Introduction: Total body iron store is an integral factor in the development of hair follicle. Numerous studies have been done seeking for the relationship between body iron store and various forms of chronic diffuse hair loss, with relatively contradictory findings in various reports in these studies. The main objective of this study is to find out if there is any association between total body iron store and various types of chronic diffuse hair loss in females in reproductive age. Materials and Methods: This is a hospital based case control study conducted in Nobel Medical College and Teaching Hospital, Biratnagar, Nepal. Sixty female patients of age group 15-50 years with chronic diffuse hair loss with equal number of age-and sexmatched controls were studied. Both of the study groups were evaluated for various parameters of iron status. Results: The mean value of serum ferritin in cases was significantly lower as compared to controls (p=0.018). Patients with alopecia areata (p=0.008) and androgenetic alopecia (p=0.021) had significantly lower serum ferritin, whereas there was no statistically significant difference in telogen effluvium and controls (p=0.857).The mean value of hemoglobin, hematocrit and mean corpuscular hemoglobin was found to be significantly lower in alopecia areata and androgenetic alopecia. However, there was no statistically significant difference in RBC indices of patients of telogen effluvium and controls. Conclusion: Diffuse chronic hair loss shows definite association with serum ferritin and various RBC indices in female of reproductive age group. Alopecia areata and androgenetic alopecia show major association with total body iron stores.Keywords: alopecia areata; androgenetic alopecia; serum ferritin; telogen effluvium. 117 2017 to 28 February 2018. Written consent was taken from all the study subjects before their inclusion in the study. The study comprised of 120 female patient of reproductive age group (15-50 years) presenting to the dermatology department of Nobel Medical College and Teaching Hospital, Biratnagar, of which 60 were case and 60 controls. The diagnosis of various types of alopecia was made on the basis of history and clinical examination. Androgenetic alopecia, telogen effluvium and alopecia areata were included in the study. Inclusion criteria for cases: all the consenting female patients of age group 15-50 years with chronic hair loss. Exclusion criteria for cases: Participants on iron, folic acid, vitamin B12, pregnancy in the preceding one year, undergoing major surgery, endocrine abnormalities, on medication for systemic disorders and acute inflammatory condition. Inclusion criteria for controls: the control group comprised of age and sex matched patients presenting to the dermatology department for some other dermatological abnormality not directly related to alopecia of iron deficiency.Exclusion criteria for controls: Participants on iron, folic acid, vitamin B12, pregnancy in the preceding one year, undergoing major surgery, endocrine abnormalitie...
Introduction: Skin is the mirror of an internal disease, including the renal system. Chronic kidney disease presents with variety of skin diseases, which is caused either by kidney disease or by treatment modalities.Objective: To evaluate the revalence of various skin disease in patients with chronic renal disease and relation of various skin diseases with serum creatinine, blood urea, hemoglobin and number of hemodialysis cycle.Methodology: A cross-sectional analytical study was conducted in hundred patients of either sex, aged 18 years and above; with chronic kidney disease (stage V) admitted for dialysis in Nephrology department of Nobel Medical College and teaching hospital, Biratnagar, Nepal. The study groups were evaluated for various skin manifestation and parameters of renal function like blood urea and serum creatinine.Results: Among the total patients (n=100), 84 patients presented with complain of skin manifestation but on detail examination 97 patients had at least one skin disease. The causes leading to chronic kidney disease were found to be hypertension 58%, diabetes mellitus 49%, IgA nephropathy 7%, systemic lupus erythematosus 7% and glomerulonephritis 4%. Xerosis was the commonest skin disease encountered in these patients amounting to 71% among which 43 were hypertensive and 34 were diabetic. Xerosis was followed by pruritus (62%), pallor (54%), mucosal changes (39%), skin infection (36%), hair changes (34%), pigmentation (33%) and nail changes (29%). Serum creatinine showed statistically significant association with pruritus ( =0.030) and pigmentation ( =0.010), similarly blood urea showed significant association with pruritus ( =0.001). Similarly, number of dialysis cycle showed significant association with pigmentation of skin ( =<0.001).Conclusion: Chronic kidney disease is associated with variety of skin diseases. The commonest were xerosis and pruritus. Early detection and appropriate intervention can relieve and decrease suffering. BJHS 2018;3(2)6:468-474.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.