The nitrergic neurotransmission contributes to the anxiolytic‐like effect of <scp><i>Citrus sinensis</i></scp> essential oil in animal models

Hocayen, Palloma de Almeida Soares; Wendler, Etiele; Vecchia, Débora Dalla; Kanazawa, Luiz Kae Sales; Issy, Ana Carolina; Bel, Elaine Del; Andreatini, Roberto

doi:10.1002/ptr.6281

Cited by 9 publications

(3 citation statements)

References 43 publications

(76 reference statements)

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“…In another study with Swiss male mice tests, the essential oil of C. sinensis exerted an anxiolytic-like effect without altering locomotor activity. The researchers found that pre-treatment with Larginine prevented this anxiolytic-like effect in animals and concluded that nitrergic neurotransmission plays a relevant role in the anxiolytic effect of C. sinensis essential oil (Hocayen et al, 2019). A clinical trial tested the effects of orange essential oil compared to fluoxetine in 150 individuals with major depressive disorder -evaluated using the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).…”

Section: Sweet Orange (Citrus Sinensis)mentioning

confidence: 99%

Psychological and neurophysiological effects of inhaled aromatherapy

Passos

Esmaile

Silva

et al. 2022

RSD

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Primary Study Objective: the aim of this review was to filter current research written in English from 2010 to 2020 to elucidate the following question: what are the psychological and neurophysiological effects of inhaled aromatherapy on human health? Papers were selected based on PRISMA recommendations from Pubmed, Science Direct and Virtual Health Library databases. PICO technique and PROSPERO registration were also considered during the elaboration of this Systematic Review. Setting: schools, hospitals, clinics and dental offices. Participants: children, adults and elderly. Intervention: Essential oil inhalation. Primary Outcome Measures: Psychological approaches (eg. psychometric scales and cognitive tasks) and neurophysiological approaches (eg. heart rate variability/HRV and salivary cortisol). Results: From 1.458 papers, 14 were selected for final analysis and displayed in a table containing the following information: Score based on credibility criteria, authors, country, group, sex, age, objective, procedure and outcome. Conclusion: Aromatherapy mainly modulates the autonomic nervous system, with a predominance of parasympathetic activation and contributes to reduce cortisol and to increase melatonin levels. In addition, it can alleviate anxiety, depression and insomnia.

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Section: Sweet Orange (Citrus Sinensis)mentioning

confidence: 99%

Psychological and neurophysiological effects of inhaled aromatherapy

Passos

Esmaile

Silva

et al. 2022

RSD

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“…Due to the growing problem of drug resistance, new therapeutic solutions are sought for, especially those of natural origin. Essential oils, due to their anti-bacterial, anti-fungal, antiinflammatory and immunostimulatory properties, constitute interesting research material in the fight against mould [14][15][16][17][18].…”

Section: Introduction and Objectivementioning

confidence: 99%

Additivity interactions between fluconazole and citrus essential oils to<i> Aspergillus fumigatus</i>

Wróblewska-Łuczka¹,

Łuszczki²

2021

J Pre Clin Clin Res.

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Introduction. Aspergillus fumigatus is the most common pathogen causing allergic bronchopulmonary mycosis. The pathogenic capacity of Aspergillus fumigatus is related to its thermal tolerance and the small size of the spores which enables transfer to the respiratory tract. In the case of fungal diseases, their treatment is based on fungicidal antibiotics, such as fluconazole. Due to the growing problem of drug resistance, new therapeutic solutions are sought, especially of natural origin. Essential oils, due to their anti-bacterial, anti-fungal, anti-inflammatory and immunostimulatory properties, constitute interesting research material in the fight against mould. Objective. The aim of the study was to assess the type of pharmacodynamic interactions between fluconazole and selected essential oils: lemon, orange, tangerine, and grapefruit in an in vitro study against Aspergillus fumigatus. Isobolographic analysis of the results allowed determining the type of interactions between fluconazole and the tested essential oils. Results. According to the research results, a IC 50 dose of fluconazole versus Aspergillus fumigatus IC 50 = 1.87±0.88 mg/ml. The most active essential oil was lemon oil, which at the concentration of 4% in medium completely inhibited the growth of Aspergillus fumigatus. Tangerine essential oil is the least active against A. fumigatus. Isobolographic analysis of the interactions between fluconazole and essential oils showed additive interactions for the combination of fluconazole with lemon, orange and grapefruit ols, and an additive interaction with a tendency to synergism for the combination of fluconazole with tangerine oil. Conclusions. Isobographic analysis can contribute to the introduction of natural substances into the therapy of many diseases.

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“…Sweet orange (Orange peel) and Agarwood are classic Herb pairs, which have the effect of relieving qi stagnancy in liver and resolving stagnation for tranquilization. From the perspective of Western medicine, Lavender [25, 26] has sedative-hypnotic effects and anti-anxiety effects, Sandalwood [27] and Agarwood [28] have sedative-hypnotic effects, Sweet orange [29], Rose [30], Frankincense [31] and Orange Blossom all have anti-depression effects. In this study, the Lavender essential oil, a commonly used in the treatment of insomnia, was combined with the Qi-regulating drugs’ essential oil to prepare the Compound Anshen essential oil and its effect on sedative and hypnotic effects with inhalation administration were studied.…”

Section: Introductionmentioning

confidence: 99%

Sedative and hypnotic effects of compound Anshen essential oil inhalation for insomnia

Zheng

et al. 2019

BMC Complement Altern Med

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BackgroundsThe chemical composition of many essential oils indicates that they have sedative and hypnotic effects, but there is still a lack of systematic studies on the sedative and hypnotic effects of essential oils. In addition, aromatherapy does not seem to have the side effects of many traditional psychotropic substances, which is clearly worthwhile for further clinical and scientific research. The clinical application of essential oils in aromatherapy has received increasing attention, and detailed studies on the pharmacological activities of inhaled essential oils are increasingly needed.Hypothesis/purposeAs insomniacs are usually accompanied by symptoms of depression and anxiety of varying degrees, based on the theory of aromatherapy of Traditional Chinese Medicine, this experiment is to study a Compound Anshen essential oil that is compatible with Lavender essential oil, Sweet Orange essential oil, Sandalwood essential oil and other aromatic medicine essential oils with sedative and hypnotic effects, anti-anxiety and anti-depression effects. To study the sedative and hypnotic effects of Compound Anshen essential oil inhaled and the main chemical components of Compound Anshen essential oil, and to compare and analyze the pharmacodynamics of diazepam, a commonly used drug for insomnia.MethodsThe Open field test and Pentobarbital-induced sleep latency and sleep time experiments were used to analyze and compare the sedative and hypnotic effects of inhaling Compound Anshen essential oil and the administration of diazepam on mice. The changes of 5-HT and GABA in mouse brain were analyzed by Elisa. The main volatile constituents of Compound Anshen essential oil were analyzed by gas chromatography-mass spectrometry (GC-MS).ResultsInhalation of Compound Anshen essential oil can significantly reduce the spontaneous activity of mice, reduce latency of sleeping time and prolong duration of sleeping time. The results of enzyme-linked immunosorbent assay showed that Compound Anshen essential oil can increase the content of 5-HT and GABA in mouse brain. The main volatile chemical constituents of the Compound Anshen essential oil are D-limonene (24.07%), Linalool (21.98%), Linalyl acetate (15.37%), α-Pinene (5.39%), and α-Santalol (4.8%).ConclusionThe study found that the inhalation of Compound Anshen essential oil has sedative and hypnotic effect. This study provides a theoretical basis for further research and development of the sedative and hypnotic effects of Compound Anshen essential oil based on the theory of aromatherapy.

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The nitrergic neurotransmission contributes to the anxiolytic‐like effect of Citrus sinensis essential oil in animal models

Cited by 9 publications

References 43 publications

Psychological and neurophysiological effects of inhaled aromatherapy

Psychological and neurophysiological effects of inhaled aromatherapy

Additivity interactions between fluconazole and citrus essential oils to<i> Aspergillus fumigatus</i>

Sedative and hypnotic effects of compound Anshen essential oil inhalation for insomnia

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