The New Frontier of Nutrition Science

Peregrin, Tony

doi:10.1016/s0002-8223(01)00309-1

Cited by 49 publications

(27 citation statements)

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“…Nutrigenomics is the convergence of three areas of researchhealth, diet, and genomics -and has been reviewed by numerous researchers (Bauer et al, 2004;Chadwick, 2004;Fenech, 2005;Gillies, 2003;Junien and Gallou, 2004;Kaput and Rodriguez, 2004;Muller and Kersten, 2003;Ommen and Groten, 2004;Ordovas and Mooser, 2004;Peregrin, 2001;Ruden et al, 2005;Trayhurn, 2003;van Ommen, 2004;van Ommen and Stierum, 2002). Health and diet converge in the field of nutrition, diet and genomics converge in the emerging fields of expression profiling, proteomics, and metabolomics, whereas health and genomics converge in the field of identifying biomarkers to classify and understand diseases .…”

Section: Nutrigenomics Approaches Nutrigenomics Approaches Nutrigenommentioning

confidence: 99%

Evolutionary conservation of metabolism explains howDrosophila nutrigenomics can help us understand human nutrigenomics

Ruden

2006

Genes Nutr

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Section: Nutrigenomics Approaches Nutrigenomics Approaches Nutrigenommentioning

confidence: 99%

Evolutionary conservation of metabolism explains howDrosophila nutrigenomics can help us understand human nutrigenomics

Ruden

2006

Genes Nutr

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“…Similar to the practice in the related fields of pharmacogenomics and pharmacogenetics (Lindpaintner, 2002), the terms nutrigenomics and nutrigenetics are largely used interchangeably. However, there are important conceptual differences in their approaches and aims (Peregrin, 2001;van Ommen & Stierum, 2002;Muller & Kersten, 2003;Trayhurn, 2003). Nutrigenomics applies to the comprehensive genomewide assessment of the effects of dietary factors or interventions.…”

Section: Bringing All Together: Nutrigenomics and Nutrigeneticsmentioning

confidence: 99%

The quest for cardiovascular health in the genomic era: nutrigenetics and plasma lipoproteins

Ordovas

2004

Proc. Nutr. Soc.

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Nutrigenetics and nutrigenomics are promising multidisciplinary fields that focus on studying the interactions between nutritional factors, genetic factors and health outcomes. Their goal is to achieve more efficient individual dietary intervention strategies aimed at preventing disease, improving quality of life and achieving healthy aging. Our studies, and those of many other investigators, using population-based and intervention studies have found evidence for interactions between dietary factors, genetic variants and biochemical markers of CVD. Now, the characterization of individuals who may respond better to one type of dietary recommendation than another can be begun. Thus, a low-fat low-cholesterol strategy may be particularly efficacious in lowering the plasma cholesterol levels of those subjects carrying the apoE4 allele at the APOE gene. HDL-cholesterol (HDL-C) levels are also modulated by dietary, behavioural and genetic factors. It has been reported that the effect of PUFA intake on HDL-C concentrations is modulated by an APOA1 genetic polymorphism. Thus, subjects carrying the A allele at the -75 G/A polymorphism show an increase in HDL-C with increased intakes of PUFA, whereas those homozygotes for the more common G allele have the expected lowering of HDL-C levels with increased intake of PUFA. Variability at the hepatic lipase gene is also associated with interactions between intake of fat and HDL-C concentrations that could shed some light on the different abilities of certain ethnic groups to adapt to new nutritional environments. This knowledge should lead to successful dietary recommendations partly based on genetic factors that may help to reduce cardiovascular risk more efficiently than the current universal recommendations.

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“…The first PubMed entry of a paper using the word nutrigenomics in its title was observed in 2001 (Peregrin, 2001), and in the last six years, 71 other papers have already been published about this topic, showing its particular relevance to the present scenario of genomic studies. Although it has always been clear that a large number of dietary chemicals alter the regulation of biological processes and, either directly or indirectly, the expression of genetic information, researchers are just now beginning to take this influence into account and trying to measure it precisely (Kaput et al, 2007;Fenech, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Although it has always been clear that a large number of dietary chemicals alter the regulation of biological processes and, either directly or indirectly, the expression of genetic information, researchers are just now beginning to take this influence into account and trying to measure it precisely (Kaput et al, 2007;Fenech, 2008). Most of these dozens of papers in the nutrigenomics field are still theoretical, proposing possible experimental strategies and future perspectives to study interactions between genomics and nutrition (Peregrin, 2001;van Ommen and Stierum, 2002;Chavez and Munoz, 2003;Muller and Kersten, 2003;Trayhurn, 2003;Chadwick, 2004). Researchers agree that nutrigenomics shall be considered the study of both the genetic factors influencing organisms' response to diet (Low and Tai, 2007) and the effects of food on the host genome and gene expression (Ozdemir and Godard, 2007;Roy et al, 2007;Ye et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Essential amino acid usage and evolutionary nutrigenomics of eukaryotes - insights into the differential usage of amino acids in protein domains and extra-domains

2008

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ABSTRACT. Nutrigenomics studies the effects of nutrients on the genome, transcriptome and proteome of organisms, and here an evolutionary standpoint on this new discipline is presented. It is well known that metazoan organisms are unable to synthesize all amino acids necessary to produce their proteins and that these essential amino acids (EAA) must be acquired from the diet. Here, we tested the hypothesis that conserved regions such as protein domains (DM) have different essentiality indexes and use different sets of amino acids when compared to extra-domains (ED) and proteins without mapped domains (WD). We found that auxotrophic organisms have a tendency to use less EAAs in DM than do prototrophic ones. Looking into the amino acid usage of eukaryotic proteins downloaded from KEGG and COG, we showed that WD have a usage of amino acids closer to DM, which suggests that proteins without mapped domains behave as large domains. Using an ED index that shows the proportion of prevalent amino acids in ED, a differential usage of amino acids in domains versus extra-domains was demonstrated. Protein domains were shown to be enriched with a higher number of EAA, and it may be related to the fact that these amino acids had lost their biosynthetic pathways in metazo- ans during a great amino acid pathway deletion, followed by a nutritional constraint that may have happened close to the conquest of the terrestrial environment. Thus, the proportion of EAA outside domains could have decreased during evolution due to nutritional constraints.

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The New Frontier of Nutrition Science

Cited by 49 publications

References 0 publications

Evolutionary conservation of metabolism explains howDrosophila nutrigenomics can help us understand human nutrigenomics

Evolutionary conservation of metabolism explains howDrosophila nutrigenomics can help us understand human nutrigenomics

The quest for cardiovascular health in the genomic era: nutrigenetics and plasma lipoproteins

Essential amino acid usage and evolutionary nutrigenomics of eukaryotes - insights into the differential usage of amino acids in protein domains and extra-domains

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