The next generation of biomaterial development

Narayan, Roger J.

doi:10.1098/rsta.2010.0001

Cited by 57 publications

(29 citation statements)

References 37 publications

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“…26 Bone consists of ~70 weight (wt)% CAP, the inorganic mineral phase of bone which is about 20-40 nm in length and is uniquely patterned within the collagen network. [27][28][29] Considering the geometric factors of collagen and CAP, bone cell may be used in a nanoscale environment rather than microscale. Thus, proper nanoscale surface modification methods on metallic implants are highly desired to achieve better and more rapid bonding to bone.…”

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confidence: 99%

Nanotubular surface modification of metallic implants via electrochemical anodization technique

Wang¹,

Jin²,

Zheng³

et al. 2014

IJN

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Due to increased awareness and interest in the biomedical implant field as a result of an aging population, research in the field of implantable devices has grown rapidly in the last few decades. Among the biomedical implants, metallic implant materials have been widely used to replace disordered bony tissues in orthopedic and orthodontic surgeries. The clinical success of implants is closely related to their early osseointegration (ie, the direct structural and functional connection between living bone and the surface of a load-bearing artificial implant), which relies heavily on the surface condition of the implant. Electrochemical techniques for modifying biomedical implants are relatively simple, cost-effective, and appropriate for implants with complex shapes. Recently, metal oxide nanotubular arrays via electrochemical anodization have become an attractive technique to build up on metallic implants to enhance the biocompatibility and bioactivity. This article will thoroughly review the relevance of electrochemical anodization techniques for the modification of metallic implant surfaces in nanoscale, and cover the electrochemical anodization techniques used in the development of the types of nanotubular/nanoporous modification achievable via electrochemical approaches, which hold tremendous potential for bio-implant applications. In vitro and in vivo studies using metallic oxide nanotubes are also presented, revealing the potential of nanotubes in biomedical applications. Finally, an outlook of future growth of research in metallic oxide nanotubular arrays is provided. This article will therefore provide researchers with an in-depth understanding of electrochemical anodization modification and provide guidance regarding the design and tuning of new materials to achieve a desired performance and reliable biocompatibility.

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confidence: 99%

Nanotubular surface modification of metallic implants via electrochemical anodization technique

Wang¹,

Jin²,

Zheng³

et al. 2014

IJN

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“…Biodegradable polymers established in clinical applications have controlled degradation rate [64,65], avoid the production of byproducts [64], and preserve mechanical and chemical properties [66,67]. Materials meeting these requirements and used for periodontal or tooth regeneration [68,69] are classified as hydrolytically and enzymatically degradable [70][71][72][73]. …”

Section: Dental Regenerative Therapymentioning

confidence: 99%

Biodegradable polymers for dental tissue engineering and regeneration

Conte¹,

Riccitiello²,

Luise³

et al. 2017

Biodegradable Polymers: Recent Developments and New Perspectives

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“…The evolution in the concept from substitution to repair has recently been replaced by the idea of regeneration [1,[9][10][11][12]. This idea can be illustrated by focusing on third-generation bioceramics, where the aim is to provide appropriate scaffolding for cells, allowing them to perform their bone regeneration work.…”

Section: Introductionmentioning

confidence: 99%

Structure and functionalization of mesoporous bioceramics for bone tissue regeneration and local drug delivery

Vallet‐Regí

Izquierdo‐Barba

Colilla

2012

Phil. Trans. R. Soc. A.

160

139

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This review article describes the importance of structure and functionalization in the performance of mesoporous silica bioceramics for bone tissue regeneration and local drug delivery purposes. Herein, we summarize the pivotal features of mesoporous bioactive glasses, also known as 'templated glasses' (TGs), which present chemical compositions similar to those of conventional bioactive sol-gel glasses and the added value of an ordered mesopore arrangement. An in-depth study concerning the possibility of tailoring the structural and textural characteristics of TGs at the nanometric scale and their influence on bioactive behaviour is discussed. The highly ordered mesoporous arrangement of cavities allows these materials to confine drugs to be subsequently released, acting as drug delivery devices. The functionalization of mesoporous silica walls has been revealed as the cornerstone in the performance of these materials as controlled release systems. The synergy between the improved bioactive behaviour and local sustained drug release capability of mesostructured materials makes them suitable to manufacture threedimensional macroporous scaffolds for bone tissue engineering. Finally, this review tackles the possibility of covalently grafting different osteoinductive agents to the scaffold surface that act as attracting signals for bone cells to promote the bone regeneration process.

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The next generation of biomaterial development

Cited by 57 publications

References 37 publications

Nanotubular surface modification of metallic implants via electrochemical anodization technique

Nanotubular surface modification of metallic implants via electrochemical anodization technique

Biodegradable polymers for dental tissue engineering and regeneration

Structure and functionalization of mesoporous bioceramics for bone tissue regeneration and local drug delivery

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