+ Regulatory T Cells Actively Influence the Antiviral Immune Response and Disease Progression in Patients with Hepatitis B

Jin

et al. 2006

The Journal of Immunology

403

363

View full text Add to dashboard Cite

CD4+CD25+ regulatory T cells (Treg) have been shown to maintain immune tolerance against self and foreign Ags, but their role in persistent viral infection has not been well-defined. In this study, we investigated whether and where CD4+CD25+ Treg contribute to the development of chronic hepatitis B (CHB). One hundred twenty-one patients were enrolled, including 16 patients with acute hepatitis B, 76 with CHB, and 29 with chronic severe hepatitis B. We demonstrated that in chronic severe hepatitis B patients, the frequencies of CD4+CD25+ Treg in both PBMC and liver-infiltrating lymphocytes were significantly increased and there was a dramatic increase of FoxP3+-cell and inflammatory cell infiltration in the liver compared with healthy controls. In CHB patients, circulating CD4+CD25+ Treg frequency significantly correlates with serum viral load. In acute hepatitis B patients, circulating CD4+CD25+ Treg frequency was initially low and with time, the profile reversed to exhibit an increased number of circulating Treg in the convalescent phase and restored to normal levels upon resolution. In PBMC taken from infected patients, depletion of CD4+CD25+ Treg led to an increase of IFN-γ production by HBV-Ag-stimulated PBMC. In addition, CD4+CD25+ Treg were capable of suppressing proliferation of autologous PBMC mediated by HBV Ags, which probably reflects the generation of HBV-Ag-specific Treg in circulation and in the liver of HBV-infected patients. Together, our findings suggest that CD4+CD25+ Treg play an active role not only in modulating effectors of immune response to HBV infection, but also in influencing the disease prognosis in patients with hepatitis B.

show abstract

“…[10][11][12] There have been some studies pointing to an increase in the proportion of CD25 regulatory T cells in the peripheral blood of aged BALB/c 13,14 and C57BL/6 mice 15,16 as well as in elderly people. [17][18][19][20][21] Such imbalance might contribute to the decreased immune functional activity and other peculiarities of the immune system in this age group. 4,5,[19][20][21][22][23] In addition, increased frequency of the CD4 Foxp3 Treg phenotype has been shown in aged C57BL/6 24 and in elderly people.…”

Section: Abstract: T-lymphocytes Aging Regulators T-lymphocytes Inmentioning

confidence: 99%

Abnormal phenotypic distribution of regulatory and effector T cells in octogenarian and nonagenarian women

Cruvinel

Júnior

Araújo

et al. 2015

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age

Abstract: SummaryAgeing is associated with evidence of immune deficiency and dysregulation. Key changes in the immune system with ageing include a progressive reduction in naive T cell output associated with thymic involution and peripheral expansion of oligoclonal memory T cells.

Cited by 347 publications

References 27 publications

The effects of Spirulina on anemia and immune function in senior citizens

The effects of Spirulina on anemia and immune function in senior citizens

Circulating and Liver Resident CD4+CD25+ Regulatory T Cells Actively Influence the Antiviral Immune Response and Disease Progression in Patients with Hepatitis B

Abnormal phenotypic distribution of regulatory and effector T cells in octogenarian and nonagenarian women

Contact Info

Product

Resources

About