The Normal Trichogram of the Adult

Barman, Julio M.; Astore, Ignacio; Pecoraro, Vicente

doi:10.1038/jid.1965.42

Cited by 126 publications

(78 citation statements)

References 5 publications

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“…[3][4][5] Recent clinical trials evaluating the efficacy of drugs for treating common balding have used sophisticated photographic techniques to quantify hair density. Such methods are noninvasive, but the equipment and personnel required are impractical for routine clinical practice.…”

Section: Resultsmentioning

confidence: 99%

Hair Density in African Americans

Sperling

1999

Arch Dermatol

125

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Section: Resultsmentioning

confidence: 99%

Hair Density in African Americans

Sperling

1999

Arch Dermatol

125

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“…For human scalp hair, topical E2 has long been used in the management of telogen effluvium and androgenetic alopecia, especially in women (29,58,275). Although this remains to be unequivocally demonstrated in vivo, E2 has been proposed to decrease the telogen rate and to prolong the anagen phase in human scalp skin, justifying the use of topical E2 in the management of hair loss characterized premature catagen entry, such as androgenetic alopecia and telogen effluvium (29,30,88,(275)(276)(277).…”

Section: Species-specific Differences In Estrogen Actions On Hair mentioning

confidence: 99%

The Hair Follicle as an Estrogen Target and Source

et al. 2006

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For many decades, androgens have dominated endocrine research in hair growth control. Androgen metabolism and the androgen receptor currently are the key targets for systemic, pharmacological hair growth control in clinical medicine. However, it has long been known that estrogens also profoundly alter hair follicle growth and cycling by binding to locally expressed high-affinity estrogen receptors (ERs). Besides altering the transcription of genes with estrogen-responsive elements, 17␤-estradiol (E2) also modifies androgen metabolism within distinct subunits of the pilosebaceous unit (i.e., hair follicle and sebaceous gland). The latter displays prominent aromatase activity, the key enzyme for androgen conversion to E2, and is both an estrogen source and target.Here, we chart the recent renaissance of estrogen research in hair research; explain why the hair follicle offers an ideal, clinically relevant test system for studying the role of sex steroids, their receptors, and interactions in neuroectodermal-mesodermal interaction systems in general; and illustrate how it can be exploited to identify novel functions and signaling cross talks of ER-mediated signaling. Emphasizing the long-underestimated complexity and species-, gender-, and site-dependence of E2-induced biological effects on the hair follicle, we explore targets for pharmacological intervention in clinically relevant hair cycle manipulation, ranging from androgenetic alopecia and hirsutism via telogen effluvium to chemotherapy-induced alopecia. While defining major open questions, unsolved clinical challenges, and particularly promising research avenues in this area, we argue that the time has come to pay estrogen-mediated signaling the full attention it deserves in future endocrinological therapy of common hair growth disorders. (Endocrine Reviews 27: 677-706, 2006)

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“…1 Like other organs hair also needs adequate nutrition as evidenced by its affect in various nutritional diseases. 4,5 Protein energy malnutrition in particular causes significant hair changes. 4,5 Besides this, various micronutrients have also been implicated as etiological factors of hair loss.…”

Section: Introductionmentioning

confidence: 99%

“…4,5 Protein energy malnutrition in particular causes significant hair changes. 4,5 Besides this, various micronutrients have also been implicated as etiological factors of hair loss. 6,7 Iron deficiency is the most common nutritional deficiency disorder of the world.…”

Section: Introductionmentioning

confidence: 99%

A Study of Serum Ferritin Level in Female Patient with Alopecia

Pradhan¹,

Rai²,

Paudel³

2018

J Coll Med Sci-Nepal

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Introduction: Total body iron store is an integral factor in the development of hair follicle. Numerous studies have been done seeking for the relationship between body iron store and various forms of chronic diffuse hair loss, with relatively contradictory findings in various reports in these studies. The main objective of this study is to find out if there is any association between total body iron store and various types of chronic diffuse hair loss in females in reproductive age. Materials and Methods: This is a hospital based case control study conducted in Nobel Medical College and Teaching Hospital, Biratnagar, Nepal. Sixty female patients of age group 15-50 years with chronic diffuse hair loss with equal number of age-and sexmatched controls were studied. Both of the study groups were evaluated for various parameters of iron status. Results: The mean value of serum ferritin in cases was significantly lower as compared to controls (p=0.018). Patients with alopecia areata (p=0.008) and androgenetic alopecia (p=0.021) had significantly lower serum ferritin, whereas there was no statistically significant difference in telogen effluvium and controls (p=0.857).The mean value of hemoglobin, hematocrit and mean corpuscular hemoglobin was found to be significantly lower in alopecia areata and androgenetic alopecia. However, there was no statistically significant difference in RBC indices of patients of telogen effluvium and controls. Conclusion: Diffuse chronic hair loss shows definite association with serum ferritin and various RBC indices in female of reproductive age group. Alopecia areata and androgenetic alopecia show major association with total body iron stores.Keywords: alopecia areata; androgenetic alopecia; serum ferritin; telogen effluvium. 117 2017 to 28 February 2018. Written consent was taken from all the study subjects before their inclusion in the study. The study comprised of 120 female patient of reproductive age group (15-50 years) presenting to the dermatology department of Nobel Medical College and Teaching Hospital, Biratnagar, of which 60 were case and 60 controls. The diagnosis of various types of alopecia was made on the basis of history and clinical examination. Androgenetic alopecia, telogen effluvium and alopecia areata were included in the study. Inclusion criteria for cases: all the consenting female patients of age group 15-50 years with chronic hair loss. Exclusion criteria for cases: Participants on iron, folic acid, vitamin B12, pregnancy in the preceding one year, undergoing major surgery, endocrine abnormalities, on medication for systemic disorders and acute inflammatory condition. Inclusion criteria for controls: the control group comprised of age and sex matched patients presenting to the dermatology department for some other dermatological abnormality not directly related to alopecia of iron deficiency.Exclusion criteria for controls: Participants on iron, folic acid, vitamin B12, pregnancy in the preceding one year, undergoing major surgery, endocrine abnormalitie...

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The Normal Trichogram of the Adult

Cited by 126 publications

References 5 publications

Hair Density in African Americans

Hair Density in African Americans

The Hair Follicle as an Estrogen Target and Source

A Study of Serum Ferritin Level in Female Patient with Alopecia

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