Abstract:Nonlinearity is a characteristic of complex biological regulatory networks that has implications ranging from therapy to control. To better understand its nature, we analyzed a suite of published Boolean network models, containing a variety of complex nonlinear interactions, using a probabilistic generalization of Boolean logic that George Boole himself had proposed. The continuous-nature of this formulation made the models amenable to Taylor decomposition that revealed their distinct layers of nonlinearity. A… Show more
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