Evaluation of <scp>TLR</scp>2,<scp>TLR</scp>4, and <scp>TOLLIP</scp> polymorphisms for their role in tuberculosis susceptibility

Wu, Shouquan; Huang, Weiwei; Wang, Dan; Wang, Yu; Wang, Minggui; Zhang, Miaomiao; He, Jian‐Qing

doi:10.1111/apm.12855

Cited by 19 publications

(14 citation statements)

References 32 publications

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“…The discrepancies between the aforementioned results may be attributed to the different sample sizes and ethnicities [37]. Our results were also differing from our previous study [38], which demonstrated that polymorphisms in TOLLIP affected the risk of pulmonary TB. The different results may be due to the different study designs.…”

Section: Discussioncontrasting

confidence: 99%

Polymorphisms of TLR2, TLR4 and TOLLIP and tuberculosis in two independent studies

Liu

Chen

et al. 2020

Bioscience Reports

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Genetic polymorphisms for tuberculosis (TB) susceptibility has been researched by some studies, but few have studied multiple innate immunity genes associated with TB. Evidence suggests that the toll-like receptor 2, 4 (TLR2, TLR4) and toll interacting protein (TOLLIP) may be associated with TB susceptibility. In this self-validated study, we explored the association between common single nucleotide polymorphisms (SNPs) of TLR2, TLR4 and TOLLIP in the Chinese Han and Tibetan populations. A SNPscanTM method was used to genotype SNPs in the three genes. Multiple logistic regression adjusted by sex and age was used to detect the association between SNPs and TB. In TLR2, rs1898830 was associated with decreased risk against TB in the Chinese Han population, which was validated in the Tibetan population. In TLR4, rs11536889 was a protective factor for TB in the Tibetan population, but not in the Han population. Additionally, in the Tibetan population, we also found that the frequency of genotypes of TOLLIP rs11536889 differs significantly between TB patients and controls. We found rs1898830 in TLR2 was associated with TB susceptibility in both Chinese Han and Tibetan populations while rs11536889 in TLR4 and rs3750920 in TOLLIP were protective factors against TB in the Tibetan population.

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Section: Discussioncontrasting

confidence: 99%

Polymorphisms of TLR2, TLR4 and TOLLIP and tuberculosis in two independent studies

Liu

Chen

et al. 2020

Bioscience Reports

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“…The power of our study design was assessed by using the Power and Sample Size Calculation software 73 . We calculated the power for each SNPs under an allelic model as described previously 74 . The frequency of each SNP in the two cohorts was sufficient to provide reasonable power (>80%) to detect an allele/genotype effect with OR 2.0 or above (Table 7).…”

Section: Methodsmentioning

confidence: 99%

Polymorphisms of cytokine genes and tuberculosis in two independent studies

Wang

et al. 2019

Sci Rep

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Cytokine gene single nucleotide polymorphisms (SNPs) can influence cytokine levels, which may be associated with tuberculosis (TB) susceptibility. There is evidence that interleukin 1B (IL1B), tumor necrosis factor-alpha (TNF-alpha), and IL6 may be involved in the progression of TB. Using a self-validating case-control design, we selected eleven functional SNPs in IL1B , TNF and IL6 to detect their association with TB in Chinese Han and Tibetan populations. The associations between SNPs and TB were estimated by computing the odds ratios (ORs) and 95% confidence intervals (95% CI) using logistic regression analyses. We found that the IL1B rs16944 polymorphism was associated with decreased risk of TB in the two studies. The G allele at rs2069837 of IL6 was significantly more common in controls than in TB patients in the Han population. Moreover, TNF rs1799964 and rs1800630 were risk factors for susceptibility to TB, which were validated in the Chinese Tibetan population. In addition, TNF rs1799724 and rs1800629 were associated with TB, but only in the Tibetan population. In conclusion, SNPs of the IL1B and TNF gene were associated with TB susceptibility in Chinese Han and Tibetan populations. IL6 polymorphism may be considered as a protective factor for TB in the Chinese Han population, but not the Tibetan population.

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“…A total of 209 PTB and 356 close contacts of individuals with sputum-positive PTB were enrolled between 2013 and 2014. The selection of sample size was based on previous studies [21–23]. All of the participants were recruited from the West China Hospital of Sichuan University (Sichuan, China), and they are all genetically unrelated Chinese Han people.…”

Section: Methodsmentioning

confidence: 99%

Genetic Polymorphisms ofIFNGandIFNGR1with Latent Tuberculosis Infection

Liu

Wang

et al. 2019

Disease Markers

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Previous studies indicated that single-nucleotide polymorphisms (SNPs) of interferon gamma (IFNG) and IFNG receptor 1 (IFNGR1) may be involved in the pathogenesis of pulmonary tuberculosis (PTB) in different populations. In order to further explore the results in a Chinese Han population, this study was designed to investigate potential associations between the polymorphisms in IFNG and IFNGR1 and susceptibility to latent tuberculosis infection (LTBI) and/or PTB in a Chinese Han population. A total of 209 PTB, 173 LTBI, and 183 healthy control subjects (HCS) were enrolled in our study. Genotyping was conducted using an improved multiplex ligase detection reaction (iMLDR). We performed a logistic regression including sex and age as covariates to test the effect of alleles/genotypes on LTBI and/or TB. All six markers studied in IFNG and IFNGR1 conformed to the Hardy–Weinberg equilibrium (HWE). The IFNG rs1861494 was significantly associated with LTBI in recessive model, and the CC+CT genotype decreased risk of LTBI by 50% (P = 0.046, OR = 0.50, 95%CI: 0.25-0.99). The IFNGR1 rs2234711 was significantly associated with LTBI, and allele A increased the risk of LTBI by 55% (P = 0.047, OR = 1.55, 95%CI: 1.00-2.40). In the present study, we found that IFNG and IFNGR1 polymorphisms were associated with LTBI.

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Evaluation of TLR2,TLR4, and TOLLIP polymorphisms for their role in tuberculosis susceptibility

Cited by 19 publications

References 32 publications

Polymorphisms of TLR2, TLR4 and TOLLIP and tuberculosis in two independent studies

Polymorphisms of TLR2, TLR4 and TOLLIP and tuberculosis in two independent studies

Polymorphisms of cytokine genes and tuberculosis in two independent studies

Genetic Polymorphisms ofIFNGandIFNGR1with Latent Tuberculosis Infection

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