Evolutionary conservation of metabolism explains howDrosophila nutrigenomics can help us understand human nutrigenomics

Ruden, Douglas M.; Lu, Xiangyi

doi:10.1007/bf02829949

Cited by 12 publications

(8 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, it possesses defined organs including gut, brain and fat body. Drosophila melanogaster holds a complex and dynamic gut exhibiting a similar structure and organization like the mammalian gut predestining it as a feasible model organism in nutrition research [ 32 – 35 ]. The application of the EGCG-rich green tea extract significantly extended lifespan in male flies.…”

Section: Discussionmentioning

confidence: 99%

Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster

et al. 2015

View full text Add to dashboard Cite

In this study, we tested whether a standardized epigallocatechin-3-gallate (EGCG) rich green tea extract (comprising > 90% EGCG) affects fitness and lifespan as well as parameters of glucose metabolism and energy homeostasis in the fruit fly, Drosophila melanogaster. Following the application of the green tea extract a significant increase in the mean lifespan (+ 3.3 days) and the 50% survival (+ 4.3 days) as well as improved fitness was detected. These effects went along an increased expression of Spargel, the homolog of mammalian PGC1α, which has been reported to affect lifespan in flies. Intriguingly, in flies, treatment with the green tea extract decreased glucose concentrations, which were accompanied by an inhibition of α-amylase and α-glucosidase activity. Computational docking analysis proved the potential of EGCG to dock into the substrate binding pocket of α-amylase and to a greater extent into α-glucosidase. Furthermore, we demonstrate that EGCG downregulates insulin-like peptide 5 and phosphoenolpyruvate carboxykinase, major regulators of glucose metabolism, as well as the Drosophila homolog of leptin, unpaired 2. We propose that a decrease in glucose metabolism in connection with an upregulated expression of Spargel contribute to the better fitness and the extended lifespan in EGCG-treated flies.

show abstract

Section: Discussionmentioning

confidence: 99%

Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The genome similarity and presence of highly conserved metabolic pathways with eukaryotes including human make Drosophila one of the best model organisms for investigating various genetic and metabolic pathways to avail the ground level understanding on various gene-environment interactions and their relation to aging process [24, 25]. …”

Section: Introductionmentioning

confidence: 99%

Dietary Intake ofCurcuma longaandEmblica officinalisIncreases Life Span inDrosophila melanogaster

Rawal

Singh

Gupta

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

Intake of food and nutrition plays a major role in affecting aging process and longevity. However, the precise mechanisms underlying the ageing process are still unclear. To this respect, diet has been considered to be a determinant of ageing process. In order to better illustrate this, we used Drosophila melanogaster as a model and fed them orally with different concentrations of two commonly used Indian medicinal plant products, Curcuma longa (rhizome) and Emblica officinalis (fruit). The results revealed significant increase in life span of Drosophila flies on exposure to both the plant products, more efficiently by C. Longa than by E. officinalis. In order to understand whether the increase in lifespan was due to high-antioxidant properties of these medicinal plants, we performed enzymatic assays to assess the SOD and catalase activities in case of both treated and control Drosophila flies. Interestingly, the results support the free radical theory of aging as both these plant derivatives show high reactive oxygen species (ROS) scavenging activities.

show abstract

“…So far, nutrigenomic studies on D. melanogaster have been used to further our understanding of human nutrigenomics, as metabolism is evolutionarily conserved (Ruden & Lu, 2006), and a promising way of developing strategies for dealing with metabolic diseases (Matzkin et al, 2011).…”

mentioning

confidence: 99%

Fitness traits of Drosophila melanogaster (Diptera: Drosophilidae) after long-term laboratory rearing on different diets

Trajković¹,

Vujić²,

Miličić³

et al. 2017

Eur. J. Entomol.

View full text Add to dashboard Cite

Abstract. Nutrition is one of the most important environmental factors that infl uence the development and growth in Drosophila. The food composition strongly affects their reproduction, welfare and survival, so it is necessary for fl ies to search for a mixture of macronutrients that maximizes their fi tness. We have fi ve D. melanogaster strains, which were reared for 13 years on fi ve different substrates: standard cornmeal-agar-sugar-yeast medium and four substrates modifi ed by adding tomato, banana, carrot and apple. This study was aimed at determining how such long-term rearing of fl ies on substrates with different protein content affects fi tness traits (dynamics of eclosion, developmental time and egg-to-adult survival). Further, we determined how transferring fl ies reared on fruit/vegetable substrates to a standard laboratory diet affected their fi tness. Results indicate that strains reared on the diet with the lowest content of protein and the highest C/N ratio had the slowest eclosion and developmental time, and lowest egg-to-adult survival (apple diet). The fl ies reared on the diet with the highest protein content and the lowest C/N ratio had the highest survival (tomato diet). Flies reared on the carrot diet, which is quite similar in protein content and C/N ratio to the standard cornmeal diet, had the fastest development. Transferring fl ies to the standard cornmeal diet accelerate eclosion and developmental time, but did not affect survival.

show abstract

Evolutionary conservation of metabolism explains howDrosophila nutrigenomics can help us understand human nutrigenomics

Cited by 12 publications

References 72 publications

Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster

Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster

Dietary Intake ofCurcuma longaandEmblica officinalisIncreases Life Span inDrosophila melanogaster

Fitness traits of Drosophila melanogaster (Diptera: Drosophilidae) after long-term laboratory rearing on different diets

Contact Info

Product

Resources

About