The NRAMP1, VDR, TNF-α, ICAM1, TLR2 and TLR4 gene polymorphisms in Iranian patients with pulmonary tuberculosis: A case–control study

Jafari, Mohammad; Nasiri, Mohammad Reza; Sanaei, Roozbeh; Anoosheh, Saber; Farnia, Parissa; Sepanjnia, Adel; Tajik, Nader

doi:10.1016/j.meegid.2016.01.013

Cited by 42 publications

(30 citation statements)

References 53 publications

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“…These inconsistent results may result from the genetic heterogeneity between the studied participants or the potential difference in the involved M. TB strains. Several studies have researched the association between polymorphisms of TLR4 and TB (25,26). In the present study, no polymorphisms in TLR4 showed any association with PTB in the Chinese population.…”

Section: Discussioncontrasting

confidence: 49%

Evaluation of TLR2,TLR4, and TOLLIP polymorphisms for their role in tuberculosis susceptibility

Huang

Wang

et al. 2018

APMIS

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Previous studies indicated that single-nucleotide polymorphisms (SNPs) of genes coding for toll-like receptors (TLRs) and toll-interacting protein (TOLLIP) may be involved in the pathogenesis of pulmonary tuberculosis (PTB). This study was designed to investigate potential associations between the polymorphisms in TLR2, TLR4, and TOLLIP and susceptibility to latent tuberculosis infection (LTBI) or subsequent PTB in a Chinese Han population. A total of 209 PTB and 201 LTBI patients and 204 healthy control subjects (HCS) were enrolled in our study. We performed a logistic regression including sex and age as covariates to test the effect of genotype. Genotyping was conducted using the improved multiplex ligase detection reaction (iMLDR). Eleven markers in TLR2, TLR4, and TOLLIP were assessed. No significant association between polymorphisms of TLR2 and TLR4 with PTB or LTBI was detected. For TOLLIP, rs5743899 (p = 0.005, OR = 1.83, 95% CI: 1.20-2.80) CC genotype were risk factors for PTB progression. Moreover, rs5743867 under addictive (p = 0.005, OR = 1.54, 95% CI: 1.14-2.07) and recessive model (p = 0.004, OR = 1.86, 95% CI: 1.22-2.83) were also risk factors for PTB susceptibility. Our results indicate that polymorphisms in TOLLIP affected the risk of PTB disease.

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Section: Discussioncontrasting

confidence: 49%

Evaluation of TLR2,TLR4, and TOLLIP polymorphisms for their role in tuberculosis susceptibility

Huang

Wang

et al. 2018

APMIS

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“…No association has been found between NRAMP1 variants and susceptibility to pulmonary TB in the Moroccan population (El Baghdadi et al, 2003). This finding is in agreement with other results reported in Taiwanese, Thai and Iranian populations (Jafari et al, 2016;Liaw et al, 2002;Merza et al, 2009;Vejbaesya, Chierakul, Luangtrakool, & Sermduangprateep, 2007…”

Section: Natural Resistance-associated Macrophage Protein 1: Nramp1supporting

confidence: 94%

“…No association has been found between NRAMP1 variants and susceptibility to pulmonary TB in the Moroccan population (El Baghdadi et al., ). This finding is in agreement with other results reported in Taiwanese, Thai and Iranian populations (Jafari et al., ; Liaw et al., ; Merza et al., ; Vejbaesya, Chierakul, Luangtrakool, & Sermduangprateep, ). By contrast, NRAMP1 polymorphisms were found to be statistically more frequent in TB patients from a variety of ethnic populations, suggesting their potential role in the increased risk of contracting TB and the progression of the disease (Bellamy et al., ; Ben‐Selma, Harizi, Letaief, & Boukadida, ; van Crevel et al., ; Fernàndez‐Mestre, Takiff, Alcalá, & Zhenia, ; Liu et al., ; Nugraha & Anggraini, ; Ryu et al., ; Søborg et al., ; Stagas et al., ).…”

Section: Candidate Genes and The Risk Of Developing Tbsupporting

confidence: 93%

Current immunogenetic predisposition to tuberculosis in the Moroccan population

Qrafli

Najimi

Elaouad

et al. 2017

Int J Immunogenetics

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Tuberculosis (TB) is a serious infectious disease that kills approximately two million people per year, particularly in low- and middle-income countries. Numerous genetic epidemiology studies have been conducted of many ethnic groups worldwide and have highlighted the critical impact of the genetic environment on TB distribution. Many candidate genes associated with resistance or susceptibility to TB have been identified. In Morocco, where TB is still a major public health problem, various observations of clinical, microbiological and incidence distribution are heavily affected by genetic background and external environment. Morocco has almost the same clinical profile as do other North African countries, mainly the increase in more extrapulmonary than pulmonary forms of the diseases, when compared to European, Asian or American populations. In addition, a linkage analysis study that examined Moroccan TB patients identified a unique chromosome region that had a strong association with the risk of contracting TB. Other genes in the Moroccan population that were found to be associated seem to be involved predominantly in modulating the innate immunity. In this review, we appraise the major candidate genes that have been reported in Moroccan immunogenetic studies and discuss their updated role in TB, particularly during the first phase of the immune response to Mycobacterium tuberculosis (Mtb) infection.

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“…TNF locus, located in the MHC class III region and coding for an important multifunctional cytokine that triggers a cascade of inflammatory mediators, has been linked with an increase risk for TB. Two mutations in the promoter region of the TNF-α gene at positions -238 (G/A) and -308 (G/A) were associated with pulmonary TB in the Colombian population [87] , the former also confirmed for Iranian in two different studies [88,89] . Also, the susceptibility for a pulmonary tuberculosis infection was found to be associated with the TNF-α -857T/C genetic polymorphism in Asian populations [90] and, for a reduced risk, with the CD14 G(-1145)A and C(-159)T polymorphisms in Chinese Han population [91] .…”

Section: Pulmonary Tuberculosismentioning

confidence: 94%

HLA Loci and Respiratory Infectious Diseases

Spínola

2016

Journal of Respiratory Research

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The HLA system harbour a wide set of genes that plays an important role in the regulation and action of the immune system against invading pathogens, making them natural candidates for research on the genetic susceptibility for respiratory infections. Thus, along past decades, this topic has been subject to intense research and, consequently, several alleles of those loci have been implicated in the ability, more or less effective, to tackle and control invading pathogens in the respiratory system. Current editorial introduce, revise, summarize and comment the major advances in the role of HLA genes for the development of, and protection against, respiratory infectious disease. A general picture is drawn and new challenges on the field are relocated, especially those that might enlighten respiratory diseases aetiology and, thus, contribute in advances for diagnosis and treatment.

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The NRAMP1, VDR, TNF-α, ICAM1, TLR2 and TLR4 gene polymorphisms in Iranian patients with pulmonary tuberculosis: A case–control study

Cited by 42 publications

References 53 publications

Evaluation of TLR2,TLR4, and TOLLIP polymorphisms for their role in tuberculosis susceptibility

Evaluation of TLR2,TLR4, and TOLLIP polymorphisms for their role in tuberculosis susceptibility

Current immunogenetic predisposition to tuberculosis in the Moroccan population

HLA Loci and Respiratory Infectious Diseases

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