The number of FoxP3-positive tumor-infiltrating lymphocytes in patients with synchronous bilateral breast cancer

Goto, Risa; Hirota, Yuko; Aruga, Tomoyuki; Horiguchi, Shinichiro; Miura, Sakiko; Nakamura, Seigo; Takimoto, Masafumi

doi:10.1007/s12282-020-01049-4

Cited by 5 publications

(3 citation statements)

References 24 publications

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“… 56 Goto et al found no significant difference in the number of FoxP3-positive tumor-infiltrating lymphocytes between right and left breast cancers in patients with synchronous bilateral breast cancer, where the tumors develop in the same host immune environment. 57 Chen et al reported that patients with synchronous head and neck squamous cell carcinoma (HNSCC) and esophageal squamous cell carcinoma (ESCC) had significant higher CD8+ TILs in HNSCC and ESCC than metachronous patients. Furthermore, the immunologic expression was significantly correlated between the HNSCC and ESCC in synchronous patients.…”

Section: Discussionmentioning

confidence: 99%

Immune suppressive microenvironment in brain metastatic non-small cell lung cancer: comprehensive immune microenvironment profiling of brain metastases versus paired primary lung tumors (GASTO 1060)

Hou

Sai

et al. 2022

OncoImmunology

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Lung cancer is one of the most common causes of brain metastases and is always associated with poor prognosis. We investigated the immunophenotypes of primary lung tumors and paired brain metastases, as well as immunophenotypes in the synchronous group (patients with brain metastases upon initial diagnosis) and metachronous group (patients developed brain metastases during the course of their disease). RNA sequencing of eighty-six samples from primary lung tumors and paired brain metastases of 43 patients was conducted to analyze the tumor immune microenvironment. Our data revealed that matched brain metastases compared with primary lung tumors exhibited reduced tumor infiltrating lymphocytes (TILs), a higher fraction of neutrophils infiltration, decreased scores of immune-related signatures, and a lower proportion of tumor microenvironment immune type I (high PD-L1/high CD8A) tumors. Additionally, we found a poor correlation of PD-L1 expression between paired brain metastases and primary lung tumors. In addition, gene set enrichment analysis (GSEA) showed that some gene sets associated with the immune response were enriched in the metachronous group, while other gene sets associated with differentiation and metastasis were enriched in the synchronous group in the primary lung tumors. Moreover, the tumor immune microenvironment between paired brain metastases and primary lung tumors displayed more differences in the metachronous group than in the synchronous group. Our work illustrates that brain metastatic tumors are more immunosuppressed than primary lung tumors, which may help guide immunotherapeutic strategies for NSCLC brain metastases.

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Section: Discussionmentioning

confidence: 99%

Immune suppressive microenvironment in brain metastatic non-small cell lung cancer: comprehensive immune microenvironment profiling of brain metastases versus paired primary lung tumors (GASTO 1060)

Hou

Sai

et al. 2022

OncoImmunology

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“…Foxp3 + may indirectly inhibit tumor-speci c T cells by releasing factors such as TGF-β and IL-10, exerting immunosuppressive functions and promoting immune escape of tumors. [37] The role of CD4 + T lymphocytes in the tumor microenvironment is unclear, and therefore, the prognostic value of CD4 + T lymphocytes in tumors is somewhat controversial. In our study, high CD4 + T expression is associated with increased rate of lymph node metastases, acting as a promoter of immune escape.…”

Section: Discussionmentioning

confidence: 99%

The role of systemic inflammatory response index (SIRI) and tumor-infiltrating lymphocytes (TILs) in the prognosis of patients with laryngeal squamous cell carcinoma

Zhang

Tang

Heng

et al. 2022

J Cancer Res Clin Oncol

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Systemic in ammatory response index (SIRI) values and tumor-in ltrating lymphocytes (TILs) are associated with the prognosis of various tumors. There is minimal evidence of those two as prognostic markers in laryngeal squamous cell carcinoma (LSCC). In this study, we aimed to examine the predictive value of SIRI and tumor-in ltrating CD3+/CD4+/CD8+T-cells in the prognosis of patients who underwent partial or total laryngectomy.

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“…Published studies regarding immune infiltration in sBBCs is scarce, if any. Analyzing samples of sBBCs from 23 patients, one study found that nuclear grade was significantly associated with the number of FoxP3 positive TILs 36 . In the current work, we analyzed immune infiltration on a large number of sBBCs and confirmed that BC subtype was a master driver of immunosurveillance in BCs.…”

Section: Discussionmentioning

confidence: 99%

Evolution of synchronous bilateral breast cancers provide insights into interactions between host, tumor and immunity

Hamy

Abecassis

Darrigues

et al. 2021

Preprint

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Synchronous bilateral breast cancer (sBBC) occurs after both breasts have been affected by the same germline genetics, reproductive life factors and environmental exposures for decades. It represents an opportunity to decipher the complex interplay between host, tumor, immune system and response to neoadjuvant chemotherapy (NAC). On a cohort of 17575 BCs treated between 2005 and 2012, sBBCs (n=404) were associated with less aggressive proliferative patterns and higher rates of luminal breast cancers (BCs) when compared with unilateral BCs (n=17171). The left and right tumors were concordant for the majority of clinical and pathological features. Tumor pairs of concordant BC subtype were more frequent than pairs of discordant BC subtype, with notably a particularly high frequency of pairs of luminal BCs. Intriguingly, both the levels of tumor infiltrating lymphocytes (TILs) and the response to NAC were modified by the subtype of the contralateral tumors. Whole exome sequencing and RNAseq analyses revealed that left and right tumors were independent from a somatic mutation and transcriptomic point of view, while primary tumors (PT) before NAC and specimens with residual disease (RD) after NAC were more closely related. The analysis of the TCR repertoire identified very little overlap between patients, while common clones were shared in bilateral tumors within each patient. After NAC, the TCR repertoire of RD was enriched and expanded with clones edited by the contralateral PT.

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The number of FoxP3-positive tumor-infiltrating lymphocytes in patients with synchronous bilateral breast cancer

Cited by 5 publications

References 24 publications

Immune suppressive microenvironment in brain metastatic non-small cell lung cancer: comprehensive immune microenvironment profiling of brain metastases versus paired primary lung tumors (GASTO 1060)

Immune suppressive microenvironment in brain metastatic non-small cell lung cancer: comprehensive immune microenvironment profiling of brain metastases versus paired primary lung tumors (GASTO 1060)

The role of systemic inflammatory response index (SIRI) and tumor-infiltrating lymphocytes (TILs) in the prognosis of patients with laryngeal squamous cell carcinoma

Evolution of synchronous bilateral breast cancers provide insights into interactions between host, tumor and immunity

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