The Nitric Oxide-Scavenging Properties of Ginkgo Biloba Extract EGb 761

Marcocci, Lucia; Maguire, John F.; Droy-Lefaix, Marie-Thérèse; Packer, Lester

doi:10.1006/bbrc.1994.1764

Cited by 901 publications

(487 citation statements)

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“…NO is a potentially toxic agent with a free radical character and therefore it is responsible for many physiologic and pathologic events [23]. The moderate NO scavenging activity was observed by NJE (12.2%, 20.6%, 35.3%, and 46.8% at NJE concentrations of 100, 250, 500, and 1000 mg/ml, respectively).…”

Section: No Radicalmentioning

confidence: 98%

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In Vitro Antioxidant and Free Radical Scavenging Activity of Nardostachys jatamansi DC.

Sharma

Singh

2012

Journal of Acupuncture and Meridian Studies

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In this study, the antioxidative potential of a hydroalcoholic extract of Nardostachys jatamansi (NJE) rhizomes was evaluated by various antioxidant assays, including antioxidant capacity by the phosphomolybdenum method, total antioxidant activity in linoleic acid emulsion systems, 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide, hydroxyl radicals, nitric oxide (NO) scavenging, metal chelating and reducing power activity. These various antioxidant activities were compared with standard antioxidants such as butylated hydroxytoluene, tocopherol, catechin, and L-ascorbic acid. Total phenolic and flavonoid content of NJE was also determined by a colorimetric method. The extract exhibited high reduction capability and powerful free radical scavenging, especially against DPPH and superoxide anions as well as a moderate effect on NO. Moreover, the peroxidation inhibiting activity of NJE was demonstrated in the linoleic acid emulsion system. The results obtained in the present study clearly established the antioxidative potency of NJE, which may account for some of the medical claims attributed to this plant.

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Section: No Radicalmentioning

confidence: 98%

“…The scavenging effect of NJE on NO was measured according to the method of Marcocci and colleagues [23]. Briefly, sodium nitroprusside (5 mM) in phosphate-buffered saline (PBS) (pH 7.4) was mixed with different concentrations of the test sample (100e1000 mg/ml) and incubated at 25 C for 150 minutes.…”

Section: No Scavenging Activitymentioning

confidence: 99%

In Vitro Antioxidant and Free Radical Scavenging Activity of Nardostachys jatamansi DC.

Sharma

Singh

2012

Journal of Acupuncture and Meridian Studies

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“…The scavenging activity against nitric oxide was determined with a method of Marcocci et al [33]. The procedure is based on the fact that, in solutions, nitroprusside ions spontaneously release nitric oxide, which is subsequently transformed into nitrite ions by atmospheric oxygen.…”

Section: Chemical Analysis Of the Samplesmentioning

confidence: 99%

The Application of Supercritical Carbon Dioxide and Ethanol for the Extraction of Phenolic Compounds from Chokeberry Pomace

et al. 2017

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Chokeberry (Aronia melanocarpa (Michx.) Elliot) is a fruit with exceptionally high levels of phenolic compounds which are accumulated mainly in the peel; hence, the majority remains in the leftovers after juice production. Extraction with the use of carbon dioxide in supercritical conditions was used to isolate phenolic compounds from the pomace. The effect of the process parameters (temperature; pressure; and the addition of ethanol) on the extraction yields and properties of the extracts was investigated. The anthocyanin and total phenolic compound content, as well as the scavenging activity against five selected radicals, were evaluated. The best results were acquired for 35 • C, 10 MPa, and 80% m/m ethanol addition, the yield of phenolic compounds was 1.52 g per 100 g of pomace. The amount of extracted phenolics and the antioxidative attributes of the extracts were highly correlated. The impact of supercritical carbon dioxide density on the amount of recovered compounds was confirmed. The use of supercritical CO 2 led to a significant reduction in the volume of organic solvent required for extraction.

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“…The activity of xanthine oxidase (XO) with xanthine as the substrate was measured spectrophotometrically by using the procedure of (Marcocci et al 1994). To prepare xanthine solution (150 mM), xanthine was dissolved in phosphate buffer solution (PBS) and adjusted the pH to 7.5.…”

Section: Xanthine Oxidase Assaymentioning

confidence: 99%

Identification of phenolic compounds in polyphenols-rich extract of Malaysian cocoa powder using the HPLC-UV-ESI—MS/MS and probing their antioxidant properties

et al. 2013

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The antioxidant components of cocoa powder, which is rich in polyphenols, were isolated using column chromatography and high performance liquid chromatography. Polyphenolic compounds were then characterized by high-performance liquid chromatography/Ultraviolet and electronspray ionization-tandem mass spectrometry (HPLC-UV-/ESI-MS-MS). As a result, five phenolic compounds were detected. In this study we also investigated scavenging or the total antioxidant capacity (%) of cocoa polyphenol (CP) fractionated from cocoa powder extract. 114.0 mg/g of gallic acid -equivalent phenolics and 94.3 mg/ g catechin-equivalent flavonoids were quantified in this extract. Their free radical-scavenging activity was assessed by 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH) assay, β-carotene bleaching test, and xanthine oxidase inhibitory activity (OX). Total antioxidant capacity (TAC) was further assessed against the myoglobin-induced oxidation of 6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid (ABTS) and expressed as Trolox equivalent. A high correlation between TAC and phenolic contents indicated that phenolic compounds from cocoa were a major contributor of antioxidant activity (0.967≤r≤1.00). CP extract had significantly (P <0.05) potential antioxidant activities with various concentrations. These results suggest that Polyphenols-rich cocoa extract possess prominent medical properties and can be exploited as natural drug to treat free radical associated diseases.

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The Nitric Oxide-Scavenging Properties of Ginkgo Biloba Extract EGb 761

Cited by 901 publications

References 0 publications

In Vitro Antioxidant and Free Radical Scavenging Activity of Nardostachys jatamansi DC.

In Vitro Antioxidant and Free Radical Scavenging Activity of Nardostachys jatamansi DC.

The Application of Supercritical Carbon Dioxide and Ethanol for the Extraction of Phenolic Compounds from Chokeberry Pomace

Identification of phenolic compounds in polyphenols-rich extract of Malaysian cocoa powder using the HPLC-UV-ESI—MS/MS and probing their antioxidant properties

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