The number and activity of CD3+TCR Vα7.2+CD161+ cells are increased in children with acute rheumatic fever

Özkaya, Mehmet Okan; Baykan, Ali; Çakır, Mustafa; Vural, Cagdas; Sunkak, Süleyman; Ünal, Ekrem; Eken, Ahmet

doi:10.1016/j.ijcard.2021.02.020

Cited by 4 publications

(5 citation statements)

References 47 publications

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“…Moreover, reduced CXCR3 expression observed on T cells during acute pharyngitis suggests that S. pyogenes infection promotes migration of CD4+ T cells from the blood. These data suggest that CD4+ T cell migration and activation of unconventional T cells may serve as an early marker of S. pyogenes immunity in humans 40,46 .…”

Section: Discussionmentioning

confidence: 77%

Immune signature of acute pharyngitis in a Streptococcus pyogenes human challenge trial

et al. 2022

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Streptococcus pyogenes causes at least 750 million infections and more than 500,000 deaths each year. No vaccine is currently available for S. pyogenes and the use of human challenge models offer unique and exciting opportunities to interrogate the immune response to infectious diseases. Here, we use high-dimensional flow cytometric analysis and multiplex cytokine and chemokine assays to study serial blood and saliva samples collected during the early immune response in human participants following challenge with S. pyogenes. We find an immune signature of experimental human pharyngitis characterised by: 1) elevation of serum IL-1Ra, IL-6, IFN-γ, IP-10 and IL-18; 2) increases in peripheral blood innate dendritic cell and monocyte populations; 3) reduced circulation of B cells and CD4+ T cell subsets (Th1, Th17, Treg, TFH) during the acute phase; and 4) activation of unconventional T cell subsets, γδTCR + Vδ2+ T cells and MAIT cells. These findings demonstrate that S. pyogenes infection generates a robust early immune response, which may be important for host protection. Together, these data will help advance research to establish correlates of immune protection and focus the evaluation of vaccines.

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Section: Discussionmentioning

confidence: 77%

Immune signature of acute pharyngitis in a Streptococcus pyogenes human challenge trial

et al. 2022

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“…In some patients, MAIT cells represented nearly 60% of IFNγ-producing T-cells 10 , and depletion of MAIT cells from peripheral blood mononuclear cells prior to stimulation with GAS reduced the production of IFNγ, IL-1β, IL-2 and TNF, which drive immunopathology during the STSS cytokine storm 110 . Similarly, MAIT cells are highly elevated in the blood of patients with active acute rheumatic fever (ARF) and in those who have recently been released from hospitalization due to ARF, compared with healthy individuals 111 . Additionally, MAIT cells from patients with ARF exhibit higher constitutive IFNγ and TNF production than those obtained from healthy individuals, which likely contributes to immunopathology 112,113 .…”

Section: Mait Cellsmentioning

confidence: 99%

Pathogenesis, epidemiology and control of Group A Streptococcus infection

et al. 2023

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Streptococcus pyogenes (Group A Streptococcus; GAS) is exquisitely adapted to the human host, resulting in asymptomatic infection, pharyngitis, pyoderma, scarlet fever or invasive diseases, with potential for triggering post-infection immune sequelae. GAS deploys a range of virulence determinants to allow colonization, dissemination within the host and transmission, disrupting both innate and adaptive immune responses to infection. Fluctuating global GAS epidemiology is characterized by the emergence of new GAS clones, often associated with the acquisition of new virulence or antimicrobial determinants that are better adapted to the infection niche or averting host immunity. The recent identification of clinical GAS isolates with reduced penicillin sensitivity and increasing macrolide resistance threatens both frontline and penicillin-adjunctive antibiotic treatment. The World Health Organization (WHO) has developed a GAS research and technology road Surface-bound virulence factors M protein. GAS is classified based on the sequence of the 5′ end of the gene encoding the M protein (emm). More than 220 emm genotypes have been identified 2 . The M protein is a dimeric coiled-coil fibrillar protein that extends from the bacterial cell wall 38 . It consists of a conserved Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author selfarchiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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“…One study reported that the number of CD3 + TCRVα7.2 + CD161 + cells in the peripheral blood of patients with acute and convalescent rheumatic fever increased signi cantly, and these cells could produce more IFN-γ, TNF-α, perforin, etc. 35 . It is well known that these factors can aggravate the progression of psoriasis 36 .…”

Section: Discussionmentioning

confidence: 99%

Mucosal-associated invariant T (MAIT) cell activation and correlation of CD69+ MAIT cell frequency with disease activity in patients with psoriasis

Qiao

Ding

Liu

et al. 2022

Preprint

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Mucosa-associated invariant T (MAIT) cells are innate lymphocytes that play a specific role in autoimmune diseases. In particular, the frequency and phenotype of MAIT cells in the pathogenesis of psoriasis is not fully understood. Our study examines the frequency and phenotype of MAIT cells sorted from peripheral blood mononuclear cells (PBMCs) obtained from 53 cases of patients and 44 healthy control.Compared with the healthy control group, the frequency of circulating CD3 + MAIT cells, CD3 + CD8 + MAIT cells, CD4 + CD69 + MAIT and CD8 + CD69 + MAIT cells in psoriasis patients was significantly increased (p < 0.05). While the proportion of CD3 + CD4 + MAIT cells was decreased. Correlations between IL-15 and PASI scores and activated MAIT cells revealed a potential role of MAIT cells in the development of psoriasis. IL-15 was positively correlated with both CD4 + CD69 + MAIT and CD8 + CD69 + MAIT cells. Activated CD3 + MAIT cells and activated CD8 + MAIT cells in patients' serum were both positively correlated with patients' PASI scores, while activated CD4 + MAIT cells and PASI scores were negatively correlated .Our results suggest that the abnormal phenotype of MAIT cells in patients with psoriasis parallels the progression of the disease. These abnormalities may lead to skin and systemic immune disorders in patients with psoriasis.

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The number and activity of CD3+TCR Vα7.2+CD161+ cells are increased in children with acute rheumatic fever

Cited by 4 publications

References 47 publications

Immune signature of acute pharyngitis in a Streptococcus pyogenes human challenge trial

Immune signature of acute pharyngitis in a Streptococcus pyogenes human challenge trial

Pathogenesis, epidemiology and control of Group A Streptococcus infection

Mucosal-associated invariant T (MAIT) cell activation and correlation of CD69+ MAIT cell frequency with disease activity in patients with psoriasis

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