The novel inflammatory marker GlycA and the prevalence and progression of valvular and thoracic aortic calcification: The Multi-Ethnic Study of Atherosclerosis

Abstract

Background and aims: GlycA is a novel composite biomarker of systemic inflammation reflecting posttranslational glycosylation of acute phase reactants. GlycA has been associated with

The association of novel inflammatory marker GlycA and incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis (MESA)

“…BMI, physical activity, smoking, blood pressure, glucose, cholesterol)–health metrics which are also risk factors for AF [ 18 ]. Higher GlycA levels have been linked with subclinical atherosclerosis [ 30 , 33 , 34 ], incident CVD [ 19 – 22 ], and with heart failure with preserved ejection fraction [ 23 ]. In a prior MESA study comparing the predictive value of GlycA and other inflammatory biomarkers, GlycA had a significantly predictive value comparable to hsCRP, IL-6, and D-dimer, if not superior, for total death, CVD, chronic inflammatory-related severe hospitalization and death, and total cancer [ 21 ].…”

GlycA, a Novel Inflammatory Marker and Its Association With Peripheral Arterial Disease and Carotid Plaque: The Multi-Ethnic Study of Atherosclerosis

“…37 Several other studies have shown similar positive associations between GlycA and incident CVD, mortality, and cancer 4 and have shown that the relationship with CVD was stronger for GlycA than that reported for hsCRP 38 and is independent of hsCRP. 39 Despite the aforementioned established association of GlycA with incident CVD events 4 and with subclinical coronary and extra-coronary atherosclerosis, 20,21,40 the relationship of GlycA with subclinical and clinical PAD, specifically, had not been previously established. Although there are some common shared cardiovascular risk factors that promote atherosclerosis across various vascular beds, risk factors are not necessarily overlapping.…”

“…Sixth, we performed multiple tests and results may be due to chance; however, findings were consistent with our a priori hypotheses and with other studies that have established a link between GlycA and atherosclerosis. 20,21 Finally, MESA recruitment took place in the early 2000s, which limits the study's generalizability to current day where primary prevention therapies are more prevalent and are more widely used.…”

“…Despite the aforementioned established association of GlycA with incident CVD events 4 and with subclinical coronary and extra-coronary atherosclerosis, 20,21,40 the relationship of GlycA with subclinical and clinical PAD, specifically, had not been previously established. Although there are some common shared cardiovascular risk factors that promote atherosclerosis across various vascular beds, risk factors are not necessarily overlapping.…”

“…4 GlycA has also been shown to be associated with several measures of subclinical atherosclerosis, including prevalent coronary artery calcium 20 as well as prevalent calcification in the thoracic aorta and aortic valve. 21 However, the associations of GlycA with atherosclerotic disease specifically located in the peripheral arteries and carotid arteries have not yet been established. Despite many shared risk factors, risk factors for atherosclerosis across different vascular beds are not necessarily overlapping 22,23 and warrant further study.…”